Research Group on Molecular Imaging and Metabolomics
Oncology Area
Identify new metabolomic markers of tumor aggressiveness in brain cancer
Identify new markers of myocardial infarction
Identify new metabolomic cardiovascular risk markers based on the microbiota-host interaction
Coordinator
STAFF
Collaborating Researchers
Nurse
Technicians
Jose Francisco Haro EstévezLaura Moreno Morcillo
Administrative assistant
Publications
Cardiovascular risk of metabolically healthy obesity in two european populations: prevention potential from a metabolomic study. Wei D, Gonzalez-Marrachelli V, Melgarejo J, Liao C, Hu A, Janssens S, Verhamme P, Van Aelst L, Vanassche T, Redon J, Tellez-Plaza M, Martin-Escudero J, Monleon D, Zhang Z. Cardiovascular Diabetology. 2023 Apr 7;22(1):82. doi: 10.1186/s12933-023-01815-6. PMID: 37029406
Gut-derived metabolites mediating cognitive development in 5-year-old children: Early-life transplant in mice has lasting effects throughout adulthood. Guzzardi M, La Rosa F, Granziera F, Panetta D, Pardo-Tendero M, Barone M, Turroni S, Faita F, Kusmic C, Brigidi P, Monleon D, Iozzo P. Brain, Behavior, and Immunity. 2023 Aug 7;114:94-110. doi: 10.1016/j.bbi.2023.08.009. PMID: 37557963
Impact of maternal weight gain on the newborn metabolome. Guixeres-Esteve T, Ponce-Zanon F, Morales J, Lurbe E, Alvarez-Pitti J, Monleon D. Metabolites. 2023 Apr 15;13(4):561. doi: 10.3390/metabo13040561. PMID: 37110219
Metabolic effects of early life stress and pre-pregnancy obesity are long-lasting and sex-specific in mice. Brix L, Monleon D, Collado M, Ederveen T, Toksoz I, Bordes J, van Doeselaar L, Engelhardt C, Mitra S, Narayan S, Schmidt M. The European Journal of Neuroscience. 2023 Jul;58(1):2215-2231. doi: 10.1111/ejn.16047. PMID: 37203224
Gene-environment interaction analysis of redox-related metals and genetic variants with plasma metabolic patterns in a general population from Spain: the Hortega Study. Galvez-Fernandez M, Sanchez-Saez F, Domingo-Relloso A, Rodriguez-Hernandez Z, Tarazona S, Gonzalez-Marrachelli V, Grau-Perez M, Morales-Tatay J, Amigo N, Garcia-Barrera T, Gomez-Ariza J, Chaves F, Garcia-Garcia A, Melero R, Tellez-Plaza M, Martin-Escudero J, Redon J, Monleon D. Redox Biology. 2022 Jun;52:102314. doi: 10.1016/j.redox.2022.102314. PMID: 35460952
Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain. Delgado-Velandia M, Gonzalez-Marrachelli V, Domingo-Relloso A, Galvez-Fernandez M, Grau-Perez M, Olmedo P, Galan I, Rodriguez-Artalejo F, Amigo N, Briongos-Figuero L, Redon J, Martin-Escudero J, Monleon-Salvado D, Tellez-Plaza M, Sotos-Prieto M. International Journal of Behavioral Nutrition and Physical Activity. 2022 Jan 27;19(1):8. doi: 10.1186/s12966-021-01219-3. PMID: 35086546
Lipoprotein profiles of fat distribution and its association with insulin sensitivity. Wei D, Marrachelli V, Melgarejo J, Liao C, Janssens S, Verhamme P, Vanassche T, Van Aelst L, Monleon D, Redon J, Zhang Z. Frontiers in Endocrinology. 2022 Oct 25;13:978745. doi: 10.3389/fendo.2022.978745. PMID: 36387872
Liver and white/brown fat dystrophy associates with gut microbiota and metabolomic alterations in 3xTg Alzheimer’s Disease mouse model. Guzzardi M, La Rosa F, Campani D, Collado M, Monleon D, Insilla A, Tripodi M, Zega A, Dattilo A, Brunetto M, Maffei M, Bonino F, Iozzo P. Metabolites. 2022 Mar 22;12(4):278. doi: 10.3390/metabo12040278. PMID: 35448465
Bacterial metabolites trimethylamine N-oxide and butyrate as surrogates of small intestinal bacterial overgrowth in patients with a recent decompensated heart failure. Mollar A, Marrachelli V, Nunez E, Monleon D, Bodi V, Sanchis J, Navarro D, Nunez J. Scientific reports. 2021 Mar 17;11(1):6110. doi: 10.1038/s41598-021-85527-5. PMID: 33731747
Dental stem cell signaling pathway activation in response to hydraulic calcium silicate-based endodontic cements: A systematic review of in vitro studies. Sanz J, Rodriguez-Lozano F, Lopez-Gines C, Monleon D, Llena C, Forner L. Dental materials. 2021 Apr;37(4):e256-e268. doi: 10.1016/j.dental.2021.01.025. PMID: 33573840
Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus. Borras C, Abdelaziz KM, Diaz A, Gambini J, Jove M, Lopez-Grueso R, Mas-Bargues C, Monleon D, Pamplona R, Vina J. Mechanisms of Ageing and Development. 2021 Dec;200:111596. doi: 10.1016/j.mad.2021.111596. PMID: 34774606
Moderate Red Wine Consumption Increases the Expression of Longevity-Associated Genes in Controlled Human Populations and Extends Lifespan in Drosophila melanogaster. Gambini J, Gimeno-Mallench L, Olaso-Gonzalez G, Mastaloudis A, Traber M, Monleon D, Borras C, Vina J. Antioxidants. 2021 Feb 16;10(2):301. doi: 10.3390/antiox10020301. PMID: 33669360
Projects
Title: Metabolómica automatizada de alto rendimiento para estudios epidemiológicos, búsqueda de biomarcadores y ‘big data’
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Daniel Monleón Salvadó
Duration: 2021 – 2023
Total budget: 148.572 €
Title: Efecto del tratamiento con vesículas extracelulares de células madre de grasa de ratones jóvenes sobre parámetros de envejecimiento y fragilidad en ratones de edad avanzada
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Consuelo Borrás Blasco
Duration: 2021 – 2024
Total budget: 181.500 €
Title: BREIC: Identificación de biomarcadores del eje corazón-microbiota-sistema inmune por rmn para la estratificación de pacientes con insuficiencia cardiaca
Funding body: Universidad de Valencia – INCLIVA
Principal Investigator: Vannina González Marrachelli, Anna Mollar Fernández
Duration: 2021 – 2022
Total budget: 4.750 €
Title: Metabolomic study of mechanisms for Se-related diabetes and insulin resistance
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Daniel Monleón Salvadó, Mónica Simón García
Duration: 2020 – 2023
Total budget: 140000
Title: Nuevos nanomateriales como agentes de contraste en IRM y desarrollo de la plataforma de RMN para estudios biomedicos mediante histología correlativa
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: José Manuel Morales Tatay
Duration: 2018 – 2019
Total budget: 9.500 €
Title: Modelos predictivos en insuficiencia cardíaca con FE preservada-intermedia a partir de información de los registros electrónicos de salud. Valor aditivo de marcadores de metabolómica
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Vannina González Marrachelli
Duration: 2018 – 2020
Total budget: 24.200 €
Title: Obesidad materna y disfunción cognitiva en la descendencia: papel causa-efecto de la microbiota intestinal y prevención dietética temprana
Funding body: Ministerio de Economía y Competitividad
Principal Investigator: Consuelo Borrás Blasco
Duration: 2017 – 2022
Total budget: 143.000 €
Title: GUTMOM: Maternal obesity and cognitive dysfunction in the offspring: cause-effect role of the GUT MicrobiOMe and early dietary prevention
Funding body: European Commission. JPI HDHL
Principal Investigator: Patricia Lozzo
Duration: 2017 – 2020
Total budget: 778.240 €
Title: A multidisciplinary Project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Vicente Bodí Peris
Duration: 2016 – 2019
Total budget: 589.050 €
+ Info
Doctoral candidate: Pisoni, Serena
Director(s): González Marrachelli, Vannina; Monleon Salvado, Daniel; Di Blasio, Anna Maria
Date of the defense: 12/05/2023
University: Universitat de València
Title: Detección de nuevos marcadores asociados a daño por reperfusión y fibrosis infarto de miocardio validados histopatológicamente mediante análisis multivariante de resonancia magnética multimodal
Doctoral candidate: Pérez Terol, Itziar
Director(s): Monleón Salvadó, Daniel; Morales Tatay, José Manuel
Date of the defense: 21/07/2022
University: Universitat de València
Title: Estudio metabolómico en tejido prostático y orina para el diagnóstico y pronóstico del cáncer de próstata
Doctoral candidate: Panach Navarrete, Jorge
Director(s): Martínez Jabaloyas, José María; Morales Tatay, José Manuel; González Marrachelli Vannina
Date of the defense: 08/04/2022
University: Universitat de València
Title: Estudio metabolómico de la interacción huesped-microbiota intestinal en la enfermedad cardiometabólica. Detección temprana, prevención y tratamiento
Doctoral candidate: Pardo Tendero, María Mercedes
Director(s): Monleón Salvado, Daniel; González Marrachelli, Vannina
Date of the defense: 25/06/2021
University: Universitat de València