{"id":7398,"date":"2025-04-10T09:06:28","date_gmt":"2025-04-10T09:06:28","guid":{"rendered":"https:\/\/tst.incliva.es\/?page_id=7398"},"modified":"2025-04-10T09:06:28","modified_gmt":"2025-04-10T09:06:28","slug":"research-group-on-nuclear-receptors-in-cardiometabolic-pathology","status":"publish","type":"page","link":"https:\/\/tst.incliva.es\/en\/que-hacemos\/areas\/metabolismo-y-dano-organico\/research-group-on-nuclear-receptors-in-cardiometabolic-pathology\/","title":{"rendered":"Research Group on Nuclear Receptors in Cardiometabolic Pathology"},"content":{"rendered":"

\n
\n

Research Group on Nuclear Receptors in Cardiometabolic Pathology<\/h3>\n<\/div>\n
<\/div><\/div>\n
Metabolism and Organic Damage Area<\/span><\/h5>\n<\/div>\n
<\/div><\/div>\n
\n
\n Identification of new mechanisms involved in angiogenesis and inflammation in obese patients <\/p>\n

– Study and characterization of the role of the CCR4 receptor and its ligands CCL17 \/ TARCE, CCL22 \/ MDC and CKLF1 in angiogenesis and inflammation associated with obesity and in response to bariatric surgery <\/p>\n

– Characterization of the role of constitutive nuclear receptors for androstane (CAR) in endothelial dysfunction and angiogenesis associated with obesity and in response to bariatric surgery <\/p>\n

Identification of new mechanisms involved in angiogenesis and inflammation in acute myocardial infarction. Role of the anti-angiogenic isoform VEGF165b <\/p>\n

– Determination of VEGF-A165b levels in patients with STEMI and its relationship with microvascular obstruction <\/p>\n

– To study the effects of neutralization of the VEGF-165b isoform in a mouse model with acute infarction <\/p>\n

Study of the role of the SGLT2 transporter in the development of abdominal aortic aneurysm <\/p>\n

– To evaluate the effect of empagliflozin, an inhibitor of SGLT2, in an animal model of abdominal aortic aneurysm and to investigate the possible anti-inflammatory effect of empagliflozin in dysfunction endothelial
\n\n<\/div>\n<\/div>\n<\/div><\/div>