Dr. Ana Lluch Hernández

Principal Investigator
Research Group on Breast Cancer Biology

Presentation

Principal
Investigator
Dr. Ana Lluch Hernández

ana.lluch@uv.es

Publications
Author Correction: Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer. Schettini F, Chic N, Brasó-Maristany F, Paré L, Pascual T, Conte B, Martínez-Sáez O, Adamo B, Vidal M, Barnadas E, Fernández-Martinez A, González-Farre B, Sanfeliu E, Cejalvo JM, Perrone G, Sabarese G, Zalfa F, Peg V, Fasani R, Villagrasa P, Gavilá J, Barrios CH, Lluch A, Martín M, Locci M, De Placido S, Prat A. NPJ Breast Cancer. 2023 Apr 29;9(1):32. doi: 10.1038/s41523-023-00538-x. Erratum for: NPJ Breast Cancer. 2021 Jan 4;7(1):1. PMID: 37120452

Clinical impact of new treatment strategies for HER2-positive metastatic breast cancer patients with resistance to classical Anti-HER therapies. Tapia M, Hernando C, Martínez M, Burgués O, Tebar-Sánchez C, Lameirinhas A, Agreda-Roca A, Torres-Ruiz S, Garrido-Cano I, Lluch A, Bermejo B, Eroles P. Cancers. 2023 Sep 12;15(18):4522. doi: 10.3390/cancers15184522. PMID: 37760491

Delivery of miR-200c-3p using tumor-targeted mesoporous silica nanoparticles for breast cancer therapy. Garrido-Cano I, Adam-Artigues A, Lameirinhas A, Blandez J, Candela-Noguera V, Lluch A, Bermejo B, Sancenon F, Cejalvo J, Martinez-Manez R, Eroles P. ACS Applied Materials & Interfaces. 2023 Aug 16;15(32):38323-38334. doi: 10.1021/acsami.3c07541. PMID: 37549382

Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells. Oltra S, Colomo S, Sin L, Perez-Lopez M, Lazaro S, Molina-Crespo A, Choi K, Ros-Pardo D, Martinez L, Morales S, Gonzalez-Paramos C, Orantes A, Soriano M, Hernandez A, Lluch A, Rojo F, Albanell J, Gomez-Puertas P, Ko J, Sarrio D, Moreno-Bueno G. Cell Death and Differentiation. 2023 May;30(5):1366-1381. doi: 10.1038/s41418-023-01143-y. PMID: 36899106

Dual neoadjuvant blockade plus chemotherapy versus monotherapy for the treatment of women with non-metastatic HER2-positive breast cancer: a systematic review and meta-analysis. Vazquez J, Antolin S, Ruiz-Borrego M, Servitja S, Alba E, Barnadas A, Lluch A, Martin M, Rodriguez-Lescure A, Sola I, Bonfill X, Urrutia G, Sanchez-Rovira P. Clinical & Translational Oncology. 2022 Nov 22. doi: 10.1007/s12094-022-02998-2. PMID: 36417083

High VEGFR3 expression reduces doxorubicin efficacy in triple-negative breast cancer. Torres Ruiz S, Tormo E, Garrido Cano I, Lameirinhas A, Rojo F, Madoz Gurpide J, Burgues O, Hernando C, Bermejo B, Martinez MT, Lluch A, Cejalvo JM, Eroles P. International Journal of Molecular Sciences. 2023 Feb 10;24(4):3601. doi: 10.3390/ijms24043601. PMID: 36835014

miR-146a-5p promotes angiogenesis and confers trastuzumab resistance in HER2+ breast cancer. Cabello P, Torres-Ruiz S, Adam-Artigues A, Fores-Martos J, Martinez M, Hernando C, Zazo S, Madoz-Gurpide J, Rovira A, Burgues O, Rojo F, Albanell J, Lluch A, Bermejo B, Cejalvo J, Eroles P. Cancers. 2023 Apr 4;15(7):2138. doi: 10.3390/cancers15072138. PMID: 37046799

Physicians’ attitudes and perceived barriers to adherence to the national breast cancer clinical practice guidelines in Mexico: a survey study. Martinez-Cannon B, Soto-Perez-de-Celis E, Valle-Solis A, Arce-Salinas C, Bargallo-Rocha E, Bautista-Pina V, Cervantes-Sanchez G, Flores-Balcazar C, Tamburrino M, Lluch A, Maffuz-Aziz A, Perez-Sanchez V, Poitevin-Chacon A, Salas-Gonzalez E, Torres L, Valero V, Villasenor-Navarro Y, Cardenas-Sanchez J. Clinical & Translational Oncology. 2023 Jan;25(1):151-159. doi: 10.1007/s12094-022-02921-9. PMID: 35986133

Real-world use of highly sensitive liquid biopsy monitoring in metastatic breast cancer patients treated with endocrine agents after exposure to aromatase inhibitors. Fuentes-Antrás J, Martínez-Rodríguez A, Guevara-Hoyer K, López-Cade I, Lorca V, Pascual A, de Luna A, Ramirez-Ruda C, Swindell J, Flores P, Lluch A, Cescon D, Pérez-Segura P, Ocana A, Jones F, Moreno F, García-Barberán V, García-Sáenz J. International Journal of Molecular Sciences. 2023 Jul 13;24(14):11419. doi: 10.3390/ijms241411419. PMID: 37511178

The value of sentinel lymph-node biopsy in women with node-positive breast cancer at diagnosis and node-negative tumour after neoadjuvant therapy: a systematic review. Vazquez JC, Pinero A, de Castro FJ, Lluch A, Martin M, Barnadas A, Alba E, Rodriguez-Lescure A, Rojo F, Gimenez J, Sola I, Quintana MJ, Bonfill X, Urrutia G, Sanchez-Rovira P. Clinical & Translational Oncology. 2023 Feb;25(2):417-428. doi: 10.1007/s12094-022-02953-1. PMID: 36153763

Triple negative PAM50 non-basal breast cancer subtype predicts benefit from extended adjuvant capecitabine. Asleh K, Lluch A, Goytain A, Barrios C, Wang X, Torrecillas L, Gao D, Ruiz-Borrego M, Leung S, Bines J, Guerrero-Zotano A, Garcia-Saenz J, Cejalvo J, Herranz J, Torres R, de la Haba-Rodriguez J, Ayala F, Gomez H, Rojo F, Nielsen T, Martin M. Clinical Cancer Research. 2023 Jan 17;29(2):389-400. doi: 10.1158/1078-0432.CCR-22-2191. PMID: 36346687

Development of a Novel NGS methodology for ultrasensitive circulating tumor dna detection as a tool for early-stage breast cancer diagnosis. Jimenez-Rodriguez B, Alba-Bernal A, Lopez-Lopez E, Quiros-Ortega ME, Carbajosa G, Garrido-Aranda A, Alvarez M, Godoy-Ortiz A, Queipo-Ortuno MI, Vicioso L, Diaz-Cordoba G, Roldan-Diaz MD, Velasco-Suelto J, Hernando C, Bermejo B, Julve-Parreno A, Lluch A, Pascual J, Comino-Mendez I, Alba E. International Journal of Molecular Sciences. 2022 Dec 21;24(1):146. doi: 10.3390/ijms24010146. PMID: 36613590

Immunological landscape of HER-2 positive breast cancer. Moragon S, Hernando C, Martinez-Martinez M, Tapia M, Ortega-Morillo B, Lluch A, Bermejo B, Cejalvo J. Cancers. 2022 Jun 28;14(13):3167. doi: 10.3390/cancers14133167. PMID: 35804943

miR-99a-5p modulates doxorubicin resistance via the COX-2/ABCG2 axis in triple-negative breast cancer: from the discovery to in vivo studies. Garrido-Cano I, Adam-Artigues A, Lameirinhas A, Blandez J, Candela-Noguera V, Rojo F, Zazo S, Madoz-Gurpide J, Lluch A, Bermejo B, Sancenon F, Cejalvo J, Martinez-Manez R, Eroles P. Cancer Communications. 2022 Dec;42(12):1412-1416. doi: 10.1002/cac2.12352. PMID: 35997029

mTOR inhibition and trastuzumab-emtansine (T-DM1) in HER2-positive breast cancer. Casadevall D, Hernandez-Prat A, Garc A-Alonso S, Arpi-Llucia O, Menendez S, Qin M, Guardia C, Morancho B, Sanchez-Mart N F, Zazo S, Gavilan E, Sabbaghi M, Eroles P, Cejalvo J, Lluch A, Rojo F, Pandiella A, Rovira A, Albanell J. Molecular Cancer Research. 2022 Jul 6;20(7):1108-1121. doi: 10.1158/1541-7786.MCR-21-0545. PMID: 35348729

Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A. Mouron S, Bueno MJ, Lluch A, Manso L, Calvo I, Cortes J, Garcia-Saenz JA, Gil-Gil M, Martinez-Janez N, Apala JV, Caleiras E, Ximénez-Embún P, Muñoz J, Gonzalez-Cortijo L, Murillo R, Sánchez-Bayona R, Cejalvo JM, Gómez-López G, Fustero-Torre C, Sabroso-Lasa S, Malats N, Martinez M, Moreno A, Megias D, Malumbres M, Colomer R, Quintela-Fandino M. Nature Communications. 2022 Dec 7;13(1):7529. doi: 10.1038/s41467-022-35065-z. PMID: 36477027

Targeting HER2-AXL heterodimerization to overcome resistance to HER2 blockade in breast cancer. Adam-Artigues A, Arenas E, Martinez-Sabadell A, Braso-Maristany F, Cervera R, Tormo E, Hernando C, Martinez M, Carbonell-Asins J, Simon S, Poveda J, Moragon S, Zazo S, Martinez D, Rovira A, Burgues O, Rojo F, Albanell J, Bermejo B, Lluch A, Prat A, Arribas J, Eroles P, Cejalvo J. Science Advances. 2022 May 20;8(20):eabk2746. doi: 10.1126/sciadv.abk2746. PMID: 35594351

The value of sentinel lymph-node biopsy after neoadjuvant therapy: an overview. Vazquez J, Pinero A, de Castro F, Lluch A, Martin M, Barnadas A, Alba E, Rodriguez-Lescure A, Rojo F, Gimenez J, Sola I, Quintana M, Bonfill X, Urrutia G, Sanchez-Rovira P. Clinical & Translational Oncology. 2022 Sep;24(9):1744-1754. doi: 10.1007/s12094-022-02824-9. PMID: 35414152

Circadian PERformance in breast cancer: a germline and somatic genetic study of PER3VNTR polymorphisms and gene co-expression. Fores-Martos J, Cervera-Vidal R, Sierra-Roca J, Lozano-Asencio C, Fedele V, Cornelissen S, Edvarsen H, Tadeo-Cervera I, Eroles P, Lluch A, Tabares-Seisdedos R, Falco A, Van’t Veer LJ, Schmidt M, Quigley DA, Borresen-Dale AL, Kristensen VN, Balmain A, Climent J. NPJ Breast Cancer. 2021 Sep 10;7(1):118. doi: 10.1038/s41523-021-00329-2. PMID: 34508103

Circulating miR-30b-5p levels in plasma as a novel potential biomarker for early detection of breast cancer. Adam-Artigues A, Garrido-Cano I, Simon S, Ortega B, Moragon S, Lameirinhas A, Constancio V, Salta S, Burgues O, Bermejo B, Henrique R, Lluch A, Jeronimo C, Eroles P, Cejalvo J. ESMO Open. 2021 Jan 18;6(1):100039. doi: 10.1016/j.esmoop.2020.100039. PMID: 33477007

Fertility and breast cancer: a literature review of counseling, preservation options and outcomes. Moragon S, Di Liello R, Bermejo B, Hernando C, Olcina E, Chirivella I, Lluch A, Cejalvo JM, Martinez MT, Critical Reviews In Oncology/Hematology. 2021 Aug 27;166:103461. doi: 10.1016/j.critrevonc.2021.103461. PMID: 34461268

Nanoporous Anodic Alumina-Based Sensor for miR-99a-5p Detection as an Effective Early Breast Cancer Diagnostic Tool. Garrido-Cano I, Pla L, Santiago-Felipe S, Simon S, Ortega B, Bermejo B, Lluch A, Cejalvo J, Eroles P, Martinez-Manez R. ACS Sensors. 2021 Mar 26;6(3):1022-1029. doi: 10.1021/acssensors.0c02222. PMID: 33599490

Oral Selective Estrogen Receptor Degraders (SERDs) as a novel breast cancer therapy: present and future from a clinical perspective. Hernando C, Ortega-Morillo B, Tapia M, Moragon S, Martinez M, Eroles P, Garrido-Cano I, Adam-Artigues A, Lluch A, Bermejo B, Cejalvo J. International Journal of Molecular Sciences. 2021 Jul 22;22(15):7812. doi: 10.3390/ijms22157812. PMID: 34360578

Preclinical and clinical characterization of fibroblast-derived neuregulin-1 on trastuzumab and pertuzumab activity in HER2-positive breast cancer. Guardia C, Bianchini G, Arpi-LLucia O, Menendez S, Casadevall D, Galbardi B, Dugo M, Servitja S, Montero J, Soria-Jimenez L, Sabbaghi M, Pena R, Madoz-Gurpide J, Lloveras B, Lluch A, Eroles P, Arribas J, Pandiella A, Gianni L, Rojo F, Rovira A, Albanell J. Clinical Cancer Research. 2021 Sep 15;27(18):5096-5108. doi: 10.1158/1078-0432.CCR-20-2915. PMID:34385295

Selective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positive metastatic breast cancer. Smyth LM, Batist G, Meric-Bernstam F, Kabos P, Spanggaard I, Lluch A, Jhaveri K, Varga A, Wong A, Schram AM, Ambrose H, Carr TH, de Bruin EC, Salinas-Souza C, Foxley A, Hauser J, Lindemann JPO, Maudsley R, McEwen R, Moschetta M, Nikolaou M, Schiavon G, Razavi P, Banerji U, Baselga J, Hyman DM, Chandarlapaty S. NPJ Breast Cancer. 2021 Apr 16;7(1):44. doi: 10.1038/s41523-021-00251-7. PMID: 33863913

Ten-year assessment of a cancer fast-track programme to connect primary care with oncology: reducing time from initial symptoms to diagnosis and treatment initiation. Martinez MT, Monton-Bueno J, Simon S, Ortega B, Moragon S, Rosello S, Insa A, Navarro J, Sanmartin A, Julve A, Buch E, Pena A, Franco J, Martinez-Jabaloyas J, Marco J, Forner MJ, Cano A, Silvestre A, Teruel A, Lluch A, Cervantes A, Chirivella Gonzalez I. ESMO open. 2021 May 11;6(3):100148. doi: 10.1016/j.esmoop.2021.100148. PMID: 33989988

Projects
Reference: CB16/12/00481
Title: CIBER Cáncer de mama
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Ana Lluch Hernández, Emilio Alba Conejo
Duration: 2017 – 2021
Total budget:
+ Info
Title: Overcoming resistance to HER2 blockade in breast cancer: AXL as a promising druggable target and prognostic biomarker
Doctoral candidate: Adam Artigues, Anna
Director(s): Lluch Hernández, Ana; Eroles Asensio, Pilar
Date of the defense: 12/04/2022
University: Universitat de València

Title: Estudio de las alteraciones genéticas asociadas con la resistencia al tratamiento neoadyuvante de deprivación estrogénica en cáncer de mama
Doctoral candidate: Guerrero Zotano, Ángel Luis
Director(s): López Guerrero, José Antonio; Guillem Porta, Vicente; Lluch Hernández, Ana
Date of the defense: 21/01/2021
University: Universitat de València

Title: Implicaciones del MAMMI-PET en el diagnóstico y tratamiento del cáncer de mama. Comparación con los resultados anatomopatológicos y con otras pruebas de imagen
Doctoral candidate: De Andrés Gómez, Alejandra
Director(s): Fuster Diana, Carlos Alberto; Villalba Ferrer, Francisco Leopoldo; Lluch Hernández, Ana
Date of the defense: 16/10/2020
University: Universitat de València

Title: Epigenetic regulation of resistance to treatments in triple negative and HER2+ breast cancer: mirnas involved
Doctoral candidate: Cabello Navarro, Paula
Director(s): Erolés Asensio, Pilar; Lluch Hernández, Ana
Date of the defense: 28/09/2020
University: Universitat Politècnica de València

Title: Evaluación de los cambios en la respuesta linfocitaria en el microambiente tumoral como factor pronóstico y predictivo de respuesta a la quimioterapia neoadyuvante del cáncer de mama triple negativo estadio ii-iii
Doctoral candidate: Herrero Vicent, Carmen
Director(s): Ruiz Simón, Amparo; Calatrava Fons, Ana; Guillem Porta, Vicente; Lluch Hernández, Ana
Date of the defense: 27/05/2019
University: Universitat de València

Title: Identificación de biomarcadores circulantes con valor pronóstico y predictivo de respuesta en cáncer de mama triple negativo
Doctoral candidate: Salvador Coloma, Carmen
Director(s): Lluch Hernández, Ana; Santaballa Bertrán, Ana María; Font de Mora Sainz, Jaime
Date of the defense: 10/05/2019
University: Universitat de València

Title: Identificación de los factores clínico-patológicos relacionados con la obtención de la respuesta completa patológica en pacientes con cáncer de mama tratadas con quimioterapia neoadyuvante. Validación del residual cancer burden (rcb) como factor pronóstico
Doctoral candidate: Pons Sanz, Vanesa
Director(s): Lluch Hernández, Ana; Pérez Fidalgo, Jose Alejandro; Burgués Gasión, Octavio
Date of the defense: 02/04/2019
University: Universitat de València

Title: Study of the epi-/genomic dysregulation of breast cancer in women under 35 years and evaluation of cellular models
Doctoral candidate: Oltra Sanchis, Sara
Director(s): Ribas Despuig, Gloria; Lluch Hernández, Ana
Date of the defense: 18/01/2019
University: Universitat de València