Dra. Carmina Montoliu Félix

Investigador Principal
Grupo de Investigación de Deterioro Neurológico

Presentación

Investigador
Principal
Dra. Carmina Montoliu Félix

cmontoliu@incliva.es

Publicaciones
Erythrocytes functionality in SARS-CoV-2 infection: potential link with Alzheimer’s disease. Kosenko E, Tikhonova L, Alilova G, Montoliu C. International Journal of Molecular Sciences. 2023 Mar 17;24(6):5739. doi: 10.3390/ijms24065739. PMID: 36982809

Is NMDA-receptor-mediated oxidative stress in mitochondria of peripheral tissues the essential factor in the pathogenesis of hepatic encephalopathy?. Kosenko E, Tikhonova L, Alilova G, Montoliu C. Journal of Clinical Medicine. 2022 Feb 4;11(3):827. doi: 10.3390/jcm11030827. PMID: 35160278

Matched paired primary and recurrent meningiomas points to cell-death program contributions to genomic and epigenomic instability along tumor progression. San-Miguel T, Megias J, Monleon D, Navarro L, Munoz-Hidalgo L, Montoliu C, Meri M, Roldan P, Cerda-Nicolas M, Lopez-Gines C. Cancers. 2022 Aug 19;14(16):4008. doi: 10.3390/cancers14164008. PMID: 36011000

Metabolic syndrome is associated with poor response to rifaximin in minimal hepatic encephalopathy. Ballester M, Gallego J, Fiorillo A, Casanova-Ferrer F, Gimenez-Garzo C, Escudero-Garcia D, Tosca J, Rios M, Monton C, Durban L, Ballester J, Benlloch S, Urios A, San-Miguel T, Kosenko E, Serra M, Felipo V, Montoliu C. Scientific Reports. 2022 Feb 14;12(1):2463. doi: 10.1038/s41598-022-06416-z. PMID: 35165326

Minimal hepatic encephalopathy is associated to alterations in eye movements. Casanova-Ferrer F, Garcia-Cena CE, Gallego JJ, Fiorillo A, Urios A, Calvo-Cordoba A, Ballester MP, Rios MP, Durban L, Hidalgo MR, Garcia F, Felipo V, Montoliu C. Scientific Reports. 2022 Oct 7;12(1):16837. doi: 10.1038/s41598-022-21230-3. PMID: 36207472

Plasma ammonia levels predict hospitalisation with liver-related complications and mortality in clinically stable outpatients with cirrhosis. Tranah T, Ballester M, Carbonell-Asins J, Ampuero J, Alexandrino G, Caracostea A, Sanchez-Torrijos Y, Thomsen K, Kerbert A, Capilla-Lozano M, Romero-Gomez M, Escudero-Garcia D, Montoliu C, Jalan R, Shawcross D. Journal of Hepatology. 2022 Dec;77(6):1554-1563. doi: 10.1016/j.jhep.2022.07.014. PMID: 35872326

Plasma extracellular vesicles play a role in immune system modulation in minimal hepatic encephalopathy. Gallego J, Fiorillo A, Casanova-Ferrer F, Urios A, Ballester M, Durban L, Megias J, Rubio T, Cabrera-Pastor A, Escudero-Garcia D, Felipo V, Montoliu C. International Journal of Molecular Sciences. 2022 Oct 15;23(20):12335. doi: 10.3390/ijms232012335. PMID: 36293192

A new score unveils a high prevalence of mild cognitive impairment in patients with nonalcoholic fatty liver disease. Gimenez-Garzo C, Fiorillo A, Ballester-Ferre M, Gallego J, Casanova-Ferrer F, Urios A, Benlloch S, Marti-Aguado D, San-Miguel T, Tosca J, Rios M, Monton C, Durban L, Escudero-Garcia D, Aparicio L, Felipo V, Montoliu C. Journal of Clinical Medicine. 2021 Jun 25;10(13):2806. doi: 10.3390/jcm10132806. PMID: 34202269

Multi-omic analysis unveils biological pathways in peripheral immune system associated to minimal hepatic encephalopathy appearance in cirrhotic patients. Rubio T, Felipo V, Tarazona S, Pastorelli R, Escudero-Garcia D, Tosca J, Urios A, Conesa A, Montoliu C. Scientific Reports. 2021 Jan 21;11(1):1907. doi: 10.1038/s41598-020-80941-7. PMID: 33479266

Patients with Minimal Hepatic Encephalopathy Show Altered Thermal Sensitivity and Autonomic Function. Rega D, Aiko M, Penaranda N, Urios A, Gallego J, Gimenez-Garzo C, Casanova F, Fiorillo A, Cabrera-Pastor A, San-Miguel T, Ipiens C, Escudero-Garcia D, Tosca J, Monton C, Ballester M, Ballester J, Aparicio L, Rios M, Durban L, Mir A, Kosenko E, Cases P, Felipo V, Montoliu C. Journal of Clinical Medicine. 2021 Jan 11;10(2):E239. doi: 10.3390/jcm10020239. PMID: 33440769

A Look into Liver Mitochondrial Dysfunction as a Hallmark in Progression of Brain Energy Crisis and Development of Neurologic Symptoms in Hepatic Encephalopathy. Kosenko E, Tikhonova L, Alilova G, Montoliu Félix M. Journal of Clinical Medicine. 2020 Jul 16;9(7):2259. doi: 10.3390/jcm9072259. PMID: 32708652

Extracellular Vesicles from Hyperammonemic Rats Induce Neuroinflammation and Motor Incoordination in Control Rats. Izquierdo-Altarejos P, Cabrera Pastor A, Gonzalez-King H, Montoliu Félix M, Felipo V. Cells. 2020 Feb 28;9(3):572. doi: 10.3390/cells9030572. PMID: 32121257

Hyperammonemia alters the mismatch negativity in the auditory evoked potential by altering functional connectivity and neurotransmission. Garcia-Garcia R, Guerrero J, Lavilla-Miyasato M, Magdalena J, Ordono J, Llansola M, Montoliu Félix M, Teruel-Marti V, Felipo V. Journal of Neurochemistry. 2020 Jul;154(1):56-70. doi: 10.1111/jnc.14941. PMID: 31840253

Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy. San Martín Valenzuela C, Borras-Barrachina A, Gallego Roig J, Urios Lluch M, Mestre Salvador V, Correa Ghisays P, Ballester Ferre M, Escudero Garcia A, Tosca Cuquerella J, Monton Rodríguez C, Rios M, Kosenko E, Felipo V, Tabarés Seisdedos R, Selva Vera G, Montoliu Félix M. Journal of Clinical Medicine. 2020 Jul 8;9(7):2154. doi: 10.3390/jcm9072154. PMID: 32650464

Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-kappa B pathway. Balzano T, Arenas Y, Dadsetan S, Forteza J, Gil-Perotin S, Cubas-Nunez L, Casanova B, Gracia F, Varela-Andres N, Montoliu Félix M, Llansola M, Felipo V. Journal of Neuroinflammation. 2020 Feb 22;17(1):70. doi: 10.1186/s12974-020-01746-z. PMID: 32087723

The Erythrocytic Hypothesis of Brain Energy Crisis in Sporadic Alzheimer Disease: Possible Consequences and Supporting Evidence. Kosenko E, Tikhonova L, Alilova G, Urios Lluch M, Montoliu Félix M. Journal of Clinical Medicine. 2020 Jan 12;9(1):206. doi: 10.3390/jcm9010206. PMID: 31940879

Proyectos
Referencia: PI18/00150
Título: Caracterización de las alteraciones neurológicas y cerebrales en pacientes con encefalopatía hepática mínima. Contribucu¡ión de la Inflamación. Implicaciones diagnósticas y terapéuticas
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Carmina Montoliu Félix
Duración: 2019 – 2021
Presupuesto: 171.820 €
Referencia: PROMETEO/2018/051
Título: Mecanismos moleculares y cerebrales de las alteraciones cognitivas y motoras en hiperamonemia y encefalopatía hepática. lmplicaciones terapéuticas y diagnósticas
Entidad Financiadora: Conselleria de Educación, Cultura y Deporte
Investigador principal: Vicente Felipo Orts
Duración: 2018 – 2021
Presupuesto: 289.194,57
+ Información
Título: Characterization and evaluation of alterations in sensitivity and autonomic function in patients with minimal hepatic encephalopathy
Doctorando: Rega Caballero, Dalia
Director: Montoliu Felix, Carmina; Uriós Lluch, Amparo; Cases Bergón, Paula
Fecha: 05/12/2022
Universidad: Universitat Politècnica de València

Título: Caracterización del deterioro neurológico y la respuesta al tratamiento con rifaximina en pacientes con encefalopatía hepática mínima
Doctorando: Ballester Ferré, Maria Pilar
Director: Montoliu Félix, Carmina; Escudero García, Desamparados; Serra Desfílis Miguel Ángel
Fecha: 08/01/2021
Universidad: Universitat de València