Research Group on Vascular Function

Cardiovascular Area

Vascular changes associated with different pathologies

Regulation of blood flow

Coordinatora
Dr. José Mª Vila Salinas
jose.m.salinas@uv.es

Coordinatora
Dra. Mª Dolores Mauricio Aviñó
m.dolores.mauricio@uv.es

RESEARCHERS
Leading, R4

José Mª Vila Salinas    
Mª Dolores Mauricio Aviñó    

Established, R3

Víctor Manuel Víctor González
Martín Aldasoro Celaya

Recognised/Emerging, R2

Solanye Guerra Ojeda
Susana Rovira Llopis

First Stage, R1

Andrea Suárez Fortea
Begoña Belmonte Alonso
Clara Luna Marco

STAFF
Collaborating Researchers
Nurse
Technicians
Administrative assistant
Publications
Cardiovascular benefits of SGLT2 inhibitors and GLP-1 receptor agonists through effects on mitochondrial function and oxidative stress. Luna-Marco C, Iannantuoni F, Hermo-Argibay A, Devos D, Salazar J, Victor V, Rovira-Llopis S. Free Radical Biology & Medicine. 2024 Jan 12:213:19-35. doi: 10.1016/j.freeradbiomed.2024.01.015. PMID: 38220031

Anti-inflammatory and immunomodulating effects of rilpivirine: relevance for the therapeutics of chronic liver disease. Moragrega A, Gruevska A, Fuster-Martinez I, Benedicto A, Tosca J, Monton C, Victor V, Esplugues J, Blas-Garcia A, Apostolova N. Biomedicine & Pharmacotherapy. 2023 Nov:167:115537. doi: 10.1016/j.biopha.2023.115537. PMID: 37738799

Circadian alignment of food intake and glycaemic control by time-restricted eating: A systematic review and meta-analysis. Rovira-Llopis S, Luna-Marco C, Perea-Galera L, Bañuls C, Morillas C, Victor VM. Reviews in Endocrine & Metabolic Disorders. 2023 Nov 22. doi: 10.1007/s11154-023-09853-x. PMID: 37993559

Effects of GLP-1 receptor agonists on mitochondrial function, inflammatory markers and leukocyte-endothelium interactions in type 2 diabetes. Luna-Marco C, de Maranon A, Hermo-Argibay A, Rodriguez-Hernandez Y, Hermenejildo J, Fernandez-Reyes M, Apostolova N, Vila J, Sola E, Morillas C, Rovira-Llopis S, Rocha M, Victor V. Redox Biology. 2023 Aug 14;66:102849. doi: 10.1016/j.redox.2023.102849. PMID: 37591012

Glucose 6-P dehydrogenase overexpression improves aging-induced endothelial dysfunction in aorta from mice: role of arginase II. Serna E, Mauricio MD, San Miguel T, Guerra Ojeda S, Verdu D, Valls A, Arc-Chagnaud C, De la Rosa A, Vina J. International Journal of Molecular Sciences. 2023 Feb 11;24(4):3622. doi: 10.3390/ijms24043622. PMID: 36835034

Improvement of vascular insulin sensitivity by ranolazine. Guerra-Ojeda S, Jorda A, Aldasoro C, Vila J, Valles S, Arias-Mutis O, Aldasoro M. International Journal of Molecular Sciences. 2023 Aug 31;24(17):13532. doi: 10.3390/ijms241713532. PMID: 37686345

Inflammation and lipid metabolism as potential biomarkers of memory impairment across type 2 diabetes mellitus and severe mental disorders. Sanchez-Orti J, Correa-Ghisays P, Balanza-Martinez V, Selva-Vera G, Vila-Frances J, Magdalena-Benedito R, San-Martin C, Victor V, Escribano-Lopez I, Hernandez-Mijares A, Vivas-Lalinde J, Crespo-Facorro B, Tabares-Seisdedos R. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2023 Jun 15;127:110817. doi: 10.1016/j.pnpbp.2023.110817. PMID: 37327846

Mitochondrial dysfunction and mitophagy in type 2 diabetes: pathophysiology and therapeutic targets. Apostolova N, Vezza T, Muntane J, Rocha M, Victor V. Antioxidants & Redox Signaling. 2023 Aug;39(4-6):278-320. doi: 10.1089/ars.2022.0016. PMID: 36641637

SIRT1 and miR-34a-5p: valuable biomarkers for the early detection of cognitive impairment in Type 2 Diabetes Mellitus. Vezza T, Victor V. Journal of Clinical Endocrinology & Metabolism. 2023 Dec 16:dgad740. doi: 10.1210/clinem/dgad740. PMID: 38104246

The role of aryl hydrocarbon receptor in the endothelium: a systematic review. Guerra-Ojeda S, Suarez A, Valls A, Verdu D, Pereda J, Ortiz-Zapater E, Carretero J, Mauricio M, Serna E. International Journal of Molecular Sciences. 2023 Aug 31;24(17):13537. doi: 10.3390/ijms241713537. PMID: 37686342

Cerium dioxide nanoparticles modulate antioxidant defences and change vascular response in the human saphenous vein. Guerra-Ojeda S, Marchio P, Rueda C, Suarez A, Garcia H, Victor V, Juez M, Martin-Gonzalez I, Vila J, Mauricio M. Free Radical Biology & Medicine. 2022 Nov 17;193(Pt 2):694-701. doi: 10.1016/j.freeradbiomed.2022.11.012. PMID: 36402438

Deleterious effects of levamisole, a cocaine adulterant, in rabbit aorta. Guerra-Ojeda S, Marchio P, Aldasoro M, Valles S, Genoves P, Mauricio M, Vila J. Vascular Pharmacology. 2022 Jun;144:106992. doi: 10.1016/j.vph.2022.106992. PMID: 35358704

EpCAM and microvascular obstruction in patients with STEMI: a cardiac magnetic resonance study. Rios-Navarro C, Gavara J, Nunez J, Revuelta-Lopez E, Monmeneu JV, Lopez-Lereu MP, de Dios E, Perez-Sole N, Vila JM, Oltra R, Chorro FJ, Bayes-Genis A, Bodi V. Revista Espanola de Cardiologia (English ed.). 2022 May;75(5):384-391. doi: 10.1016/j.rec.2021.04.006. PMID: 34045168

Facilitation of insulin effects by ranolazine in astrocytes in primary culture. Jorda A, Aldasoro M, Campo-Palacio I, Vila JM, Aldasoro C, Campos-Campos J, Colmena C, Singh SK, Obrdor E, Valles SL. International Journal of Molecular Sciences. 2022 Oct 9;23(19):11969. doi: 10.3390/ijms231911969. PMID: 36233271

Glycated proteins, glycine, acetate, and monounsaturated fatty acids may act as new biomarkers to predict the progression of type 2 diabetes: secondary analyses of a randomized controlled trial. Canet F, Christensen J, Victor V, Hustad K, Ottestad I, Rundblad A, Sather T, Dalen K, Ulven S, Holven K, Telle-Hansen V. Nutrients. 2022 Dec 5;14(23):5165. doi: 10.3390/nu14235165. PMID: 36501195

Gold nanoparticles supported on ceria nanoparticles modulate leukocyte-endothelium cell interactions and inflammation in Type 2 Diabetes. Diaz-Pozo P, Canet F, Grirrane A, Lopez-Domenech S, Herance J, Apostolova N, Luna-Marco C, Rovira-Llopis S, Marti M, Morillas C, Rocha M, Garcia H, Victor V. Antioxidants. 2022 Nov 20;11(11):2297. doi: 10.3390/antiox11112297. PMID: 36421483

Immune-inflammatory biomarkers predict cognition and social functioning in patients with Type 2 Diabetes Mellitus, major depressive disorder, bipolar disorder, and schizophrenia: a 1-year follow-up study. Gares-Caballer M, Sanchez-Orti J, Correa-Ghisays P, Balanza-Martinez V, Selva-Vera G, Vila-Frances J, Magdalena-Benedito R, San-Martin C, Victor V, Escribano-Lopez I, Hernandez-Mijares A, Vivas-Lalinde J, Vieta E, Leza J, Tabares-Seisdedos R. Frontiers in Neurology. 2022 Jun 2;13:883927. doi: 10.3389/fneur.2022.883927. PMID: 35720107

Impact of nitric oxide in liver cancer microenvironment. Dios-Barbeito S, Gonzalez R, Cadenas M, Garcia L, Victor V, Padillo F, Muntan J. Nitric Oxide-Biology and Chemistry. 2022 Aug 5;128:1-11. doi: 10.1016/j.niox.2022.07.006. PMID: 35940533

Impact of Roux-en-Y gastric bypass on mitochondrial biogenesis and dynamics in leukocytes of obese women. Abad-Jimenez Z, Vezza T, Lopez-Domenech S, Fernandez-Reyes M, Canet F, Morillas C, Gomez-Abril S, Banuls C, Victor V, Rocha M. Antioxidants. 2022 Jun 29;11(7):1302. doi: 10.3390/antiox11071302. PMID: 35883794

Metformin modulates mitochondrial function and mitophagy in peripheral blood mononuclear cells from type 2 diabetic patients. de Maranon A, Diaz-Pozo P, Canet F, Diaz-Morales N, Abad-Jimenez Z, Lopez-Domenech S, Vezza T, Apostolova N, Morillas C, Rocha M, Victor V. Redox Biology. 2022 Jul;53:102342. doi: 10.1016/j.redox.2022.102342. PMID: 35605453

Metformin: an intriguing protective agent in hospitalized diabetic patients with sepsis. Vezza T, Victor V. Critical Care Medicine. 2022 Jun 1;50(6):1018-1020. doi: 10.1097/CCM.0000000000005480. PMID: 35612442

Mitochondrial redox impairment and enhanced autophagy in peripheral blood mononuclear cells from type 1 diabetic patients. Canet F, Diaz-Pozo P, Luna-Marco C, Fernandez-Reyes M, Vezza T, Marti M, Salazar J, Roldan I, Morillas C, Rovira-Llopis S, Rocha M, Victor V. Redox Biology. 2022 Dec;58:102551. doi: 10.1016/j.redox.2022.102551. PMID: 36455476

Protective action of ultrasound-guided electrolysis technique on the muscle damage induced by notexin in rats. Jorda A, Campos-Campos J, Aldasoro C, Colmena C, Aldasoro M, Alvarez K, Valles SL. PLoS One. 2022 Nov 28;17(11):e0276634. doi: 10.1371/journal.pone.0276634. PMID: 36441673

Specific metabolic syndrome components predict cognition and social functioning in people with type 2 diabetes mellitus and severe mental disorders. Sanchez-Orti J, Balanza-Martinez V, Correa-Ghisays P, Selva-Vera G, Vila-Frances J, Magdalena-Benedito R, San-Martin C, Victor V, Escribano-Lopez I, Hernandez-Mijares A, Vivas-Lalinde J, Crespo-Facorro B, Tabares-Seisdedos R. Acta Psychiatrica Scandinavica. 2022 Sep;146(3):215-226. doi: 10.1111/acps.13433. PMID: 35359023

The role of mitochondrial dynamic dysfunction in age-associated type 2 diabetes. Vezza T, Diaz-Pozo P, Canet F, Maranon AM, Abad-Jimenez Z, Garcia-Gargallo C, Roldan I, Sola E, Banuls C, Lopez-Domenech S, Rocha M, Victor VM. World Journal of Mens Health. 2022 Jul;40(3):399-411. doi: 10.5534/wjmh.210146. PMID: 35021300

Transdiagnostic neurocognitive deficits in patients with type 2 diabetes mellitus, major depressive disorder, bipolar disorder, and schizophrenia: a 1-year follow-up study. Correa-Ghisays P, Sanchez-Orti JV, Balanza-Martinez V, Selva-Vera G, Vila-Frances J, Magdalena-Benedito R, Victor VM, Escribano-Lopez I, Hernandez-Mijares A, Vivas-Lalinde J, San-Martin C, Crespo-Facorro B, Tabares-Seisdedos R. Journal of Affective Disorders. 2022 Mar 1;300:99-108. doi: 10.1016/j.jad.2021.12.074. PMID: 34965401

Inflammatory chemokines expression variations and their receptors in APP/PS1 mice. Jorda A, Aldasoro M, Aldasoro C, Valles S. Journal of Alzheimers Disease. 2021;83(3):1051-1060. doi: 10.3233/JAD-210489. PMID: 34397415

Ischemia-reperfusion injury to coronary arteries: comprehensive microscopic study after reperfused myocardial infarction. Rios-Navarro C, Daugbouche-Rubio N, Gavara J, de Dios E, Perez N, Vila JM, Chorro FJ, Ruiz-Sauri A, Bodi V. Annals of Anatomy. 2021 Nov;238:151785. doi: 10.1016/j.aanat.2021.151785. PMID: 34144157

Overexpression of genes involved in lymphocyte activation and regulation are associated with reduced CRM-derived cardiac remodelling after STEMI. de Dios E, Rios-Navarro C, Perez-Sole N, Gavara J, Marcos-Garces V, Forteza M, Oltra R, Vila J, Chorro F, Bodi V. International Immunopharmacology. 2021 Mar 4;95:107490. doi: 10.1016/j.intimp.2021.107490. PMID: 33677257

PPARgamma as an indicator of vascular function in an experimental model of metabolic syndrome in rabbits. Guerra-Ojeda S, Marchio P, Gimeno-Raga M, Arias-Mutis O, San-Miguel T, Valles S, Aldasoro M, Vila J, Zarzoso M, Mauricio M. Atherosclerosis. 2021 Aug 5;332:16-23. doi: 10.1016/j.atherosclerosis.2021.08.006. PMID: 34375909

Role of antiangiogenic VEGF-A165b in angiogenesis and systolic function after reperfused myocardial infarction. Rios Navarro C, Hueso Soler L, Diaz Cuevas A, Marcos Garcés V, Bonanad Lozano C, Ruiz Sauri A, Vila Salinas J, Sanz Ferrando M, Chorro Gascó F, Piqueras Ruiz L, Bodí Peris V. Revista espanola de Cardiologia (English ed.). 2021 Feb;74(2):131-139. doi: 10.1016/j.rec.2020.03.013. PMID: 32474003

The HIF1 alpha-PFKFB3 pathway: a key player in diabetic retinopathy comment. Vezza T, Victor VM. Journal of Clinical Endocrinology & Metabolism. 2021 Oct 21;106(11):e4778-e4780. doi: 10.1210/clinem/dgab469. PMID: 34171101

Projects
Reference: PI22/00424
Title: Nuevas perspectivas en la relación mitofagia, autofagia y disfunción mitocondrial en la diabetes tipo 2: implicaciones clínicas y complicaciones cardiovasculares asociadas
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Víctor Manuel Víctor González
Duration: 2023 – 2025
Total budget: 171.820,00 €
Reference: PROMETEO/2019/027
Title: Patofisiología de las enfermedades cardiometabólicas
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Víctor Manuel Víctor González
Duration: 2020 – 2023
Total budget: 207.157,00 €
Reference: PI19/00838
Title: Estudio de la función mitocondrial, la autofagia y la mitofagia en la diabetes tipo 2: relación con las complicaciones cardiovasculares e implicaciones clínicas
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Víctor Manuel Víctor González
Duration: 2020 – 2022
Total budget: 183.920,00 €
+ Info
Title: Estudio del efecto de la cirugía de bypass gástrico en Y de Roux sobre los mecanismos moleculares asociados a la fisiopatología de la obesidad
Doctoral candidate: Abad Jiménez, Zaida María
Director(s): Víctor González, Víctor Manuel
Date of the defense: 22/12/2022
University: Universitat de València

Title: Interacciones de la ranolazina con agentes vasoactivos endógenos y exógenos.
Doctoral candidate: Campos Carot, Elena
Director(s): Vila Salinas, José Mª; Mauricio Aviñó, Mª Dolores; Martínez León, Juan B
Date of the defense: 19/12/2022
University: Universitat de València

Title: Efectos vasculares de las nanopartículas de óxido de cerio en la vena safena
Doctoral candidate: Rueda Muñoz, Cristina
Director(s): Mauricio Aviñó, Mª Dolores; Juez López Marina; Guerra Ojeda Solanye
Date of the defense: 28/10/2022
University: Universitat de València

Title: Study of mitochondrial dynamics and function and autophagy and their relationship with cardiovascular complications in type 2
Doctoral candidate: Martínez de Marañón Peris, Aránzazu
Director(s): Víctor González, Víctor Manuel; Rocha Barajas, Milagros; Martí Cabrera, Miguel
Date of the defense: 20/12/2021
University: Universitat de València

Title: Estudio de los mecanismos de estrés oxidativo, activación del inflamasoma NLRP3 y las interacciones leucocito-endotelio en la diabetes: efectos del papel de la empagliflozina
Doctoral candidate: Iannantuoni, Francesca
Director(s): Víctor González, Víctor Manuel; Rocha Barajas, Milagros
Date of the defense: 22/06/2021
University: Universitat de València

Title: Alteraciones vasculares inducidas por un modelo de síndrome metabólico en conejo
Doctoral candidate: Gimeno Raga, Marc
Director(s): Aldasoro Celaya, Martín; Valles Martín, Lilian Soraya; Mauricio Aviñó, María Dolores
Date of the defense: 03/05/2019
University: Universitat de València