Research Group on Nuclear Receptors in Cardiometabolic Pathology

Metabolism and Organic Damage Area

Identification of new mechanisms involved in angiogenesis and inflammation in obese patients

– Study and characterization of the role of the CCR4 receptor and its ligands CCL17 / TARCE, CCL22 / MDC and CKLF1 in angiogenesis and inflammation associated with obesity and in response to bariatric surgery

– Characterization of the role of constitutive nuclear receptors for androstane (CAR) in endothelial dysfunction and angiogenesis associated with obesity and in response to bariatric surgery

Identification of new mechanisms involved in angiogenesis and inflammation in acute myocardial infarction. Role of the anti-angiogenic isoform VEGF165b

– Determination of VEGF-A165b levels in patients with STEMI and its relationship with microvascular obstruction

– To study the effects of neutralization of the VEGF-165b isoform in a mouse model with acute infarction

Study of the role of the SGLT2 transporter in the development of abdominal aortic aneurysm

– To evaluate the effect of empagliflozin, an inhibitor of SGLT2, in an animal model of abdominal aortic aneurysm and to investigate the possible anti-inflammatory effect of empagliflozin in dysfunction endothelial

Coordinatora
Dra. Laura Piqueras Ruiz
laura.piqueras@uv.es

RESEARCHERS
Leading, R4
Established, R3

Laura Piqueras Ruiz    

Recognised/Emerging, R2
First Stage, R1
STAFF
Collaborating Researchers

Julia Ferrol Navarro
Mª del Mar García Guerrero

Nurse
Technicians

Ángela Vea Badenes

Administrative assistant
Publications
Targeting systemic inflammation in metabolic disorders. A therapeutic candidate for the prevention of cardiovascular diseases?. Domingo E, Marques P, Francisco V, Piqueras L, Sanz M. Pharmacological Research. 2024 Jan 11:S0214-9168(23)00120-1. doi: 10.1016/j.arteri.2023.12.005. PMID: 38218355

Anti-inflammatory effects and improved metabolic derangements in ob/ob mice by a newly synthesized prenylated benzopyran with pan-PPAR activity. Marques P, Villarroel-Vicente C, Collado A, Garcia A, Vila L, Duplan I, Hennuyer N, Garibotto F, Enriz RD, Dacquet C, Staels B, Piqueras L, Cortes D, Sanz MJ, Cabedo N. Pharmacological Research. 2023 Jan;187:106638. doi: 10.1016/j.phrs.2022.106638. PMID: 36586645

CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction. Hueso L, Marques P, Morant B, Gonzalez-Navarro H, Ortega J, Real J, Sanz M, Piqueras L. Frontiers in Endocrinology. 2023 Apr 12;14:1154158. doi: 10.3389/fendo.2023.1154158. PMID: 37124725

Overview of cellular and soluble mediators in systemic inflammation associated with non-alcoholic fatty liver disease. Marques P, Francisco V, Martinez-Arenas L, Carvalho-Gomes A, Domingo E, Piqueras L, Berenguer M, Sanz M. International Journal of Molecular Sciences. 2023 Jan 24;24(3):2313. doi: 10.3390/ijms24032313. PMID: 36768637

Association of chemokines IP-10/CXCL10 and I-TAC/CXCL11 with insulin resistance and enhance leukocyte endothelial arrest in obesity. Moreno B, Hueso L, Ortega R, Benito E, Martinez Hervas S, Peiro M, Civera M, Sanz MJ, Piqueras L, Real JT. Microvascular Research. 2022 Jan;139:104254. doi: 10.1016/j.mvr.2021.104254. PMID: 34534571

Beneficial effects of PCSK9 inhibition with alirocumab in familial hypercholesterolemia involve modulation of new immune players. Marques P, Domingo E, Rubio A, Martinez-Hervas S, Ascaso JF, Piqueras L, Real JT, Sanz MJ. Biomedicine & Pharmacotherapy. 2022 Jan;145:112460. doi: 10.1016/j.biopha.2021.112460. PMID: 34864314

Activation of the constitutive androstane receptor inhibits leukocyte adhesiveness to dysfunctional endothelium. Lopez-Riera M, Ortega R, Hueso L, Montesinos MC, Gomez-Cabrera MC, Sanz MJ, Real JT, Piqueras L. International Journal of Molecular Sciences. 2021 Aug 27;22(17):9267. doi: 10.3390/ijms22179267. PMID: 34502180

An updated overview of e-cigarette impact on human health. Marques P, Piqueras L, Sanz MJ. Respiratory Research. 2021 May 18;22(1):151. doi: 10.1186/s12931-021-01737-5. PMID: 34006276

Dissecting abdominal aortic aneurysm is aggravated by genetic inactivation of LIGHT (TNFSF14). Herrero-Cervera A, Espinos-Estevez C, Martin-Vano S, Taberner-Cortes A, Aguilar-Ballester M, Vinue A, Piqueras L, Martinez-Hervas S, Gonzalez-Navarro H. Biomedicines. 2021 Oct 22;9(11):1518. doi: 10.3390/biomedicines9111518. PMID: 34829747

Oral unsaturated fat load impairs postprandial systemic inflammation in primary hypercholesterolemia patients. Collado A, Domingo E, Marques P, Perello E, Martínez-Hervás S, Piqueras L, Ascaso JF, Real JT, Sanz MJ. Frontiers in Pharmacology. 2021 Apr 20;12:656244. doi: 10.3389/fphar.2021.656244. PMID: 33959024

Peripheral blood levels of CXCL10 are a useful marker for diabetic polyneuropathy in subjects with type 2 diabetes. Ascaso P, Palanca A, Martinez-Hervas S, Sanz MJ, Ascaso JF, Piqueras L, Real JT. International Journal of Clinical Practice. 2021 Aug;75(8):e14302. doi: 10.1111/ijcp.14302. PMID: 33930221

Postprandial triglyceridemia is modulated by insulin resistance but not by grade of obesity in abdominal and morbid obese subjects. Moreno-Perez B, Benito E, Civera M, Alabadi B, Martinez-Hervas S, Peiro M, Gonzalez-Navarro H, Piqueras L, Jesus Sanz M, Ascaso J, Real J. International Journal of Clinical Practice. 2021 Apr;75(4):e13776. doi: 10.1111/ijcp.13776. PMID: 33089594

Primary hypercholesterolemia and development of cardiovascular disorders: Cellular and molecular mechanisms involved in low-grade systemic inflammation and endothelial dysfunction. Collado A, Domingo E, Piqueras L, Sanz MJ. International Journal of Biochemistry & Cell Biology. 2021 Oct;139:106066. doi: 10.1016/j.biocel.2021.106066. PMID: 34438057

Role of antiangiogenic VEGF-A165b in angiogenesis and systolic function after reperfused myocardial infarction. Rios Navarro C, Hueso Soler L, Diaz Cuevas A, Marcos Garcés V, Bonanad Lozano C, Ruiz Sauri A, Vila Salinas J, Sanz Ferrando M, Chorro Gascó F, Piqueras Ruiz L, Bodí Peris V. Revista espanola de Cardiologia (English ed.). 2021 Feb;74(2):131-139. doi: 10.1016/j.rec.2020.03.013. PMID: 32474003

The nuclear retinoid-related orphan receptor RORalpha controls adipose tissue inflammation in patients with morbid obesity and diabetes. Ortega R, Hueso L, Benito E, Ortega J, Civera M, Sanz M, Real J, Piqueras L. International Journal of Obesity. 2021 Jul;45(7):1369-1381. doi: 10.1038/s41366-021-00787-5. PMID: 33637954

Projects
Reference: PI21/00220
Title: Estudio de nuevos ejes de quimiocinas como potenciales dianas de intervención en la obesidad y la resistencia a la insulina
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Laura Piqueras Ruiz, José Tomas Real Collado
Duration: 2022 – 2024
Total budget: 204.490 €
Reference: CDEI0420A
Title: Plan GenT
Funding body: Conselleria de Sanidad
Principal Investigator: Laura Piqueras Ruiz
Duration: 2020 – 2023
Total budget: 253500
Reference: PI18/00209
Title: Identificación de nuevos mecanismos implicados en la angiogénesis e inflamación en pacientes obesos. Modulación por ligandos de receptores nucleares constitutivos de androstano
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Laura Piqueras Ruiz, José Tomas Real Collado
Duration: 2019 – 2022
Total budget: 173.333 €
Reference: AICO/2019/250
Title: Efecto de la cirugía bariátrica en la inflamación vascular en pacientes con obesidad mórbida y diabéticos
Funding body: Conselleria de Educación
Principal Investigator: Laura Piqueras Ruiz
Duration: 2019 – 2020
Total budget: 40000
Reference: PIE15/00013
Title: A multidisciplinary Project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Vicente Bodí Peris
Duration: 2016 – 2019
Total budget: 589.050 €
+ Info
Title: Estudio de nuevos mecanismos angiogénicos e inflamatorios asociados a la obesidad
Doctoral candidate: Hueso Soler, Luisa María
Director(s): Piqueras Ruiz, Laura; Real Collado, Jose Tomás; Sanz Ferrando, María Jesús
Date of the defense: 28/04/2023
University: Universitat de València

Title: Effect of SGLT-2 inhibition in abdominal aortic aneurysm development. Role of rora in adipose tissue inflammation associated to obesity
Doctoral candidate: Ortega Herráiz, Rebeca
Director(s): Piqueras Ruiz, Laura; Sanz Ferrando, María Jesús; Real Collado, José Tomás
Date of the defense: 21/02/2022
University: Universitat de València

Title: Chemokine axes and inflammatory status in metabolic syndrome. Effect of pcsk9 inhibitors in the systemic inflammation associated to familial hypercholesterolemia
Doctoral candidate: Gomes Marques, Patrice
Director(s): Piqueras Ruiz, Laura; Sanz Ferrando, María Jesús
Date of the defense: 07/02/2020
University: Universitat de València

Title: Study of the systemic inflammation associated to primary hypercholesterolemia, its modulation and its impact in atherosclerosis. Role of cxcl16/cxcr6 axis in abdominal aortic aneurysm formation
Doctoral candidate: Collado Sánchez, Aida
Director(s): Sanz Ferrando, María Jesús; Piqueras Ruiz, Laura
Date of the defense: 22/07/2019
University: Universitat de València