Dr. Felipe Javier Chaves Martínez

Principal Investigator
Genomics and Diabetes Unit

Presentation

Principal
Investigator
Dr. Felipe Javier Chaves Martínez

felipe.chaves@uv.es

Publications
Association between exposure to air pollution and blood lipids in the general population of Spain. Valdés S, Doulatram-Gamgaram V, Maldonado-Araque C, Garcia-Escobar E, Garcia-Serrano S, Oualla-Bachiri W, Garcia-Vivanco M, Garrido J, Gil V, Martin-Llorente F, Calle-Pascual A, Castaño L, Delgado E, Menéndez E, Franch-Nadal J, Gaztambide S, Girbés J, Chaves F, Galán-García J, Aguilera-Venegas G, Vallvé J, Amigó N, Guardiola M, Ribalta J, Rojo-Martínez G. European Journal of Clinical Investigation. 2023 Oct 5:e14101. doi: 10.1111/eci.14101. PMID: 37795744

Corrigendum to Genetic interaction in the association between oxidative stress and diabetes in the Spanish population [Free Radic. Biol. Med. 205 (2023) 62-68]. Melero R, Quiroz-Rodríguez ME, Lara-Hernández F, Redón J, Sáez G, Briongos-Figuero LS, Abadía-Otero J, Martín-Escudero JC, Chaves FJ, Ayala G, García-García AB. Free Radical Biology & Medicine. 2023 Jul 22;207:181-182. doi: 10.1016/j.freeradbiomed.2023.07.017. PMID: 37487450

Cross-sectional association between severe periodontitis and diabetes mellitus: a nation-wide cohort study. Montero E, Bujaldón R, Montanya E, Calle-Pascual A, Rojo-Martínez G, Castaño L, Franch-Nadal J, Delgado E, Chaves F, Alonso B, Sanz M, Herrera D. Journal of Clinical Periodontology. 2023 Dec 23. doi: 10.1111/jcpe.13937. PMID: 38140803

Dynamics of Human Anelloviruses in plasma and clinical outcomes following kidney transplantation. Forque L, Fernandez-Ruiz M, Albert E, Gimenez E, Monzo C, Chaves J, Redondo N, Rodriguez-Goncer I, Ruiz-Merlo T, Parra P, Andres A, Aguado JM, Navarro D. Transplantation. 2023 Feb 1;107(2):511-520. doi: 10.1097/TP.0000000000004292. PMID: 36042550

High miR-126-3p levels associated with cardiovascular events in a general population. Martinez-Arroyo O, Ortega A, Flores-Chova A, Sanchez-Garcia B, Garcia-Garcia A, Chaves F, Martin-Escudero J, Forner M, Redon J, Cortes R. European Journal of Internal Medicine. 2023 Jul;113:49-56. doi: 10.1016/j.ejim.2023.04.013. PMID: 37080818

Metabolomic patterns, redox-related genes and metals, and bone fragility endpoints in the Hortega Study. Galvez-Fernandez M, Rodriguez-Hernandez Z, Grau-Perez M, Chaves F, Garcia-Garcia A, Amigo N, Monleon D, Garcia-Barrera T, Gomez-Ariza J, Briongos-Figuero L, Perez-Castrillon J, Redon J, Tellez-Plaza M, Martin-Escudero J. Free Radical Biology & Medicine. 2023 Jan;194:52-61. doi: 10.1016/j.freeradbiomed.2022.11.007. PMID: 36370960

Molecular research on genes involved in metabolic diseases. Lara-Hernandez F, Alvarez L, Chaves J, Garcia-Garcia A. Biomedicines. 2023 Jun 9;11(6):1671. doi: 10.3390/biomedicines11061671. PMID: 37371766

A very rare variant in SREBF2, a possible cause of hypercholesterolemia and increased glycemic levels. Garcia-Garcia A, Martinez-Hervas S, Vernia S, Ivorra C, Pulido I, Martin-Escudero J, Casado M, Carretero J, Real J, Chaves F. Biomedicines. 2022 May 19;10(5):1178. doi: 10.3390/biomedicines10051178. PMID: 35625914

Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study). Valdes S, Doulatram-Gamgaram V, Maldonado-Araque C, Lago-Sampedro A, Garcia-Escobar E, Garcia-Serrano S, Garcia-Vivanco M, Juan L, Theobald M, Gil V, Martin-Llorente F, Ocon P, Calle-Pascual A, Castano L, Delgado E, Menendez E, Franch-Nadal J, Gaztambide S, Girbes J, Chaves F, Galan-Garcia J, Aguilera-Venegas G, Gutierrez-Repiso C, Fernandez-Garcia J, Colomo N, Soriguer F, Garcia-Fuentes E, Rojo-Martinez G. Environmental Health. 2022 Aug 17;21(1):76. doi: 10.1186/s12940-022-00889-1. PMID: 35978396

Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega Follow-up Study. Usategui-Martin R, Perez-Castrillon J, Mansego M, Lara-Hernandez F, Manzano I, Briongos L, Abadia-Otero J, Martin-Vallejo J, Garcia-Garcia A, Martin-Escudero J, Chaves F. Gene. 2022 Jan 30;809:146036. doi: 10.1016/j.gene.2021.146036. PMID: 34688818

Developing a simple and practical decision model to predict the risk of incident type 2 diabetes among the general population: The Di@bet.es Study. Martinez-Hervas S, Morales-Suarez-Varela MM, Andres-Blasco I, Lara-Hernandez F, Peraita-Costa I, Real JT, Garcia-Garcia AB, Chaves FJ. European Journal of Internal Medicine. 2022 Aug;102:80-87. doi: 10.1016/j.ejim.2022.05.005. PMID: 35570127

Gene-environment interaction analysis of redox-related metals and genetic variants with plasma metabolic patterns in a general population from Spain: the Hortega Study. Galvez-Fernandez M, Sanchez-Saez F, Domingo-Relloso A, Rodriguez-Hernandez Z, Tarazona S, Gonzalez-Marrachelli V, Grau-Perez M, Morales-Tatay J, Amigo N, Garcia-Barrera T, Gomez-Ariza J, Chaves F, Garcia-Garcia A, Melero R, Tellez-Plaza M, Martin-Escudero J, Redon J, Monleon D. Redox Biology. 2022 Jun;52:102314. doi: 10.1016/j.redox.2022.102314. PMID: 35460952

Genetic variants in obesity-related genes and the risk of osteoporotic fracture. The Hortega Follow-up Study. Usategui-Martin R, Perez-Castrillon J, Briongos-Figuero L, Abadia-Otero J, Lara-Hernandez F, Garcia-Sorribes S, Martin-Vallejo J, Garcia-Garcia A, Chaves F, Martin-Escudero J. Frontiers in Bioscience-Landmark. 2022 Jan 18;27(1):32. doi: 10.31083/j.fbl2701032. PMID: 35090337

Serum vascular endothelial growth factor b and metabolic syndrome incidence in the population based cohort Di@bet.es study. Lago-Sampedro A, Lhamyani S, Valdes S, Colomo N, Maldonado-Araque C, Gonzalez-Molero I, Doulatram-Gamgaram V, Delgado E, Chaves F, Castano L, Calle-Pascual A, Franch-Nadal J, Rojo-Martinez G, Garcia-Serrano S, Garcia-Escobar E. International Journal of Obesity. 2022 Nov;46(11):2013-2020. doi: 10.1038/s41366-022-01212-1. PMID: 35987953

Association between long term exposure to particulate matter and incident hypertension in Spain. Doulatram-Gamgaram V, Valdes S, Maldonado-Araque C, Lago-Sampedro A, Badia-Guillen R, Garcia-Escobar E, Garcia-Serrano S, Garcia-Vivanco M, Garrido JL, Theobald MR, Gil V, Martin-Llorente F, Calle-Pascual A, Bordiu E, Castano L, Delgado E, Franch-Nadal J, Chaves FJ, Montanya E, Galan-Garcia JL, Aguilera-Venegas G, Soriguer F, Rojo-Martinez G. Scientific Reports. 2021 Oct 5;11(1):19702. doi: 10.1038/s41598-021-99154-7. PMID: 34611240

Benchmarking different approaches for Norovirus genome assembly in metagenome samples. Fuentes-Trillo A, Monzo C, Manzano I, Santiso-Bellon C, da Silva Ribeiro de Andrade J, Gozalbo-Rovira R, Garcia-Garcia AB, Rodriguez-Diaz J, Chaves FJ. BMC Genomics. 2021 Nov 24;22(1):849. doi: 10.1186/s12864-021-08067-2. PMID: 34819031

Diversity and dynamic changes of Anelloviruses in plasma following Allogeneic Hematopoietic Stem Cell Transplantation. Gimenez Quiles E, Monzo Cataluña C, Albert Vicent E, Fuentes Trillo A, Seda García E, Pinana J, Hernandez Boluda J, Solano Vercet C, Chaves Martínez F, Navarro Ortega D. Journal of Medical Virology. 2021 Aug;93(8):5167-5172. doi: 10.1002/jmv.26661. PMID: 33174620

Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study. Garcia-Escobar E, Valdes S, Soriguer F, Vendrell J, Urrutia-Etxebarria I, Maldonado-Araque C, Ortega E, Ocon P, Montanya E, Menendez E, Lago-Sampedro A, Gonzalez-Frutos T, Gomis R, Goday A, Garcia-Serrano S, Galan-Garcia J, Castell C, Bordiu E, Badia R, Aguilera-Venegas G, Girbes J, Gaztambide S, Delgado E, Chaves F, Castano L, Calle-Pascual A, Rojo-Martinez G, Franch-Nadal J. Scientific Reports. 2021 Aug 12;11(1):16453. doi: 10.1038/s41598-021-95546-x. PMID: 34385479

Iodine Deficiency and Mortality in Spanish Adults. Di@bet.es study. Maldonado-Araque C, Valdes S, Badia-Guillen R, Lago-Sampedro A, Colomo N, Garcia-Fuentes E, Gutierrez-Repiso C, Goday-Arno A, Calle-Pascual A, Castano L, Castell C, Delgado Alvarez E, Menendez Torre E, Franch-Nadal J, Gaztambide S, Girbes J, Chaves Martínez F, Soriguer F, Rojo-Martinez G. Thyroid. 2021 Jan;31(1):106-114. doi: 10.1089/thy.2020.0131. PMID: 32781944

Thyroid hormone resistance index and mortality in euthyroid subjects: Di@bet.es study. Alonso SP, Valdes S, Maldonado-Araque C, Lago A, Ocon P, Calle A, Castano L, Delgado E, Menendez E, Franch-Nadal J, Gaztambide S, Girbes J, Chaves F, Garcia-Serrano S, Garcia-Escobar E, Fernandez-Garcia JC, Olveira G, Colomo N, Rojo-Martinez G. European Journal of Endocrinology. 2021 Dec 1;186(1):95-103. doi: 10.1530/EJE-21-0640. PMID: 34735370

Urinary exosomal miR-146a as a marker of albuminuria, activity changes and disease flares in lupus nephritis. Perez Hernandez J, Martínez Arroyo O, Ortega Gutiérrez A, Galera Martos M, Solis Salguero M, Chaves Martínez F, Redón Mas J, Forner Giner M, Cortés Vergaz R. Journal Of Nephrology. 2021 Aug;34(4):1157-1167. doi: 10.1007/s40620-020-00832-y. PMID: 32803682

Urinary- and Plasma-Derived Exosomes Reveal a Distinct MicroRNA Signature Associated With Albuminuria in Hypertension. Perez-Hernandez J, Riffo-Campos A, Ortega A, Martinez-Arroyo O, Perez-Gil D, Olivares D, Solaz E, Martinez F, Martinez-Hervas S, Chaves F, Redon J, Cortes R. Hypertension. 2021 Mar 3;77(3):960-971. doi: 10.1161/HYPERTENSIONAHA.120.16598. PMID: 33486986

Projects
Reference: PI21/00506
Title: Estudio multifactorial para la identificación de nuevos factores genéticos y no genéticos mediante la secuenciación del exoma y técnicas de inteligencia artificial
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Javier Chaves Martínez
Duration: 2022 – 2024
Total budget: 183.920 €
Reference: PMP21/00076
Title: ImpactT2D: una estrategia genómica para implementar medicina de precisión en la diabetes tipo 2
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Javier Chaves Martínez
Duration: 2022 – 2025
Total budget: 106.700 €
Reference: COV20/00279
Title: Detección y caracterización rápida de COVID19 y del paciente
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Javier Chaves Martínez
Duration: 2020 – 2021
Total budget: 175.000 €
Reference: PI17/00544
Title: Identificación de variantes genéticas protectoras frente al desarrollo de diabetes tipo 2 en octogenarios
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Javier Chaves Martínez
Duration: 2018 – 2021
Total budget: 196.020 €
+ Info
Title: Development of bioinformatics tools for the characterization of B cell neoplasms
Doctoral candidate: Fuentes Trillo, Azahara Maria
Director(s): Chaves Martínez, Felipe Javier; Navarro Cubells, Blanca; Terol Casterá, María José
Date of the defense: 10/03/2023
University: Universitat de València

Title: Mgviz: desarrollo e integración de métodos de análisis y visualización de datos genómicos en biomedicina
Doctoral candidate: Juanes Tebar, Jose Miguel
Director(s): Chaves Martínez, Felipe Javier; Marín García, Pablo; Arnau Llombart, Vicente
Date of the defense: 22/03/2021
University: Universitat de València

Title: Identificación de variantes genéticas relacionadas con diabetes mellitus tipo 2 en población española
Doctoral candidate: Lendínez Tortajada, Verónica
Director(s): Chaves Martínez, Felipe Javier; Real Collado, Jose Tomás
Date of the defense: 31/01/2020
University: Universitat de València

Title: Exome sequencing in gastrointestinal food allergy induced by multiple food protein
Doctoral candidate: Sanchis Juan, Alba
Director(s): Chaves Martínez, Felipe Javier; Marín García, Pablo; García García, Ana-Bárbara; Gadea Vacas, José
Date of the defense: 10/12/2019
University: Universitat Politècnica de València