Dr. Jose Luis García Giménez

Principal Investigator
Research Group on Epigenomics and Translational Epigenetics

Presentation

Principal
Investigator
Dr. Jose Luis García Giménez

j.luis.garcia@uv.es

Publications
Alterations in leukocyte DNA methylome are associated to immunosuppression in severe clinical phenotypes of septic patients. Beltran-Garcia J, Casabo-Valles G, Osca-Verdegal R, Navarrete-Lopez P, Rodriguez-Gimillo M, Nacher-Sendra E, Ferrando-Sanchez C, Garcia-Lopez E, Pallardo F, Carbonell N, Mena-Molla S, Garcia-Gimenez J. Frontiers in Immunology. 2024 Jan 3:14:1333705. doi: 10.3389/fimmu.2023.1333705. PMID: 38235139

miRNAs Related to Immune Checkpoint Inhibitor Response: a systematic review. García-Giménez J, Saadi W, Ortega A, Lahoz A, Suay G, Carretero J, Pereda J, Fatmi A, Pallardó F, Mena-Molla S. International Journal of Molecular Sciences. 2024 Feb 1;25(3):1737. doi: 10.3390/ijms25031737. PMID: 38339019

Oxidative stress and metabolism meet epigenetic modulation in physical exercise. Garcia-Gimenez J, Canovas-Cervera I, Pallardo F. Free Radical Biology & Medicine. 2024 Jan 8:213:123-137. doi: 10.1016/j.freeradbiomed.2024.01.008. PMID: 38199289

Age-Related microRNA overexpression in Lafora disease male mice provides links between neuroinflammation and oxidative stress. Roma-Mateo C, Lorente-Pozo S, Marquez-Thibaut L, Moreno-Estelles M, Garces C, Gonzalez D, Lahuerta M, Aguado C, Garcia-Gimenez JL, Sanz P, Pallardo FV. International Journal of Molecular Sciences. 2023 Jan 6;24(2):1089. doi: 10.3390/ijms24021089. PMID: 36674605

Extracellular histones trigger oxidative stress-dependent induction of the NF-kB/CAM pathway via TLR4 in endothelial cells. Perez-Cremades D, Bueno-Beti C, Garcia-Gimenez J, Ibanez-Cabellos J, Pallardo F, Hermenegildo C, Novella S. Journal of Physiology and Biochemistry. 2023 May;79(2):251-260. doi: 10.1007/s13105-022-00935-z. PMID: 36464762

Oxidative stress and epigenetics: miRNA involvement in rare autoimmune diseases. Ibanez-Cabellos J, Pallardo F, Garcia-Gimenez J, Seco-Cervera M. Antioxidants. 2023 Mar 25;12(4):800. doi: 10.3390/antiox12040800. PMID: 37107175

The intricate role of non-coding RNAs in sepsis-associated disseminated intravascular coagulation. Canovas Cervera I, Nacher Sendra E, Osca Verdegal R, Dolz Andres E, Beltran Garcia J, Rodriguez Gimillo M, Ferrando Sanchez C, Carbonell N, Garcia Gimenez JL. International Journal of Molecular Sciences. 2023 Jan 30;24(3):2582. doi: 10.3390/ijms24032582. PMID: 36768905

Utility of exome sequencing for the diagnosis of pediatric-onset neuromuscular diseases beyond diagnostic yield: a narrative review. Piñeros-Fernández MC, Morte B, García-Giménez JL. Neurological Sciences. 2023 Nov 22. doi: 10.1007/s10072-023-07210-z. PMID: 37989827

Validation of circulating histone detection by mass spectrometry for early diagnosis, prognosis, and management of critically ill septic patients. Garcia-Gimenez J, Garcia-Lopez E, Mena-Molla S, Beltran-Garcia J, Osca-Verdegal R, Nacher-Sendra E, Aguado-Velasco C, Casabo-Valles G, Roma-Mateo C, Rodriguez-Gimillo M, Antunez O, Ferreres J, Pallardo F, Carbonell N. Journal of Translational Medicine. 2023 May 23;21(1):344. doi: 10.1186/s12967-023-04197-1. PMID: 37221624

Characterization of Early Peripheral Immune Responses in Patients with Sepsis and Septic Shock. Beltran-Garcia J, Osca-Verdegal R, Javega B, Herrera G, O’Connor J, Garcia-Lopez E, Casabo-Valles G, Rodriguez-Gimillo M, Ferreres J, Carbonell N, Pallardo F, Garcia-Gimenez J. Biomedicines. 2022 Feb 23;10(3):525. doi: 10.3390/biomedicines10030525. PMID: 35327327

CIBERER: Spanish national network for research on rare diseases: a highly productive collaborative initiative. Luque J, Mendes I, Gomez B, Morte B, de Heredia M, Herreras E, Corrochano V, Bueren J, Gallano P, Artuch R, Fillat C, Perez-Jurado L, Montoliu L, Carracedo A, Millan J, Webb S, Palau F, Lapunzina P, Pallardo Calatayud F, CIBERER Network. Clinical Genetics. 2022 May;101(5-6):481-493. doi: 10.1111/cge.14113. PMID: 35060122

Clinical and immunological aspects of microRNAs in neonatal sepsis. Fatmi A, Chabni N, Cernada M, Vento M, Gonzalez-Lopez M, Aribi M, Pallardo FV, Garcia-Gimenez JL. Biomedicine & Pharmacotherapy. 2021 Nov 19;145:112444. doi: 10.1016/j.biopha.2021.112444. PMID: 34808550

Extracellular histones activate endothelial NLRP3 inflammasome and are associated with a severe sepsis phenotype. Beltrán-García J, Osca-Verdegal R, Pérez-Cremades D, Novella S, Hermenegildo C, Pallardó FV, García-Giménez JL. Journal of Inflammation Research. 2022 Jul 25;15:4217-4238. doi: 10.2147/JIR.S363693. PMID: 35915852

Histone citrullination mediates a protective role in endothelium and modulates inflammation. Osca-Verdegal R, Beltran-Garcia J, Paes A, Nacher-Sendra E, Novella S, Hermenegildo C, Carbonell N, Garcia-Gimenez J, Pallardo F. Cells. 2022 Dec 15;11(24):4070. doi: 10.3390/cells11244070. PMID: 36552833

Identification of circulating miRNAs differentially expressed in patients with Limb-girdle, Duchenne or facioscapulohumeral muscular dystrophies. Garcia-Gimenez JL, Garcia-Trevijano ER, Aviles-Alia AI, Ibanez-Cabellos JS, Bovea-Marco M, Bas T, Pallardo FV, Vina JR, Zaragoza R. Orphanet Journal of Rare Diseases. 2022 Dec 27;17(1):450. doi: 10.1186/s13023-022-02603-3. PMID: 36575500

Long non-coding RNAs as epigenetic regulators of immune checkpoints in cancer immunity. Saadi W, Fatmi A, Pallardo FV, Garcia-Gimenez JL, Mena-Molla S. Cancers. 2022 Dec 28;15(1):184. doi: 10.3390/cancers15010184. PMID: 36612180

MicroRNA-132 is overexpressed in fetuses with late-onset fetal growth restriction. Morales-Rosello J, Loscalzo G, Garcia-Lopez E, Garcia-Gimenez J, Perales-Marin A. Health Science Reports. 2022 Mar 15;5(2):e558. doi: 10.1002/hsr2.558. PMID: 35317418

MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction. Morales-Rosello J, Loscalzo G, Garcia-Lopez EM, Ibanez Cabellos JS, Garcia-Gimenez JL, Canada Martinez AJ, Perales Marin A. Epigenetics. 2022 Nov;17(11):1345-1356. doi: 10.1080/15592294.2021.2023271. PMID: 34969362

Neurodevelopmental outcome and epigenetic changes at 2 years associated with the oxygen load received upon postnatal stabilization: a pilot study. Lorente-Pozo S, Boronat N, Parra-Llorca A, Lara-Canton I, Solaz-Garcia A, Soler J, Buso E, Casabo-Valles G, Garcia-Gimenez J, Pallardo F, Vento M. Neonatology. 2022;119(5):575-584. doi: 10.1159/000525305. PMID: 35760056

The endothelial glycocalyx and neonatal sepsis. Fatmi A, Saadi W, Beltran-Garcia J, Garcia-Gimenez JL, Pallardo FV. International Journal of Molecular Sciences. 2022 Dec 26;24(1):364. doi: 10.3390/ijms24010364. PMID: 36613805

The genetic diversity and dysfunctionality of catalase associated with a worse outcome in Crohn’s Disease. Iborra M, Moret I, Buso E, Garcia-Gimenez J, Ricart E, Gisbert J, Cabre E, Esteve M, Marquez-Mosquera L, Garcia-Planella E, Guardiola J, Pallardo F, Serena C, Algaba-Chueca F, Domenech E, Nos P, Beltran B. International Journal of Molecular Sciences. 2022 Dec 14;23(24):15881. doi: 10.3390/ijms232415881. PMID: 36555526

Use of circular RNAs in diagnosis, prognosis and therapeutics of renal cell carcinoma. Osca Verdegal R, Beltran Garcia J, Gorriz J, Jabaloyas J, Pallardo F, Garcia Gimenez J. Frontiers in Cell and Developmental Biology. 2022 Jun 22;10:879814. doi: 10.3389/fcell.2022.879814. PMID: 35813211

Comparative analysis of chromatin-delivered biomarkers in the monitoring of sepsis and septic shock: a pilot study. Beltran-Garcia J, Manclus J, Garcia-Lopez E, Carbonell N, Ferreres J, Rodriguez-Gimillo M, Garces C, Pallardo F, Garcia-Gimenez J, Montoya A, Roma-Mateo C. International Journal of Molecular Sciences. 2021 Sep 14;22(18):9935. doi: 10.3390/ijms22189935. PMID: 34576097

DNA Methylation Analysis to Unravel Altered Genetic Pathways Underlying Early Onset and Late Onset Neonatal Sepsis. A Pilot Study. Lorente-Pozo S, Navarrete P, Garzón MJ, Lara-Cantón I, Beltrán-García J, Osca-Verdegal R, Mena-Mollá S, García-López E, Vento M, Pallardó FV, García-Giménez JL. Frontiers in Immunology. 2021 Feb 15;12:622599. doi: 10.3389/fimmu.2021.622599. PMID: 33659006

Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers. Garcia-Gimenez J, Mena-Molla S, Tarazona-Santabalbina F, Vina J, Gomez-Cabrera M, Pallardo F. International Journal of Environmental Research and Public Health. 2021 Feb 15;18(4):1883. doi: 10.3390/ijerph18041883. PMID: 33672064

Overexpression of microRNAs miR-25-3p, miR-185-5p and miR-132-3p in Late Onset Fetal Growth Restriction, Validation of Results and Study of the Biochemical Pathways Involved. Loscalzo G, Scheel J, Ibañez-Cabellos JS, García-Lopez E, Gupta S, García-Gimenez JL, Mena-Mollá S, Perales-Marín A, Morales-Roselló J. International Journal of Molecular Sciences. 2021 Dec 28;23(1):293. doi: 10.3390/ijms23010293. PMID: 35008715

Oxidative stress and rare diseases: from molecular crossroads to therapeutic avenues. Roma-Mateo C, Garcia-Gimenez J. Antioxidants. 2021 Apr 16;10(4):617. doi: 10.3390/antiox10040617. PMID: 33923815

Role of microRNAs as biomarkers in sepsis-associated encephalopathy. Osca-Verdegal R, Beltran-Garcia J, Pallardo FV, Garcia-Gimenez JL. Molecular Neurobiology. 2021 Sep;58(9):4682-4693. doi: 10.1007/s12035-021-02445-3. PMID: 34160774

Role of non-coding RNAs as biomarkers of deleterious cardiovascular effects in sepsis. Beltran Garcia J, Osca Verdegal R, Nacher Sendra E, Cardona Monzonis A, Sanchis Gomar F, Carbonell N, Pallardo FV, Lavie CJ, Garcia Gimenez JL. Progress in Cardiovascular Diseases. 2021;68:70-77. doi: 10.1016/j.pcad.2021.07.005. PMID: 34265333

Projects
Reference: CPP2021-008643
Title: Identificación y validación de biomarcadores mediante el uso de las ómicas y la Inteligencia Artificial para el diagnóstico temprano y mejora del manejo clínico de la sepsis
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Edurne Carbonell
Duration: 2022 – 2024
Total budget: 150.269 €
Reference: DTS21/00193
Title: Test basados en péptidos spike-in y espectrometría de masas para la cuantificación de histonas circulantes y proteína APC, para el manejo clínico del paciente crítico
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Jose Luis García Giménez
Duration: 2022 – 2023
Total budget: 122.100 €
Reference: FIPSE 3819-21
Title: Valorización e internacionalización de HistShock, un test IVD para el diagnóstico y pronóstico de la sepsis y el shock séptico
Funding body: Fundación para la Innovación y Prospectiva en Salud en España (FIPSE)
Principal Investigator: José Luis García Giménez
Duration: 2021 – 2021
Total budget: 30.000 €
Reference: PI19/00994
Title: Biomarcadores epigenéticos en sepsis y su implicación en inmunosupresión y futuras comorbilidades en supervivientes
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: José Luis García Giménez
Duration: 2020 – 2022
Total budget: 111.320 €
Reference: INNTA2/2020/4
Title: Incorporación de investigadores y tecnólogos para proyectos de innovación en empresas
Funding body: Agencia Valenciana de Innovación (AVI)
Principal Investigator: José Luis García Giménez
Duration: 2020 – 2021
Total budget: 33.013 €
Reference: INNVA1/2020/85
Title: Valorización, estrategia de protección y transferencia de un método de diagnóstico y pronóstico de la sepsis y el shock séptico
Funding body: Agencia Valenciana de la Innovación-AVI Generalitat Valenciana
Principal Investigator: Jose Luis García Giménez
Duration: 2020 – 2021
Total budget: 110.670 €
Reference: ACCI-2018
Title: Validación de biomarcadores para el diagnóstico y el pronóstico de la sepsis neonatal
Funding body: CIBER de Enfermedades Raras (CIBERER-ISCIII)
Principal Investigator: José Luis García Giménez
Duration: 2019 – 2020
Total budget: 49.500 €
Reference: PI16/01036
Title: Epigenética e inmunosupresión. Uso de las histonas circulantes y sus modificaciones posttraduccionales como biomarcadores de diagnóstico y pronóstico en sepsis y shock séptico
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: José Luis García Giménez
Duration: 2017 – 2019
Total budget: 87.725 €
+ Info
Title: Identificación de los mecanismos epigenéticos relacionados con los fenómenos de inmunosupresión en sepsis y su uso como biomarcadores de pronóstico
Doctoral candidate: Osca Verdegal, Rebeca
Director(s):
Date of the defense: 19/05/2023
University: University de Valencia

Title: Potencial uso de la tecnología basada en microARNs para el diagnóstico y pronóstico de la escoliosis idiopática del adolescente
Doctoral candidate: Berenguer Pascual, Ester
Director(s): García Giménez, José Luis; Pérez Machado, Giselle; Mena Mollá Salvador
Date of the defense: 10/02/2022
University: Universitat de València

Title: Uso de las histonas circulantes y sus modificaciones post-traduccionales como biomarcadores en sepsis y shock séptico
Doctoral candidate: Beltrán García, Jesús
Director(s): García Giménez, José Luis; Pallardó Calatayud, Federico
Date of the defense: 20/01/2022
University: Universitat de València

Title: Influencia de factores epigeneticos en el desarrollo de la escoliosis idiopatica del adolescente
Doctoral candidate: Rubio Belmar, Pedro Antonio
Director(s): Bas Hermida, Teresa; García Giménez, José Luis
Date of the defense: 27/05/2021
University: Universitat de València

Title: Búsqueda de MIARNS en fluido crevicular gingival: expresión diferencial en sujetos con periodontitis crónica avanzada
Doctoral candidate: Almiñana Pastor, Pedro José
Director(s): García Giménez, José Luis; Bagán Sebastián, Jose Vicente; López Roldán, Andrés
Date of the defense: 04/03/2021
University: Universitat de València