Research Group in Medical Chemistry for Drug Development
Metabolism and Organic Damage Area
Peroxisome proliferator activator receptors (PPARs)
Liver X receptors (LXR)
Dopamine receptors
Biomarkers of inflammation
Coordinatora
STAFF
Collaborating Researchers
Diego Cortés MartínezJordi Ferri Císcar
Nurse
Technicians
Laura Vila Dasí
Administrative assistant
Publications
Remission of graves disease after initiation of ocrelizumab in patients with multiple sclerosis. Casany-Fernandez R, Gascon-Gimenez F, Matarredona Solaz E, Pardo Lozano F, Dominguez-Moran J, Ferri Ciscar J, Real J. Thyroid. 2023 Feb;33(2):267-269. doi: 10.1089/thy.2022.0398. PMID: 36416241
Synthesis of 2-aminopropyl benzopyran derivatives as potential agents against triple-negative breast cancer. García A, Torres-Ruiz S, Vila L, Villarroel-Vicente C, Bernabeu A, Eroles P, Cabedo N, Cortes D. RSC Medicinal Chemistry. 2023 Oct 4;14(11):2327-2341. doi: 10.1039/d3md00385j. PMID: 38020071
Effect of personality on blood glucose control in patients with type 1 diabetes. Gu Hong W, Ferri J, Ampudia-Blasco F, Martin-Brufau R, Peiro M, Benito E, Martinez-Hervas S, Sanz M, Real J. Endocrinologia, Diabetes y Nutricion. 2022 Nov;69(9):677-685. doi: 10.1016/j.endien.2021.11.034. PMID: 36470643
Synthesis and biological studies of polycerasoidol and trans-delta-tocotrienolic acid derivatives as PPARalpha and/or PPARgamma agonists. Vila L, Cabedo N, Villarroel-Vicente C, Garcia A, Bernabeu A, Hennuyer N, Staels B, Franck X, Figadere B, Sanz MJ, Cortes D. Bioorganic & Medicinal Chemistry. 2022 Jan 1;53:116532. doi: 10.1016/j.bmc.2021.116532. PMID: 34863066
Synthesis of 2-prenylated alkoxylated benzopyrans by horner- wadsworth-emmons olefination with PPAR alpha/gamma agonist activity. Garcia A, Vila L, Marin P, Bernabeu A, Villarroel-Vicente C, Hennuyer N, Staels B, Franck X, Figadere B, Cabedo N, Cortes D. ACS Medicinal Chemistry Letters. 2021 Oct 6;12(11):1783-1786. doi: 10.1021/acsmedchemlett.1c00400. PMID: 34795868
Projects
Title: Desarrollo de nuevos moduladores multidiana de receptores nucleares y biomarcadores lipídicos para el tratamiento del síndrome metabólico y las comorbilidades asociadas
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Nuria Cabedo Escrig
Duration: 2022 – 2024
Total budget: 174.240 €
Title: Desarrollo químico y farmacológico de nuevos fármacos “multidiana” en el tratamiento de la diabetes mellitus tipo 2 y la enfermedad cardiovascular asociada
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Nuria Cabedo Escrig
Duration: 2019 – 2022
Total budget: 61.710 €
Title: Multi-target paradigm for innovative ligand identification in the drug discovery process (MuTaLig)
Funding body: European Commission
Principal Investigator: Stefano Alcaro
Duration: 2016 – 2020
Total budget:
Title: Synthesis and pharmacological evaluation of new dual PPARalpha/gamma agonists as new therapeutic tools in the control of cardiometabolic disorders
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Nuria Cabedo Escrig
Duration: 2016 – 2021
Total budget: 121.500 €