Grupo de Investigación en Enfermedades Respiratorias

Área de Metabolismo y Daño Orgánico

Estudio de complicaciones respiratorias en pacientes con enfermedades neuromusculares. Utilidad de ventilación mecánica y otros soportes respiratorios

Implicación del diagnóstico precoz de las enfermedades obstructivas de las vías respiratorias en el pronóstico y seguimiento de los pacientes. Programa de detección temprana de enfisema. Programa de detección precoz de la deficiencia de alfa 1 antitripsina

Programa de seguimiento precoz de la EPOC con fenotipo agudizador

Programa de control del asma grave

Control de trastornos respiratorios durante el sueño como prevención de factores de riesgo cardiovascular

Diagnóstico precoz de enfermedades respiratorias intersticiales idiopáticas (FPI) y enfermedades secundarias (toxicidad por fármacos y post-TMO)

Caracterización clínica y genética de la neumonía adquirida en la comunidad

Coordinador
Dr. Jaime Signes-Costa Miñana
jaimesignescosta@gmail.com

INVESTIGADORES
R4 Senior

Jaime Signes-Costa Miñana    

R3 Consolidado

Jesús Sancho Chinesta
José Franco Serrano
Mª Cruz González Villaescusa
Mª Luisa Briones Urtiaga

R2 Novel / Emergente

Carmen Muñoz Esteban
Francisco Carrión Valero
José Luis Díaz Cordobés
Mª Belén Safont Muñoz
Pilar Bañuls Polo

R1 Predoctoral

Elvira Bondía Real
Irene Bocigas Huéscar
Nieves Navarro Soriano
Paola Lisseth Ordóñez Gómez
Santos Ferrer Espinosa

STAFF
Colaborador/a

Alba Mulet Arabi
Alejandro Ochoa Alvarado
Ana Ferrer Pons
Andrea Ballester Férriz
Antonio Quezada Reynosa
Cristina Rosario Martín
Enric Burés Sales
Erick Monclou Garzón
Heidi Mora Bastida
Lucía Fernández Presa
Manuela Marín González
Mariam García Alfaro
Natividad Blasco Angulo
Pablo Royo Simó

Enfermero/a
Técnico/a
Apoyo
Publicaciones
Adaptive immune responses to SARS-CoV-2 in recovered severe COVID-19 patients. Olea B, Albert E, Torres I, Amat P, Remigia M, Gozalbo-Rovira R, Rodriguez-Diaz J, Buesa J, Blasco M, Redon J, Signes-Costa J, Navarro D. Journal of Clinical Virology. 2021 Sep;142:104943. doi: 10.1016/j.jcv.2021.104943. PMID: 34391981

Clinical profile and predictors of in-hospital mortality among older patients admitted for COVID-19. Becerra-Munoz V, Nunez-Gil I, Eid C, Aguado M, Romero R, Huang J, Mulet Arabi A, Ugo F, Rametta F, Liebetrau C, Aparisi A, Fernandez-Rozas I, Viana-Llamas M, Feltes G, Pepe M, Moreno-Rondon L, Cerrato E, Raposeiras-Roubin S, Alfonso E, Carrero-Fernandez A, Buzon-Martin L, Abumayyaleh M, Gonzalez A, Ortiz A, Macaya C, Estrada V, Fernandez-Perez C, Gomez-Doblas J. Age and Ageing. 2021 Feb 26;50(2):326-334. doi: 10.1093/ageing/afaa258. PMID: 33201181

COVID-19 and the impact of arterial hypertension-An analysis of the international HOPE COVID-19 Registry (Italy-Spain-Germany). El-Battrawy I, Nunez-Gil I, Abumayyaleh M, Estrada V, Becerra-Munoz V, Uribarri A, Fernandez-Rozas I, Feltes G, Arroyo-Espliguero R, Trabattoni D, Lopez-Pais J, Pepe M, Romero R, Castro-Mejia A, Cerrato E, Astrua T, D’Ascenzo F, Fabregat-Andres O, Signes-Costa J, Marin F, Buonsenso D, Bardaji A, Tellez M, Fernandez-Ortiz A, Macaya C, Akin I. European Journal of Clinical Investigation. 2021 Aug 19;e13582. doi: 10.1111/eci.13582. PMID: 34409593

COVID-19 and Tobacco. Rabade Castedo C, Signes-Costa J, Jimenez-Ruiz C. Archivos de Bronconeumologia. 2021 Jan;57 Suppl 1:5-6. doi: 10.1016/j.arbres.2020.07.014. PMID: 32917432

Does there exist an obesity paradox in COVID-19? Insights of the international HOPE-COVID-19-registry. Abumayyaleh M, Nunez Gil I, El-Battrawy I, Estrada V, Becerra-Munoz V, Aparisi A, Fernandez-Rozas I, Feltes G, Arroyo-Espliguero R, Trabattoni D, Lopez-Pais J, Pepe M, Romero R, Garcia D, Biole C, Astrua T, Eid C, Alfonso E, Fernandez-Presa L, Espejo C, Buonsenso D, Raposeiras S, Fernandez C, Macaya C, Akin I, HOPE COVID-19 investigators. Obesity Research & Clinical Practice. 2021 Mar 3;S1871-403X(21)00034-X. doi: 10.1016/j.orcp.2021.02.008. PMID: 33741308

Effect of one-year dextromethorphan/quinidine treatment on management of respiratory impairment in amyotrophic lateral sclerosis. Sancho J, Ferrer S, Bures E, Diaz JL, Torrecilla T, Signes-Costa J, Servera E. Respiratory Medicine. 2021 Jul 7;186:106536. doi: 10.1016/j.rmed.2021.106536. PMID: 34260979

Gender differences in the presentation and outcomes of hospitalized patients with COVID-19. Biole C, Bianco M, Nunez-Gil IJ, Cerrato E, Spirito A, Raposeiras Roubin S, Viana-Llamas MC, Gonzalez A, Castro-Mejia AF, Maroun Eid C, Fernandez-Perez C, Uribarri A, Alfonso-Rodriguez E, Ugo F, Guerra F, Feltes G, Akin I, Fernandez-Rozas I, Blasco-Angulo N, Huang J, Garcia Aguado M, Pepe M, Romero R, Becerra-Munoz VM, Estrada V, Macaya C. Journal of Hospital Medicine. 2021 Jun;16(6):349-352. doi: 10.12788/jhm.3594. PMID: 34129486

Las unidades de deshabituacion tabaquica como oportunidad para el diagnostico de EPOC: el proyecto 1000-200. Lopez-Campos JL, Jimenez-Ruiz CA, Meneses Petersen ED, Rabade Castedo C, Asensio Sanchez S, Vaquero Lozano P, Ferrer Espinosa S, Perez Soriano MP, de Higes Martinez E, Garcia de Llanos C, Pastor Espla E, Cabrera Cesar E, Mogrovejo S, Riesco Miranda JA, Barrueco Ferrero M, Callejas Gonzalez FJ, Sandoval Contreras R, Pena Miguel T, Peris Cardells R, Gonzalez Dou MV, Guzman Aguilar JM, Amado CA, Gorordo Unzueta MI, Rois Seijas P, Martinez Muniz MA, Naval Sendra E, Granda-Orive JI, Signes-Costa J. Archivos de Bronconeumologia. 2021 Jun 1;S0300-2896(21)00169-1. doi: 10.1016/j.arbres.2021.05.013. PMID: 34158184

Mechanical Insufflation-Exsufflation With Oscillations in Amyotrophic Lateral Sclerosis With Home Ventilation via Tracheostomy. Sancho Chinesta J, Bures Sales E, Ferrer Espinosa S, Lahosa Córdoba C, Signes-Costa Miñana J, Servera Pieras E. Respiratory Care. 2021 Mar;66(3):378-383. doi: 10.4187/respcare.08145. PMID: 33082217

Mouthpiece ventilation in neuromuscular disorders: Narrative review of technical issues important for clinical success. Toussaint M, Chatwin M, Goncalves M, Gonzalez-Bermejo J, Benditt J, McKim D, Sancho J, Hov B, Sansone V, Prigent H, Carlucci A, Wijkstra P, Garabelli B, Escarrabill J, Pinto T, Audag N, Verweij-van den Oudenrijn L, Ogna A, Hughes W, Devaux C, Chaulet J, Andersen T, ENMC Respiratory Therapy Consortium, ENMC Respiratory Therapy Consortium. Respiratory medicine. 2021 Mar 24;180:106373. doi: 10.1016/j.rmed.2021.106373. PMID: 33798870

Portopulmonary hypertension: prognosis and management in the current treatment era. Results from the REHAP Registry. Lazaro Salvador M, Quezada Loaiza C, Rodriguez Padial L, Barbera J, Lopez-Meseguer M, Lopez-Reyes R, Sala Llinas E, Alcolea S, Blanco I, Escribano Subias P, Marin Gonzalez M, REHAP investigators. Internal Medicine Journal. 2021 Mar;51(3):355-365. doi: 10.1111/imj.14751. PMID: 31943676

Prevalence and 30-Day Mortality in Hospitalized Patients With Covid-19 and Prior Lung Diseases. Signes-Costa J, Nunez-Gil I, Soriano J, Arroyo-Espliguero R, Eid C, Romero R, Uribarri A, Fernandez-Rozas I, Aguado M, Becerra-Munoz V, Huang J, Pepe M, Cerrato E, Raposeiras S, Gonzalez A, Franco-Leon F, Wang L, Alfonso E, Ugo F, Garcia-Prieto J, Feltes G, Abumayyaleh M, Espejo-Paeres C, Jativa J, Masjuan A, Macaya C, Carbonell Asins J, Estrada V, HOPE COVID-19 investigators. Archivos de Bronconeumologia. 2021 Apr;57 Suppl 2:13-20. doi: 10.1016/j.arbres.2020.11.012. PMID: 33423874

Renin-angiotensin system inhibitors effect before and during hospitalization in COVID-19 outcomes: Final analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID-19) registry. Nunez-Gil IJ, Olier I, Feltes G, Viana-Llamas MC, Maroun-Eid C, Romero R, Fernandez-Rozas I, Uribarri A, Becerra-Munoz VM, Alfonso-Rodriguez E, Garcia-Aguado M, Elola J, Castro-Mejia A, Pepe M, Garcia-Prieto JF, Gonzalez A, Ugo F, Cerrato E, Bondia E, Raposeiras-Roubin S, Mendez JL, Espejo C, Lopez-Masjuan A, Marin F, Lopez-Pais J, Abumayyaleh M, Corbi-Pascual M, Liebetrau C, Ramakrishna H, Estrada V, Macaya C, Fernandez-Ortiz A. American Heart Journal. 2021 Jul;237:104-115. doi: 10.1016/j.ahj.2021.04.001. PMID: 33845032

SARS-CoV-2-reactive interferon-gamma-producing CD8+ T cells in patients hospitalized with Coronavirus Disease 2019. Gimenez Quiles E, Albert Vicent E, Torres Fink I, Remigia Pellicer M, Alcaráz Soriana M, Galindo Puerto M, Blasco Cortes M, Solano Vercet C, Forner Giner M, Redón Mas J, Signes-Costa Miñana J, Navarro Ortega D. Journal of Medical Virology. 2021 Jan;93(1):375-382. doi: 10.1002/jmv.26213. PMID: 32579268

Ten-year assessment of a cancer fast-track programme to connect primary care with oncology: reducing time from initial symptoms to diagnosis and treatment initiation. Martinez MT, Monton-Bueno J, Simon S, Ortega B, Moragon S, Rosello S, Insa A, Navarro J, Sanmartin A, Julve A, Buch E, Pena A, Franco J, Martinez-Jabaloyas J, Marco J, Forner MJ, Cano A, Silvestre A, Teruel A, Lluch A, Cervantes A, Chirivella Gonzalez I. ESMO open. 2021 May 11;6(3):100148. doi: 10.1016/j.esmoop.2021.100148. PMID: 33989988

Tracheostomy in patients with COVID-19: predictors and clinical features. Sancho J, Ferrer S, Lahosa C, Posadas T, Bures E, Banuls P, Fernandez-Presa L, Royo P, Blasco M, Signes-Costa J. European Archives of Oto-Rhino-Laryngology. 2021 Jan 1;1-9. doi: 10.1007/s00405-020-06555-x. PMID: 33386436

Underlying heart diseases and acute COVID-19 outcomes. Abraham W, Lindenfeld J, Ponikowski P, Agostoni P, Butler J, Desai A, Filippatos G, Gniot J, Fu M, Gullestad L, Howlett J, Nicholls S, Redon J, Schenkenberger I, Silva-Cardoso J, Stork S, Krzysztof Wranicz J, Savarese G, Brueckmann M, Jamal W, Nordaby M, Peil B, Ritter I, Ustyugova A, Zeller C, Salsali A, Anker S. EUROPEAN HEART JOURNAL. 2021;28(2):202-214. doi: 10.5603/CJ.a2020.0183. PMID: 33346365

252nd ENMC international workshop: Developing best practice guidelines for management of mouthpiece ventilation in neuromuscular disorders. March 6th to 8th 2020, Amsterdam, the Netherlands. Chatwin M, Gonçalves M, Gonzalez-Bermejo J, Toussaint M, ENMC Respiratory Therapy Consortium. Neuromuscular disorders. 2020 Sep;30(9):772-781. doi: 10.1016/j.nmd.2020.07.008. PMID: 32859499

Association between a comprehensive smoking ban and hospitalization for acute myocardial infarction: An observational study in the Autonomous Community of Valencia, Spain. Carrión Valero F, Quiles-Izquierdo J, Gonzalez-Monte C, Taberner Alberola F, Lluch Rodrigo J, Chorro Gascó F, Martín Moreno J. Revista Portuguesa de Cardiología. 2020 Feb;39(2):77-84. doi: 10.1016/j.repc.2019.04.009. PMID: 32291119

Co-detection of respiratory pathogens in patients hospitalized with Coronavirus viral disease-2019 pneumonia. Blasco Cortes M, Buesa Gomez J, Colomina Rodríguez F, Forner Giner M, Galindo Puerto M, Navarro Perez J, Noceda Bermejo J, Redón Mas J, Signes-Costa Miñana J, Navarro Ortega D. Journal Of Medical Virology. 2020 Oct;92(10):1799-1801. doi: 10.1002/jmv.25922. PMID: 32320082

COPD at the end of life: predictors of the emotional distress of patients and their family caregivers. Soto-Rubio A, Valero Moreno S, Diaz Cordobes J, Andreu Y, Perez Marin M. PLoS One. 2020 Oct 16;15(10):e0240821. doi: 10.1371/journal.pone.0240821. PMID: 33064747

Cost-benefit analysis of funding smoking cessation before surgery. Jimenez-Ruiz C, Martin V, Alsina-Restoy X, Granda-Orive J, Higes-Martinez E, Garcia-Rueda M, Genoves-Crespo M, Lopez-Garcia C, Lorza-Blasco J, Marquez F, Ramos-Pinedo A, Riesco-Miranda J, Signes-Costa Miñana J, Solano-Reina S, Vaquero-Lozano P, Rejas J. British Journal of Surgery. 2020 Jul;107(8):978-994. doi: 10.1002/bjs.11506. PMID: 32372474

COVID-19: New disease, new manifestations. Tarrasó Castillo J, Posadas Blazquez V, Lahosa Córdoba C, Signes-Costa Miñana J. Archivos de Bronconeumologia. 2020 Dec;56(12):825-826. doi: 10.1016/j.arbres.2020.07.007. PMID: 32843200

Early and Late Cardiovascular Events in Patients Hospitalized for Community-Acquired Pneumonia. Aldás I, Menéndez R, Méndez R, España PP, Almirall J, Boderías L, Rajas O, Zalacaín R, Vendrell M, Mir I, Torres A, grupo NEUMONAC. Archivos de Bronconeumología. 2020 Sep;56(9):551-558. doi: 10.1016/j.arbres.2019.10.009. PMID: 31791646

Funding smoking cessation therapy: When can we expect it?. Signes-Costa Miñana J, Garcia Rueda M, Jimenez-Ruiz C. Archivos de Bronconeumologia. 2020 May;56(5):273-274. doi: 10.1016/j.arbres.2019.08.003. PMID: 31668771

Gene Therapy in Rare Respiratory Diseases: What Have We Learned So Far?. Bañuls Soto L, Pellicer Roig D, Castillo Corullon S, Navarro García M, Magallón Serrano M, González C, Dasí Fernández F. Journal of Clinical Medicine. 2020 Aug 8;9(8):2577. doi: 10.3390/jcm9082577. PMID: 32784514

Impact of the 2005 and 2010 Spanish smoking laws on hospital admissions for tobacco-related diseases in Valencia, Spain. Carrión Valero F, Quiles-Izquierdo J, Gonzalez-Monte C, Taberner Alberola F, Lluch-Rodrigo J, Chorro Gascó F, Martín Moreno J. Public Health. 2020 Mar;180:29-37. doi: 10.1016/j.puhe.2019.10.016. PMID: 31838343

Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry. Nunez-Gil I, Fernandez-Perez C, Estrada V, Becerra-Munoz V, El-Battrawy I, Uribarri A, Fernandez-Rozas I, Feltes G, Viana-Llamas M, Trabattoni D, Lopez-Pais J, Pepe M, Romero R, Castro-Mejia A, Cerrato E, Astrua T, D’Ascenzo F, Fabregat-Andres O, Moreu J, Guerra F, Signes-Costa Miñana J, Marin F, Buosenso D, Bardaji A, Raposeiras-Roubin S, Elola J, Molino A, Gomez-Doblas J, Abumayyaleh M, Aparisi A, Molina M, Guerri A, Arroyo-Espliguero R, Assanelli E, Mapelli M, Garcia-Acuna J, Brindicci G, Manzone E, Ortega-Armas M, Bianco M, Trung C, Nunez M, Castellanos-Lluch C, Garcia-Vazquez E, Cabello-Clotet N, Jamhour-Chelh K, Tellez M, Fernandez-Ortiz A, Macaya C, HOPE COVID-19 Investigators. Internal and Emergency Medicine. 2020 Nov 9;1-10. doi: 10.1007/s11739-020-02543-5. PMID: 33165755

Prognostic Impact of Hyponatremia and Hypernatremia in COVID-19 Pneumonia. A HOPE-COVID-19 (Health Outcome Predictive Evaluation for COVID-19) Registry Analysis. Ruiz-Sanchez J, Nunez-Gil I, Cuesta M, Rubio M, Maroun-Eid C, Arroyo-Espliguero R, Romero R, Becerra-Munoz V, Uribarri A, Feltes G, Trabattoni D, Molina M, Garcia Aguado M, Pepe M, Cerrato E, Alfonso E, Castro Mejia A, Roubin S, Buzon L, Bondia E, Marin F, Lopez Pais J, Abumayyaleh M, D’Ascenzo F, Rondano E, Huang J, Fernandez-Perez C, Macaya C, de Miguel Novoa P, Calle-Pascual A, Estrada Perez V, Runkle I, HOPE COVID-19 investigators. Frontiers in Endocrinology. 2020 Nov 30;11:599255. doi: 10.3389/fendo.2020.599255. PMID: 33329400

Respiratory support in COPD patients after acute exacerbation with monitoring the quality of support (Rescue2-monitor): an open-label, prospective randomized, controlled, superiority clinical trial comparing hospital- versus home-based acute non-invasive ventilation for patients with hypercapnic chronic obstructive pulmonary disease. Rescue2-monitor group. Trials. 2020 Oct 22;21(1):877. doi: 10.1186/s13063-020-04672-w. PMID: 33092618

SARS-CoV-2 antibodies, serum inflammatory biomarkers and clinical severity of hospitalized COVID-19 patients. Gozalbo-Rovira R, Gimenez Quiles E, Latorre V, Frances-Gomez C, Albert Vicent E, Buesa Gomez J, Marina A, Blasco Cortes M, Signes-Costa Miñana J, Rodriguez Diaz J, Geller R, Navarro Ortega D. Journal of Clinical Virology. 2020 Oct;131:104611. doi: 10.1016/j.jcv.2020.104611. PMID: 32882666

Should MASP-2 Deficiency Be Considered a Primary Immunodeficiency? Relevance of the Lectin Pathway. Garcia-Laorden M, Hernandez-Brito E, Munoz-Almagro C, Pavlovic-Nesic S, Rua-Figueroa I, Briones Urtiaga M, Rajas O, Borderias L, Payeras A, Lorente L, Freixinet J, Ferreres Franco J, Obando I, Gonzalez-Quevedo N, de Castro F, Sole-Violan J, Rodriguez-Gallego C. Journal of Clinical Immunology. 2020 Jan;40(1):203-210. doi: 10.1007/s10875-019-00714-4. PMID: 31828694

Similar Clinical Course and Significance of Circulating Innate and Adaptive Immune Cell Counts in STEMI and COVID-19. de Dios E, Rios-Navarro C, Perez-Sole N, Gavara J, Marcos-Garces V, Rodríguez E, Carratalá A, Forner MJ, Navarro J, Blasco ML, Bondia E, Signes-Costa J, Vila JM, Forteza MJ, Chorro 1MJ, Bodi V. Journal of Clinical Medicine. 2020 Oct 28;9(11):E3484. doi: 10.3390/jcm9113484. PMID: 33126723

The domestic environment and the lung mycobiome. Rubio-Portillo E, Orts D, Llorca E, Fernández C, Antón J, Ferrer C, Gálvez B, Esteban V, Revelles E, Pérez-Martín C, Gómez-Imbernón E, Adsuar J, Piqueras P, Amat B, Franco J, Colom MF. Microorganisms. 2020 Nov 2;8(11):1717. doi: 10.3390/microorganisms8111717. PMID: 33147738

Usefulness of Oscillations Added to Mechanical In-Exsufflation in Amyotrophic Lateral Sclerosis. Sancho Chinesta J, Bures Sales E, Ferrer Espinosa S, Bondia Real E, Servera Pieras E. Respiratory Care. 2020 May;65(5):596-602. doi: 10.4187/respcare.07202. PMID: 31719190

Demographic and clinical profile of idiopathic pulmonary fibrosis patients in Spain: the SEPAR National Registry. Fernández-Fabrellas E, Molina-Molina M, Soriano JB, Portal JAR, Ancochea J, Valenzuela C, Xaubet A; SEPAR-IPF National Registry. Respiratory Research. 2019 Jun 17;20(1):127. doi: 10.1186/s12931-019-1084-0. PMID: 31208406

Official Statement of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) on Electronic Cigarettes and IQOS. Signes-Costa J, de Granda-Orive JI, Ramos Pinedo Á, Camarasa Escrig A, de Higes Martínez E, Rábade Castedo C, Cabrera César E, Jiménez-Ruiz CA. Archivos de Bronconeumologia. 2019 Nov;55(11):581-586. doi: 10.1016/j.arbres.2019.04.023. PMID: 31235270

Relationship Between Cognitive-Behavioral Impairment and Clinical and Functional Parameters in ALS and Reliability of the Edinburgh Cognitive and Behavioural ALS Screen to Assess ALS: Preliminary Findings. Díaz JL, Mondragón H, Sancho J, Aguilar EJ, Servera E. Cognitive and Behavioral Neurology. 2019 Sep;32(3):185-192. doi: 10.1097/WNN.0000000000000199. PMID: 31517702

Tracheotomy in Amyotrophic Lateral Sclerosis: The Argument in Favor. Servera E, Sancho J, Ferrer S. Archivos de Bronconeumologia. 2019 Jul;55(7):347-348. doi: 10.1016/j.arbres.2018.11.007. PMID: 30971363

Proyectos
Referencia: COV20/01209
Título: Cambios en los test de función pulmonar en pacientes con neumonia por CoVid19
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Jaime Signes-Costa
Duración: 2020 – 2021
Presupuesto: 73.500 €

+ Información
252nd ENMC international workshop: Developing best practice guidelines for management of mouthpiece ventilation in neuromuscular disorders. March 6th to 8th 2020, Amsterdam, the Netherlands. Chatwin M, Gonçalves M, Gonzalez-Bermejo J, Toussaint M, ENMC Respiratory Therapy Consortium. Neuromuscular disorders. 2020 Sep;30(9):772-781. doi: 10.1016/j.nmd.2020.07.008. PMID: 32859499

Título: Prevención del tabaquismo en alumnos de educación secundaria obligatoria. Modelo de intervención multipersonal sobre alumnos, profesores y padres
Doctorando: Ribera I Osca, Joan Antoni
Director: Martín Moreno, José María; Carrión Valero, Francisco
Fecha: 17/02/2020
Universidad: Universitat de València