Dr. Consuelo Borrás Blasco

Principal Investigator
Research Group on Healthy Aging (MiniAging)

Presentation

Principal
Investigator
Dr. Consuelo Borrás Blasco

consuelo.borras@uv.es

Publications
Altered lipid moieties and carbonyls in a wistar rat dietary model of subclinical fatty liver: potential sex-specific biomarkers of early fatty liver disease?. Martín-Grau M, Pardo-Tendero M, Casanova P, Dromant M, Marrachelli V, Morales J, Borrás C, Pisoni S, Maestrini S, Di Blasio A, Monleon D. Antioxidants. 2023 Sep 28;12(10):1808. doi: 10.3390/antiox12101808. PMID: 37891887

Assessment and risk prediction of frailty using texture-based muscle ultrasound image analysis and machine learning techniques. Miron-Mombiela R, Ruiz-Espana S, Moratal D, Borras C. Mechanisms of Ageing and Development. 2023 Sep 4;215:111860. doi: 10.1016/j.mad.2023.111860. PMID: 37666473

Extracellular vesicles as therapeutic resources in the clinical environment. Sanz Ros J, Mas Bargues C, Romero Garcia N, Huete Acevedo J, Dromant M, Borras C. International Journal of Molecular Sciences. 2023 Jan 25;24(3):2344. doi: 10.3390/ijms24032344. PMID: 36768664

Extracellular vesicles: the future of diagnosis in solid organ transplantation?. Romero-Garcia N, Huete-Acevedo J, Mas-Bargues C, Sanz-Ros J, Dromant M, Badenes R, Borras C. International Journal of Molecular Sciences. 2023 Mar 7;24(6):5102. doi: 10.3390/ijms24065102. PMID: 36982182

Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome. Sol J, Obis E, Mota Martorell N, Pradas I, Galo Licona J, Martin Gari M, Fernandez Bernal A, Ortega Bravo M, Mayneris Perxachs J, Borras C, Vina J, de la Fuente M, Mate I, Biarnes C, Pedraza S, Vilanova J, Brugada R, Ramos R, Serena J, Ramio-Torrenta L, Pineda V, Daunis I Estadella P, Thio Henestrosa S, Barretina J, Garre Olmo J, Portero Otin M, Fernandez Real J, Puig J, Jove M, Pamplona R. Aging Cell. 2023 Jun;22(6):e13821. doi: 10.1111/acel.13821. PMID: 36951231

Randomised controlled trial combining vitamin E-functionalised chocolate with physical exercise to reduce the risk of protein-energy malnutrition in predementia aged people: study protocol for Choko-Age. Pedrinolla A, Isanejad M, Antognelli C, Bartolini D, Borras C, Cavedon V, Di Sante G, Migni A, Mas-Bargues C, Milanese C, Baschirotto C, Modena R, Pistilli A, Rende M, Schena F, Stabile AM, Telesa NV, Tortorella S, Hemmings K, Vina J, Wang E, McArdle A, Jackson MJ, Venturelli M, Galli F. BMJ Open. 2023 Dec 22;13(12):e072291. doi: 10.1136/bmjopen-2023-072291. PMID: 38135320

Small extracellular vesicles from senescent stem cells trigger adaptive mechanisms in young stem cells by increasing antioxidant enzyme expression. Mas-Bargues C, Sanz-Ros J, Romero-Garcia N, Huete-Acevedo J, Dromant M, Borras C. Redox Biology. 2023 Jun:62:102668. doi: 10.1016/j.redox.2023.102668. PMID: 36965438

The double-edged role of extracellular vesicles in the hallmarks of aging. Romero-Garcia N, Huete-Acevedo J, Mas-Bargues C, Sanz-Ros J, Dromant M, Borras C. Biomolecules. 2023 Jan 13;13(1):165. doi: 10.3390/biom13010165. PMID: 36671550

The potential use of mitochondrial extracellular vesicles as biomarkers or therapeutical tools. Sanz-Ros J, Mas-Bargues C, Romero-Garcia N, Huete-Acevedo J, Dromant M, Borras C. International Journal of Molecular Sciences. 2023 Apr 10;24(8):7005. doi: 10.3390/ijms24087005. PMID: 37108168

The role of extracellular vesicles in aging and disease. Borrás C, Mas-Bargues C. International Journal of Molecular Sciences. 2023 Sep 6;24(18):13739. doi: 10.3390/ijms241813739. PMID: 37762042

Blood DNA methylation patterns in older adults with evolving dementia. Fernandez Perez R, Alba Linares JJ, Tejedor JR, Fernandez Fernandez A, Calero M, Roman Dominguez A, Borras C, Vina J, Avila J, Medina M, Fernandez Fraga M. The journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2022 Sep 1;77(9):1743-1749. doi: 10.1093/gerona/glac068. PMID: 35299244

Functional transcriptomic analysis of centenarians’ offspring reveals a specific genetic footprint that may explain that they are less frail than age-matched non-centenarians’ offspring. Ingles M, Belenguer-Varea A, Serna E, Mas-Bargues C, Tarazona-Santabalbina F, Borras C, Vina J. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2022 Oct 6;77(10):1931-1938. doi: 10.1093/gerona/glac119. PMID: 35640160

Genistein effect on cognition in prodromal Alzheimer’s disease patients. The GENIAL clinical trial. Vina J, Escudero J, Baquero M, Cebrian M, Carbonell-Asins J, Munoz J, Satorres E, Melendez J, Ferrer-Rebolleda J, Cozar-Santiago M, Santabarbara-Gomez J, Jove M, Pamplona R, Tarazona-Santabalbina F, Borras C. Alzheimers Research & Therapy. 2022 Nov 4;14(1):164. doi: 10.1186/s13195-022-01097-2. PMID: 36329553

Genistein, a tool for geroscience. Bargues C, Borras C, Vina J. Mechanisms of Ageing and Development. 2022 Jun;204:111665. doi: 10.1016/j.mad.2022.111665. PMID: 35307412

Long-lived humans have a unique plasma sphingolipidome. Pradas I, Jove M, Huynh K, Ingles M, Borras C, Mota-Martorell N, Galo-Licona JD, Puig J, Vina J, Meikle PJ, Pamplona R. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2022 Apr 1;77(4):728-735. doi: 10.1093/gerona/glab360. PMID: 34871393

Recent approaches to determine static and dynamic redox state-related parameters. Mas-Bargues C, Garcia-Dominguez E, Borras C. Antioxidants. 2022 Apr 28;11(5):864. doi: 10.3390/antiox11050864. PMID: 35624728

Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice. Sanz-Ros J, Romero-Garcia N, Mas-Bargues C, Monleon D, Gordevicius J, Brooke RT, Dromant M, Diaz A, Derevyanko A, Guio-Carrion A, Roman-Dominguez A, Ingles M, Blasco MA, Horvath S, Vina J, Borras C. Science Advances. 2022 Oct 21;8(42):eabq2226. doi: 10.1126/sciadv.abq2226. PMID: 36260670

Special issue “Oxidative stress in aging and associated chronic diseases”. Mas-Bargues C, Alique M, Barrús-Ortiz MT, Borrás C, Rodrigues-Díez R. Antioxidants. 2022 Apr 2;11(4):701. doi: 10.3390/antiox11040701. PMID: 35453386

The contribution of extracellular vesicles from senescent endothelial and vascular smooth muscle cells to vascular calcification. Mas-Bargues C, Borras C, Alique M. Frontiers In Cardiovascular Medicine. 2022 Apr 15;9:854726. doi: 10.3389/fcvm.2022.854726. PMID: 35498012

The multimodal action of genistein in Alzheimer’s and other age-related diseases. Mas-Bargues C, Borras C, Vina J. Free Radical Biology & Medicine. 2022 Apr;183:127-137. doi: 10.1016/j.freeradbiomed.2022.03.021. PMID: 35346775

Therapeutic potential of extracellular vesicles in aging and age-related diseases. Sanz-Ros J, Mas-Bargues C, Romero-Garcia N, Huete-Acevedo J, Dromant M, Borras C. International Journal of Molecular Sciences. 2022 Nov 23;23(23):14632. doi: 10.3390/ijms232314632. PMID: 36498960

What genetics can do for oncological imaging: a systematic review of the genetic validation data used in radiomics studies. Mombiela R, Arildskov A, Bruun F, Hasselbalch L, Holst K, Rasmussen S, Borras C. International Journal of Molecular Sciences. 2022 Jun 10;23(12):6504. doi: 10.3390/ijms23126504. PMID: 35742947

Bcl-xL as a Modulator of Senescence and Aging. Mas-Bargues C, Borras C, Vina J. International Journal of Molecular Sciences. 2021 Feb 3;22(4):1527. doi: 10.3390/ijms22041527. PMID: 33546395

Diagnostic performance of muscle echo intensity and fractal dimension for the detection of frailty phenotype. Miron Mombiela R, Vucetic J, Monllor P, Cardenas-Herran JS, Taltavull de la Paz P, Borras C. Ultrasonic Imaging. 2021 Nov;43(6):337-352. doi: 10.1177/01617346211029656. PMID: 34238072

Estrogen replacement therapy induces antioxidant and longevity-related genes in women after medically induced menopause. Borras C, Ferrando M, Ingles M, Gambini J, Lopez-Grueso R, Edo R, Mas-Bargues C, Pellicer A, Vina J. Oxidative Medicine and Cellular Longevity. 2021 Sep 9;2021:8101615. doi: 10.1155/2021/8101615. PMID: 34539974

Exploring new kingdoms: the role of extracellular vesicles in oxi-inflamm-aging related to cardiorenal syndrome. Mas-Bargues C, Alique M, Barrus-Ortiz M, Borras C, Rodrigues-Diez R. Antioxidants. 2021 Dec 29;11(1):78. doi: 10.3390/antiox11010078. PMID: 35052582

Importance of stem cell culture conditions for their derived extracellular vesicles therapeutic effect. Mas-Bargues C, Borras C. Free Radical Biology & Medicine. 2021 May 20;168:16-24. doi: 10.1016/j.freeradbiomed.2021.03.028. PMID: 33781893

Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus. Borras C, Abdelaziz KM, Diaz A, Gambini J, Jove M, Lopez-Grueso R, Mas-Bargues C, Monleon D, Pamplona R, Vina J. Mechanisms of Ageing and Development. 2021 Dec;200:111596. doi: 10.1016/j.mad.2021.111596. PMID: 34774606

Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease. Mas-Bargues C, Escrivá C, Dromant M, Borrás C, Viña J. Archives of Biochemistry and Biophysics. 2021 Sep 30;709:108941. doi: 10.1016/j.abb.2021.108941. PMID: 34097903

Projects
Reference: CHOKO-AGE AC20/00026
Title: Combining vitamin E-functionalized CHOcolate with physical exercise to reduce the risK of protein energy malnutrition in pre-dementia AGEd people. ERA-HDHL Call for Joint Transnational Research Proposals on Development of targeted nutrition for prevention of undernutrition for older adults (PREVNUT)
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: José Viña Ribes
Duration: 2021 – 2023
Total budget: 169.098 €
Reference: PID2020-113839RB-I00
Title: Efecto del tratamiento con vesículas extracelulares de células madre de grasa de ratones jóvenes sobre parámetros de envejecimiento y fragilidad en ratones de edad avanzada
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Consuelo Borrás Blasco
Duration: 2021 – 2024
Total budget: 181.500 €
Reference: PCIN-2017-117
Title: Obesidad materna y disfunción cognitiva en la descendencia: papel causa-efecto de la microbiota intestinal y prevención dietética temprana
Funding body: Ministerio de Economía y Competitividad
Principal Investigator: Consuelo Borrás Blasco
Duration: 2017 – 2022
Total budget: 143.000 €
Reference: INTIMIC-085
Title: GUTMOM: Maternal obesity and cognitive dysfunction in the offspring: cause-effect role of the GUT MicrobiOMe and early dietary prevention
Funding body: European Commission. JPI HDHL
Principal Investigator: Patricia Lozzo
Duration: 2017 – 2020
Total budget: 778.240 €
Reference: COST Action CA15203 MITOEAGLE
Title: Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
Funding body: European Commission
Principal Investigator: Erich Gnaiger
Duration: 2016 – 2020
Total budget:
+ Info
Title: Muscle architecture determined by ultrasound for the diagnosis of frailty with correlation of clinical, physical and biochemical markers
Doctoral candidate: Vucetic, Jelena
Director(s): Borrás Blasco, Consuelo; Mirón Mombiela, Rebeca; Marcaida Benito, Goizane
Date of the defense: 18/05/2023
University: University de Valencia

Title: Efecto favorable de la comunicación intercelular a través de vesículas extracelulares derivadas de células madre del tejido adiposo en el envejecimiento.
Doctoral candidate: Sanz Ros, Jorge Manuel
Director(s): Borrás Blasco, Consuelo; Viña Ribes, Jose; Mas Bargues, Cristina
Date of the defense: 16/09/2022
University: Univeridad de Valencia

Title: Estudio comparativo de los efectos del ejercicio físico de baja intensidad, de la estimulación magnética transcraneal y de la terapia con oxígeno hiperbárico en mujeres con fibromialgia. Ensayo clínico aleatorizado
Doctoral candidate: Izquierdo Alventosa, Ruth
Director(s): Inglés de la Torre, Marta; Serra Añó, Pilar; Cortés Amador, Sara
Date of the defense: 14/01/2022
University: Univeridad de Valencia

Title: Transcriptómica en centenarios: un ejemplo de envejecimiento satisfactorio
Doctoral candidate: Dromant Jarque, Mar
Director(s): Inglés De La Torre, Marta; Borrás Blasco, Consuelo; Viña Ribes, José
Date of the defense: 21/12/2021
University: Universitat de València

Title: Eficacia de la terapia manual en pacientes con migraña
Doctoral candidate: Muñoz Gómez, Elena
Director(s): Inglés De La Torre, Marta; Espí López, Gemma Victoria
Date of the defense: 23/04/2021
University: Universitat de València

Title: Efecto de la activación del receptor PPARy/RxR como posible tratamiento de la enfermedad de Alzheimer. Papel de la genisteína
Doctoral candidate: Muñoz Cebriá, José Enrique
Director(s): Viña, José; Borrás, Consuelo; Gambini, Juan
Date of the defense: 01/07/2020
University: Universitat de València

Title: Development of an ultrasound-based muscle texture analysis as a potential imaging biomarker for frailty phenotype
Doctoral candidate: Mirón Mombiela, Rebeca
Director(s): Borrás Blasco, Consuelo; Forner Giner, Juana
Date of the defense: 28/01/2019
University: Universitat de València