Grupo de Investigación en Salud de la Mujer

Área de Medicina Reproductiva

El grupo se posiciona en el campo del envejecimiento saludable, particularmente en lo relacionado con la mujer, con especial interés en la fragilidad, donde ha colaborado en el apoyo de INCLIVA en el proyecto VENTAJA

Hemos colaborado para posicionar el sitio de referencia de la Comunidad Valenciana dentro de EIPAHA, el partenariado de la Comisión Europea

Además, hemos participado en la solicitud a diferentes proyectos europeos con grupos de diferentes países europeos, incluyendo una solicitud a las becas Maire Curie

Coordinador
Dr. Antonio Cano Sánchez
antonio.cano@uv.es; acano@uv.es

INVESTIGADORES
R4 Senior

Antonio Cano Sánchez    
Juan José Tarín Folgado

R3 Consolidado
R2 Novel / Emergente

Loreto Suay Llopis

R1 Predoctoral
STAFF
Colaborador/a

Aitana Monllor Tormos
Rocío Belda Montesinos

Enfermero/a

Alicia García Vigara

Técnico/a
Apoyo
Publicaciones
Allelic variants of the estrogen receptor genes and frailty phenotype in postmenopausal women. Monllor-Tormos A, García-Vigara A, Morgan O, García-Pérez M, Tarín J, Cano A. Climacteric. 2024 Feb 6:1-7. doi: 10.1080/13697137.2024.2306269. PMID: 38318796

Fezolinetant impact on health-related quality of life for vasomotor symptoms due to the menopause: pooled data from SKYLIGHT 1 and SKYLIGHT 2 randomised controlled trials. Cano A, Nappi R, Santoro N, Stute P, Blogg M, English M, Morga A, Scrine L, Siddiqui E, Ottery F. BJOG-An International Journal of Obstetrics and Gynaecology. 2024 Feb 6. doi: 10.1111/1471-0528.17773. PMID: 38320967

Both reduced ovarian reserve and severe semen alterations are overrepresented in couples seeking assisted reproductive technology treatment for the first time: a cross-sectional study. Tarin J, Pascual E, Garcia-Perez M, Monllor-Tormos A, Cano A. Reproductive Health. 2023 Aug 16;20(1):117. doi: 10.1186/s12978-023-01666-0. PMID: 37582738

Breaking down barriers for prescribing and using hormone therapy for the treatment of menopausal symptoms: an experts’ perspective. Rozenberg S, Panay N, Gambacciani M, Cano A, Gray S, Schaudig K. Expert Review of Clinical Pharmacology. 2023 Jan-Jun;16(6):507-517. doi: 10.1080/17512433.2023.2219056. PMID: 37278023

Corrigendum to «Evaluation of the impact, treatment patterns, and patient and physician perceptions of vasomotor symptoms associated with menopause in Europe and the United States» [Maturitas 164 (October 2022) 38-45]. Stute P, Cano A, Thurston RC, Small M, Lee L, Scott M, Siddiqui E, Schultz NM. Maturitas. 2023 Mar;169:55. doi: 10.1016/j.maturitas.2022.11.003. PMID: 36435689

Fezolinetant for treatment of moderate-to-severe vasomotor symptoms associated with menopause (SKYLIGHT 1): a phase 3 randomised controlled study. Lederman S, Ottery F, Cano A, Santoro N, Shapiro M, Stute P, Thurston R, English M, Franklin C, Lee M, Neal-Perry G. Lancet. 2023 Apr 1;401(10382):1091-1102. doi: 10.1016/S0140-6736(23)00085-5. PMID: 36924778

Genetic variants of the vitamin D receptor are related to dynapenia in postmenopausal women. Garcia-Vigara A, Monllor-Tormos A, Garcia-Perez M, Tarin J, Cano A. Maturitas. 2023 May;171:40-44. doi: 10.1016/j.maturitas.2023.03.002. PMID: 37001478

Long-term effect of chemotherapy after ovarian decortication on the ovarian function in women surviving cancer. Ortiz E, Peña C, Hidalgo J, Monllor-Tormos A, Zolfaroli I, Vila M, Sánchez-Serrano M, Pellicer A, Cano A. Journal of Assisted Reproduction and Genetics. 2023 Sep 27. doi: 10.1007/s10815-023-02949-y. PMID: 37755614

Mediterranean diet for cancer prevention and survivorship. Monllor-Tormos A, Garcia-Vigara A, Morgan O, Garcia-Perez M, Mendoza N, Tarin J, Cano A. Maturitas. 2023 Dec:178:107841. doi: 10.1016/j.maturitas.2023.107841. PMID: 37660598

Pharmacological interactions and menopausal hormone therapy: a review. Fasero M, Quereda F, Andraca L, Coronado P, HT Eligibility Criteria Grp. Menopause-Journal of the North American Menopause Society. 2023 Aug 1;30(8):873-880. doi: 10.1097/GME.0000000000002219. PMID: 37449718

Prophylactic mastectomy and bilateral salpingo-oophorectomy in patients with breast cancer: a systematic review of postsurgical sexual function and menopausal hormone therapy symptom mitigation. Morgan O, Belda R, Schnur J, Montgomery G, Parmar S, Chirivella I, Cano A. Sexual Medicine Reviews. 2023 Dec 23;12(1):3-13. doi: 10.1093/sxmrev/qead020. PMID: 37183167

Rodent animal models of endometriosis-associated pain: unmet needs and resources available for improving translational research in endometriosis. Tejada MA, Antunez C, Nunez Badinez P, De Leo B, Saunders PT, Vincent K, Cano A, Nagel J, Gomez R. International Journal of Molecular Sciences. 2023 Jan 26;24(3):2422. doi: 10.3390/ijms24032422. PMID: 36768741

Safety of fezolinetant for vasomotor symptoms associated with menopause: a randomized controlled trial. Neal-Perry G, Cano A, Lederman S, Nappi R, Santoro N, Wolfman W, English M, Franklin C, Valluri U, Ottery F. Obstetrics and Gynecology. 2023 Apr 1;141(4):737-747. doi: 10.1097/AOG.0000000000005114. PMID: 36897180

Sequential management of postmenopausal health and osteoporosis: an update. Calaf-Alsina J, Cano A, Guanabens N, Palacios S, Cancelo M, Castelo-Branco C, Larrainzar-Garijo R, Neyro J, Nogues X, Diez-Perez A. Maturitas. 2023 Nov:177:107846. doi: 10.1016/j.maturitas.2023.107846. PMID: 37738717

Sexual perception in spanish female breast cancer survivors. Cross-Sectional Survey. Torres-Balanza S, Fuentes-Aparicio L, Mena-Del Horno S, Martinez-Aspas A, Sempere-Rubio N. Clinical Breast Cancer. 2023 Jan;23(1):15-22. doi: 10.1016/j.clbc.2022.10.011. PMID: 36357269

The covid-19 pandemic and the usability of telehealth in a midlife women’s health integrated care program. Garcia-Vigara A, Martin-Gonzalez V, Carbonell J, Bauset-Castello C, Martinez-Aspas A, Monllor-Tormos A, Garcia-Perez M, Tarin J, Cano A. Maturitas. 2023 Feb;168:7-12. doi: 10.1016/j.maturitas.2022.10.011. PMID: 36370490

Body weight and fat mass across the menopausal transition: hormonal modulators. Moccia P, Belda-Montesinos R, Monllor-Tormos A, Chedraui P, Cano A. Gynecological Endocrinology. 2022 Feb;38(2):99-104. doi: 10.1080/09513590.2021.2004395. PMID: 34898344

Eligibility criteria for Menopausal Hormone Therapy (MHT): a position statement from a consortium of scientific societies for the use of MHT in women with medical conditions. MHT Eligibility Criteria Group. Mendoza N, Ramirez I, de la Viuda E, et al. Maturitas. 2022 Aug 30;166:65-85. doi: 10.1016/j.maturitas.2022.08.008. PMID: 36081216

Evaluation of the impact, treatment patterns, and patient and physician perceptions of vasomotor symptoms associated with menopause in Europe and the United States. Stute P, Cano A, Thurston R, Small M, Lee L, Scott M, Siddiqui E, Schultz N. Maturitas. 2022 Jun 23;164:38-45. doi: 10.1016/j.maturitas.2022.06.008. PMID: 35785563

Histological grade and tumor stage are correlated with expression of receptor activator of nuclear factor Kappa b (Rank) in epithelial ovarian cancers. Gomez R, Tejada M, Rodriguez-Garcia V, Burgues O, Santos-Llamas A, Martinez-Massa A, Marin-Montes A, Tarin J, Cano A. International Journal of Molecular Sciences. 2022 Feb 3;23(3):1742. doi: 10.3390/ijms23031742. PMID: 35163671

Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain. Tejada MA, Santos Llamas A, Escriva L, Tarin JJ, Cano A, Fernandez Ramirez MJ, Nunez Badinez P, De Leo B, Saunders PTK, Vidal V, Barthas F, Vincent K, Sweeney PJ, Sillito RR, Armstrong JD, Nagel J, Gomez R. Biomedicines. 2022 Feb 21;10(2):501. doi: 10.3390/biomedicines10020501. PMID: 35203710

Impact of the COVID-19 pandemic on a cancer fast-track programme. Martinez M, Moragon S, Ortega-Morillo B, Monton-Bueno J, Simon S, Rosello S, Insa A, Viala A, Navarro J, Sanmartin A, Fluixa C, Julve A, Soriano D, Buch E, Pena A, Franco J, Martinez-Jabaloyas J, Marco J, Forner M, Cano A, Silvestre A, Teruel A, Bermejo B, Cervantes A, Chirivella Gonzalez I. Cancer Control. 2022 Jan-Dec;29:10732748221131000. doi: 10.1177/10732748221131000. PMID: 36355430

It is premature to use postmortem sperm for reproductive purposes: a data-driven opinion. Tarin J, Garcia-Perez M, Cano A. Reproductive Sciences. 2022 Dec;29(12):3387-3393. doi: 10.1007/s43032-022-00874-6. PMID: 35146695

Metabolomic analysis of severe osteoarthritis in a Spanish population of women compared to healthy and osteoporotic subjects. Pertusa C, Mifsut D, Morales J, Tarin J, Cano A, Monleon D, Garcia-Perez M. Metabolites. 2022 Jul 24;12(8):677. doi: 10.3390/metabo12080677. PMID: 35893245

Non-use of information and communication technology as a predictor of frailty in postmenopausal midlife and older women. Garcia-Vigara A, Cano A, Fernandez-Garrido J, Carbonell-Asins J, Tarin J, Sanchez-Sanchez M. Maturitas. 2022 Feb;156:60-64. doi: 10.1016/j.maturitas.2021.05.010. PMID: 34275701

Nuts and metabolic syndrome: reducing the burden of metabolic syndrome in menopause. Bauset C, Martinez-Aspas A, Smith-Ballester S, Garcia-Vigara A, Monllor-Tormos A, Kadi F, Nilsson A, Cano A. Nutrients. 2022 Apr 18;14(8):1677. doi: 10.3390/nu14081677. PMID: 35458240

Toward an improved assessment of quality of life in endometriosis: evaluation of the Spanish version of the Endometriosis Health Profile 30. Mari-Alexandre J, Garcia-Oms J, Agababyan C, Belda-Montesinos R, Royo-Bolea S, Varo-Gomez B, Diaz-Sierra C, Gonzalez-Canto E, Gilabert-Estelles J. Journal of Psychosomatic Obstetrics & Gynecology. 2022 Sep;43(3):251-257. doi: 10.1080/0167482X.2020.1795827. PMID: 32735156

A reassessment of the therapeutic potential of a dopamine receptor 2 Agonist (D2-AG) in endometriosis by comparison against a standardized antiangiogenic treatment. Tejada M, Santos-Llamas A, Fernandez-Ramirez M, Tarin J, Cano A, Gomez R. Biomedicines. 2021 Mar 8;9(3):269. doi: 10.3390/biomedicines9030269. PMID: 33800198

Bazedoxifene increases the proliferation of human arterial endothelial cells but does not affect the expression of cyclins A, B, and D1 and of p27(Kip1). Dudenko D, Gomez R, Garcia-Perez M, Tarin J, Cano A. Gynecological Endocrinology. 2021 Mar;37(3):269-272. doi: 10.1080/09513590.2021.1876653. PMID: 33480311

Comparison of IOTA three-step strategy and logistic regression model LR2 for discriminating between benign and malignant adnexal masses. Hidalgo JJ, Llueca A, Zolfaroli I, Veiga N, Ortiz E, Alcazar JL. Medical Ultrasonography. 2021 May 20;23(2):168-175. doi: 10.11152/mu-2732. PMID: 33626112

Female genital mutilation consequences and healthcare received among migrant women: a phenomenological qualitative study. Gonzalez-Timoneda A, Gonzalez-Timoneda M, Cano Sanchez A, Ruiz Ros V. International Journal of Environmental Research and Public Health. 2021 Jul 5;18(13):7195. doi: 10.3390/ijerph18137195. PMID: 34281134

Global consensus recommendations on menopause in the workplace: a European Menopause and Andropause Society (EMAS) position statement. Rees M, Bitzer J, Cano A, Ceausu I, Chedraui P, Durmusoglu F, Erkkola R, Geukes M, Godfrey A, Goulis DG, Griffiths A, Hardy C, Hickey M, Hirschberg AL, Hunter M, Kiesel L, Jack G, Lopes P, Mishra G, Oosterhof H, Pines A, Riach K, Shufelt C, van Trotsenburg M, Weiss R, Lambrinoudaki I. Maturitas. 2021 Sep;151:55-62. doi: 10.1016/j.maturitas.2021.06.006. PMID: 34274202

Management of urinary incontinence in postmenopausal women: An EMAS clinical guide. Russo E, Caretto M, Giannini A, Bitzer J, Cano Sanchez A, Ceausu I, Chedraui P, Durmusoglu F, Erkkola R, Goulis D, Kiesel L, Lambrinoudaki I, Hirschberg A, Lopes P, Pines A, Rees M, van Trotsenburg M, Simoncini T. Maturitas. 10.1016/j.maturitas.2020.09.005. doi: 10.1016/j.maturitas.2020.09.005. PMID: 33008675

Ovarian steroids and cancer: news on the breast, questions on the reproductive tract. Hidalgo-Mora J, Tarin J, Cano A. Gynecological Endocrinology. 2021 May;37(5):383-384. doi: 10.1080/09513590.2021.1904871. PMID: 33825589

Positive association of high-density lipoprotein cholesterol with lumbar and femoral neck bone mineral density in postmenopausal women. Zolfaroli I, Ortiz E, Garcia-Perez M, Hidalgo-Mora J, Tarin J, Cano A. Maturitas. 2021 May;147:41-46. doi: 10.1016/j.maturitas.2021.03.001. PMID: 33832646

Randomized controlled trial for promotion of healthy eating in older adults by increasing consumption of plant-based foods: effect on inflammatory biomarkers. Nilsson A, Cano A, Bergens O, Kadi F. Nutrients. 2021 Oct 24;13(11):3753. doi: 10.3390/nu13113753. PMID: 34836009

Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence. Castelo-Branco C, Gambacciani M, Cano A, Minkin M, Rachon D, Ruan X, Beer A, Schnitker J, Henneicke-von Zepelin H, Pickartz S. Climacteric. 2021 Apr;24(2):109-119. doi: 10.1080/13697137.2020.1820477. PMID: 33021111

Serum microRNAs in osteoporotic fracture and osteoarthritis: a genetic and functional study. Pertusa C, Tarin JJ, Cano A, Garcia-Perez MA, Mifsut D. Scientific Reports. 2021 Sep 29;11(1):19372. doi: 10.1038/s41598-021-98789-w. PMID: 34588560

Ten-year assessment of a cancer fast-track programme to connect primary care with oncology: reducing time from initial symptoms to diagnosis and treatment initiation. Martinez MT, Monton-Bueno J, Simon S, Ortega B, Moragon S, Rosello S, Insa A, Navarro J, Sanmartin A, Julve A, Buch E, Pena A, Franco J, Martinez-Jabaloyas J, Marco J, Forner MJ, Cano A, Silvestre A, Teruel A, Lluch A, Cervantes A, Chirivella Gonzalez I. ESMO open. 2021 May 11;6(3):100148. doi: 10.1016/j.esmoop.2021.100148. PMID: 33989988

The RANKL/RANK system in female reproductive organ tumors: a preclinical and clinical overview. Monzo-Miralles A, Martin-Gonzalez V, Smith-Ballester S, Iglesias-Miguel V, Cano A. Advances in Clinical and Experimental Medicine. 2021 Sep;30(9):879-883. doi: 10.17219/acem/140422. PMID: 34435475

Topical estrogens and non-hormonal preparations for postmenopausal vulvovaginal atrophy: An EMAS clinical guide. Hirschberg AL, Bitzer J, Cano A, Ceausu I, Chedraui P, Durmusoglu F, Erkkola R, Goulis DG, Kiesel L, Lopes P, Pines A, van Trotsenburg M, Lambrinoudaki I, Rees M. Maturitas. 2021 Jun;148:55-61. doi: 10.1016/j.maturitas.2021.04.005. PMID: 33896654

Variants translating reduced expression of the beta estrogen receptor gene were associated with increased carotid intima media thickness: A cross-sectional study in late postmenopausal women. Cano-Marquina AJ, Garcia-Perez MA, Tarin JJ, Maceira AM, Cosin-Sales J, Cano A. Medicine. 2021 Jun 11;100(23):e26216. doi: 10.1097/MD.0000000000026216. PMID: 34115005

Proyectos
Referencia: AC19/00084
Título: Patrones dietéticos en población europea senescente: acercamiento multidisciplinar para combatir las enfermedades metabólicas ligadas a sobrepeso. Proyecto EURODIET
Entidad Financiadora: European Commission (Programación conjunta internacional ISCIII)
Investigador principal: Antonio Cano Sánchez
Duración: 2020 – 2022
Presupuesto: 27225
Referencia: 696300 – EURODIET
Título: EURODIET Dietary Patterns in the Ageing European Population: an Interdisciplinary Approach to combat Overweight-Related Metabolic Diseases. The EURODIET project
Entidad Financiadora: European Commission (Programación conjunta internacional ISCIII)
Investigador principal: Antonio Cano Sánchez
Duración: 2019 – 2020
Presupuesto: 455.915,00 €
Referencia: 826640-VIGOUR
Título: Evidence-Based Guidance to Scale-up Integrated Care in Europe (VIGOUR)
Entidad Financiadora: Agencia Ejecutiva de Consumidores, Salud, Agricultura y Alimentación
Investigador principal: Antonio Cano Sánchez, Juan J. Tarín, Miguel Ángel García Pérez
Duración: 2019 – 2021
Presupuesto: 3.046.024,67
+ Información
Topical estrogens and non-hormonal preparations for postmenopausal vulvovaginal atrophy: An EMAS clinical guide. Hirschberg AL, Bitzer J, Cano A, Ceausu I, Chedraui P, Durmusoglu F, Erkkola R, Goulis DG, Kiesel L, Lopes P, Pines A, van Trotsenburg M, Lambrinoudaki I, Rees M. Maturitas. 2021 Jun;148:55-61. doi: 10.1016/j.maturitas.2021.04.005. PMID: 33896654

Menopause symptom management in women with dyslipidemias: An EMAS clinical guide. Anagnostis P, Bitzer J, Cano Sanchez A, Ceausu I, Chedraui P, Durmusoglu F, Erkkola R, Goulis D, Hirschberg A, Kiesel L, Lopes P, Pines A, van Trotsenburg M, Lambrinoudaki I, Rees M. Maturitas. 2020 May;135:82-88. doi: 10.1016/j.maturitas.2020.03.007. PMID: 32209279

Título: Acción del bazedoxifeno sobre el metabolismo óseo y los factores de riesgo cardiovascular
Doctorando: Carrasco Catena, María Amparo
Director: Cano Sánchez, Antonio; Monleón Sancho, Francisco Javier
Fecha: 20/11/2020
Universidad: Universitat de València

Título: Efectos de las enfermedades de las mujeres sobre resultados FIV/ICSI y la utilización de probabilidades acumuladas de nacimiento vivo como único método de predicción
Doctorando: Pascual Castelló, Eva Cristina
Director: Tarín Folgado, Juan José
Fecha: 05/10/2020
Universidad: Universitat de València

Título: Vivencias en relación con la mutilación genital femenina y capacitación para su abordaje desde los diferentes actores institucionales implicados en valencia
Doctorando: González Timoneda, Alba
Director: Ruiz Ros, Vicente; Cano Sánchez, Antonio
Fecha: 23/07/2020
Universidad: Universitat de València

Título: Impact of bazedoxifene on endothelial health markers
Doctorando: Dudenko Lozenko, Darya
Director: Cano Sánchez, Antonio; Tarín Folgado, Juan José; Gómez Gallego, Raúl
Fecha: 30/06/2020
Universidad: Universitat de València

Título: Tratamiento del mioma con acetato de ulipristal: control evolutivo con ecografía/angiografía tridimensional
Doctorando: Pascual Botía, Carlos
Director: Raga Bauxauli, Francisco; Cano Sánchez, Antonio
Fecha: 13/03/2020
Universidad: Universitat de València

Título: Lipidograma y metabolismo óseo, estudio clínico y analítico en la cohorte «CARMEN»
Doctorando: Zolfaroli, Irene
Director: García Pérez, Miguel Ángel; Cano Sánchez, Antonio
Fecha: 27/02/2019
Universidad: Universitat de València

Título: Evaluación estandarizada del potencial antiangiógénico del agonista dopaminérgico en el tratamiento de la endometriosis
Doctorando: Blanca Ruiz, Taqua
Director: Cano Sánchez, Antonio; Gómez Gallego, Raúl
Fecha: 17/01/2019
Universidad: Universitat de València