Chronic pregabalin treatment ameliorates pain, but not depressive-like behaviors, in a reserpine-induced myalgia model in rats. Gonzalez-Soler E, Blasco-Serra A, Alfosea-Cuadrado G, Igual-Lopez M, Orduña Valls J, Tornero Tornero C, Valverde-Navarro A. Pain Physician. 2020 Nov;23(6):E581-E590. PMID: 33185377

Could lung bacterial dysbiosis predict ICU mortality in patients with extra-pulmonary sepsis? A proof-of-concept study. Sepsis Lung Microbiome Study Group. Intensive Care Medicine. 2020 Nov;46(11):2118-2120. doi: 10.1007/s00134-020-06190-4. PMID: 32767076

Decompressive craniectomy improves qtc interval in traumatic brain injury patients. Dabrowski W, Siwicka-Gieroba D, Robba C, Badenes Quiles R, Kotfis K, Schlegel T, Jaroszynski A. International Journal of Environmental Research and Public Health. 2020 Nov 21;17(22):8653. doi: 10.3390/ijerph17228653. PMID: 33233364

Delays in hospital admissions in patients with fractures across 18 low-income and middle-income countries (INORMUS): a prospective observational study. Pouramin P, Li C, Busse J, Sprague S, Devereaux P, Jagnoor J, Ivers R, Bhandari M, Aguilar Aguilar G, INORMUS Investigators. Lancet Global Health. 2020 May;8(5):e711-e720. doi: 10.1016/S2214-109X(20)30067-X. PMID: 32353318

Determination of brain death/death by neurologic criteria: The World Brain Death Project. Greer D, Shemie S, Lewis A, Torrance S, Varelas P, Goldenberg F, Bernat J, Souter M, Topcuoglu M, Alexandrov A, Baldisseri M, Bleck T, Citerio G, Dawson R, Hoppe A, Jacobe S, Manara A, Nakagawa T, Pope T, Silvester W, Thomson D, Al Rahma H, Badenes Quiles R, Baker A, Cerny V, Chang C, Chang T, Gnedovskaya E, Han M, Honeybul S, Jimenez E, Kuroda Y, Liu G, Mallick U, Marquevich V, Mejia-Mantilla J, Piradov M, Quayyum S, Shrestha G, Su Y, Timmons S, Teitelbaum J, Videtta W, Zirpe K, Sung G. JAMA-Journal of the American Medical Association. 2020 Sep 15;324(11):1078-1097. doi: 10.1001/jama.2020.11586. PMID: 32761206

Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial. Villar J, Ferrando C, Martinez D, Ambros A, Munoz T, Soler J, Aguilar Aguilar G, Alba F, Gonzalez-Higueras E, Conesa L, Martin-Rodriguez C, Diaz-Dominguez F, Serna-Grande P, Rivas R, Ferreres Franco J, Belda Nacher F, Capilla L, Tallet A, Anon J, Fernandez R, Gonzalez-Martin J, Dexamethasone ARDS Network. Lancet Respiratory Medicine. 2020 Mar;8(3):267-276. doi: 10.1016/S2213-2600(19)30417-5. PMID: 32043986

Early adjustment of empirical antibiotic therapy of bloodstream infections on the basis of direct identification of bacteria by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and Gram staining results. Torres Fink I, Pinto Plá C, Oltra Sempere R, Pascual Martín T, Carbonell Monleon N, Colomina Rodríguez F, Tormo Diaz M, Albert Vicent E, Aguilar Aguilar G, Solano Vercet C, Navarro Ortega D. Journal of Infection and Chemotherapy. 2020 Sep;26(9):963-969. doi: 10.1016/j.jiac.2020.04.019. PMID: 32386929

Early Osmotherapy in Severe Traumatic Brain Injury: An International Multicenter Study. Anstey J, Taccone F, Udy A, Citerio G, Duranteau J, Ichai C, Badenes Quiles R, Prowle J, Ercole A, Oddo M, Schneider A, van der Jagt M, Wolf S, Helbok R, Nelson D, Skrifvars M, Harrois A, Presneill J, Cooper D, Bailey M, Bellomo R, TBI Collaborative. Journal of Neurotrauma. 2020 Jan 1;37(1):178-184. doi: 10.1089/neu.2019.6399. PMID: 31286839

Effects of age and sex on optic nerve sheath diameter in healthy volunteers and patients with traumatic brain injury. Cardim D, Czosnyka M, Chandrapatham K, Badenes Quiles R, Bertuccio A, Di Noto A, Donnelly J, Pelosi P, Ball L, Hutchinson P, Robba C. Frontiers in Neurology. 2020 Aug 7;11:764. doi: 10.3389/fneur.2020.00764. PMID: 32849220

Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy: a randomised controlled trial. Ferrando C, Aldecoa C, Unzueta C, et al. British Journal of Anaesthesia. 2020 Jan;124(1):110-120. doi: 10.1016/j.bja.2019.10.009. PMID: 31767144

Efficacy of dexamethasone treatment for patients with the acute respiratory distress syndrome caused by COVID-19: study protocol for a randomized controlled superiority trial. Villar J, Añón J, Ferrando C, Aguilar G, Muñoz T, Ferreres J, Ambrós A, Aldecoa C, Suárez-Sipmann F, Thorpe K, Jüni P, Slutsky A, DEXA-COVID19 Network. Trials. 2020 Aug 16;21(1):717. doi: 10.1186/s13063-020-04643-1. PMID: 32799933

Extubation strategies in neuro-intensive care unit patients and associations with outcomes: the ENIO multicentre international observational study. Cinotti R, Pelosi P, Schultz M, Aikaterini I, Alvarez P, Badenes Quiles R, Mc Credie V, Elbuzidi A, Elhadi M, Agustin Godoy D, Gurjar M, Haenggi M, Kaye C, Cesar Mijangos-Mendez J, Piagnerelli M, Piracchio R, Reza S, Stevens R, Yoshitoyo U, Asehnoune K, ENIO Study Grp. Annals of Translational Medicine. 2020 Apr;8(7):503. doi: 10.21037/atm.2020.03.160. PMID: 32395547

Global Survey of Outcomes of Neurocritical Care Patients: Analysis of the PRINCE Study Part 2. Venkatasubba Rao CP, Suarez JI, Martin RH, Bauza C, Georgiadis A, Calvillo E, Claude Hemphill J, Sung G, Oddo M, Silvio Taccone F, LeRoux PD, PRINCE Study Investigators. Neurocritical Care. 2020 Feb;32(1):88-103. doi: 10.1007/s12028-019-00835-z. PMID: 31486027

Glucose and Lactate Concentrations in Cerebrospinal Fluid After Traumatic Brain Injury. Lozano A, Franchi F, Seastres R, Oddo M, Lheureux O, Badenes Quiles R, Scolletta S, Vincent J, Creteur J, Taccone F. Journal of Neurosurgical Anesthesiology. 2020 Apr;32(2):162-169. doi: 10.1097/ANA.0000000000000582. PMID: 30893283

Health outcomes and costs in patients with osteoarthritis and chronic pain treated with opioids in Spain: the OPIOIDS real-world study. Sicras Mainar A, Tornero Tornero C, Vargas Negrin F, Lizarraga I, Rejas Gutierrez J. Therapeutic Advances in Musculoskeletal Disease. 2020 Sep 17;12:1759720X20942000. doi: 10.1177/1759720X20942000. PMID: 32994809

Hemodynamic Monitoring in Patients With Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis. Simonassi F, Ball L, Badenes Quiles R, Millone M, Citerio G, Zona G, Pelosi P, Robba C. Journal of Neurosurgical Anesthesiology. 2020 Jan 31. doi: 10.1097/ANA.0000000000000679. PMID: 32011413

Hyperosmolar therapy for acute brain injury: study protocol for an umbrella review of meta-analyses and an evidence mapping. Badenes Quiles R, Hutton B, Citerio G, Robba C, Aguilar Aguilar G, Alonso-Arroyo A, Taccone F, Tornero Tornero C, Catala Lopez F. BMJ Open. 2020 Feb 6;10(2):e033913. doi: 10.1136/bmjopen-2019-033913. PMID: 32034026

International consensus on the monitoring of cerebral oxygen tissue pressure in neurocritical patients. Dominguez-Roldan JM, Lubillo S, Videtta W, Antonio Llompart-Pou J, Badenes Quiles R, Marquez Rivas J, Ibanez J, Godoy D, Murillo-Cabezas F, Gomez-Abascal L, Paranhos J, Recalde R, Miguel Montes J, Grp Expertos Monitorizacion Pacientes. Neurocirugia. 2020;31(1):24-36. doi: 10.1016/j.neucir.2019.08.003. PMID: 31708419

Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: post-hoc analysis of LAS VEGAS study. Robba C, Hemmes S, Neto A, Bluth T, Canet J, Hiesmayr M, Hollmann M, Mills G, Melo M, Putensen C, Jaber S, Schmid W, Severgnini P, Wrigge H, Battaglini D, Ball L, de Abreu M, Schultz M, Pelosi P, FERS LAS VEGAS Investigators, Soro Domingo M, European Soc Anaesthesiology. BMC Anesthesiology. 2020 Apr 2;20(1):73. doi: 10.1186/s12871-020-00988-x. PMID: 32241266

Limb Ischemic Conditioning Induces Oxidative Stress Followed by a Correlated Increase of HIF-1alpha in Healthy Volunteers. Garcia De La Asuncion J, Perez Griera J, Moreno Sanchez T, Duca A, Garcia Del Olmo E, Belda Nacher F, Soro Domingo M. Annals of Vascular Surgery. 2020 Jan;62:412-419. doi: 10.1016/j.avsg.2019.06.033. PMID: 31449936

Lung injury is a predictor of cerebral hypoxia and mortality in traumatic brain injury. Robba C, Asgari S, Gupta A, Badenes Quiles R, Sekhon M, Bequiri E, Hutchinson P, Pelosi P, Gupta A. Frontiers in Neurology. 2020 Aug 7;11:771. doi: 10.3389/fneur.2020.00771. PMID: 32849225

Neurally adjusted ventilatory assist in acute respiratory failure: a randomized controlled trial. Kacmarek R, Villar J, Parrilla D, Alba F, Solano R, Liu S, Montiel R, Rico-Feijoo J, Vidal A, Ferrando C, Murcia I, Corpas R, Gonzalez-Higueras E, Sun Q, Pinedo C, Pestana D, Martinez D, Aldecoa C, Anon J, Soro Domingo M, Gonzalez-Martin J, Fernandez C, Fernandez R. Intensive Care Medicine. 2020 Dec;46(12):2327-2337. doi: 10.1007/s00134-020-06181-5. PMID: 32893313

Optimizing ceftolozane-tazobactam dosage during continuous renal replacement therapy: some nuances. Aguilar Aguilar G, Ferriols Lisart R, Martínez Castro S, Ezquer Garin C, Pastor Martinez E, Carbonell Lopez J, Alos Almiñana M, Navarro Ortega D. Critical Care. 2020 Jan 10;24(1):11. doi: 10.1186/s13054-019-2724-y. PMID: 31924240

Plasma Hyperosmolality Prolongs QTc Interval and Increases Risk for Atrial Fibrillation in Traumatic Brain Injury Patients. Dabrowski W, Siwicka-Gieroba D, Robba C, Badenes Quiles R, Bialy M, Iwaniuk P, Schlegel T, Jaroszynski A. Journal of Clinical Medicine. 2020 Apr 30;9(5):1293. doi: 10.3390/jcm9051293. PMID: 32365845

Prediction of Opioid-Induced Respiratory Depression on Inpatient Wards Using Continuous Capnography and Oximetry: An International Prospective, Observational Trial. PRediction of Opioid-induced respiratory Depression In patients monitored by capnoGraphY (PRODIGY) Group Collaborators. Anesthesia and Analgesia. 2020 Oct;131(4):1012-1024. doi: 10.1213/ANE.0000000000004788. PMID: 32304460

Sepsis at ICU admission does not decrease 30-day survival in very old patients: a post-hoc analysis of the VIP1 multinational cohort study. Ibarz M, Boumendil A, Haas L, Irazabal M, Flaatten H, de Lange D, Morandi A, Andersen F, Bertolini G, Cecconi M, Christensen S, Faraldi L, Fjolner J, Jung C, Marsh B, Moreno R, Oeyen S, Ohman C, Bollen Pinto B, Soliman I, Szczeklik W, Valentin A, Watson X, Zaferidis T, Guidet B, Artigas A, Aguilar Aguilar G, VIP1 study. Annals of Intensive Care. 2020 May 13;10(1):56. doi: 10.1186/s13613-020-00672-w. PMID: 32406016

The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database. Vincent J, Ferguson A, Pickkers P, Jakob S, Jaschinski U, Almekhlafi G, Leone M, Mokhtari M, Fontes L, Bauer P, Sakr Y, Aguilar Aguilar G, ICON Investigators. Critical Care. 2020 Apr 23;24(1):171. doi: 10.1186/s13054-020-02858-x. PMID: 32326981.

The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study. Guidet B, de Lange D, Boumendil A, Leaver S, Watson X, Boulanger C, Szczeklik W, Artigas A, Morandi A, Andersen F, Zafeiridis T, Jung C, Moreno R, Walther S, Oeyen S, Schefold J, Cecconi M, Marsh B, Joannidis M, Nalapko Y, Elhadi M, Fjolner J, Flaatten H, Aguilar Aguilar G, VIP2 Study Grp. Intensive Care Medicine. 2020 Jan;46(1):57-69. doi: 10.1007/s00134-019-05853-1. PMID: 31784798

Update of the treatment of nosocomial pneumonia in the ICU. Zaragoza R, Vidal-Cortes P, AGUILAR AGUILAR G, Borges M, Diaz E, Ferrer R, Maseda E, Nieto M, Nuvials F, Ramirez P, Rodriguez A, Soriano C, Veganzones J, Martin-Loeches I. Critical Care. 2020 Jun 29;24(1):383. doi: 10.1186/s13054-020-03091-2. PMID: 32600375

Worldwide Organization of Neurocritical Care: Results from the PRINCE Study Part 1. Suarez J, Martin R, Bauza C, Georgiadis A, Venkatasubba Rao C, Calvillo E, Hemphill J, Sung G, Oddo M, Taccone F, LeRoux P, Badenes Quiles R, PRINCE Study Investigators. Neurocritical Care. 2020 Feb;32(1):172-179. doi: 10.1007/s12028-019-00750-3. PMID: 31175567

Development of a quality indicator set to measure and improve quality of ICU care for patients with traumatic brain injury. Huijben JA, Wiegers EJA, de Keizer NF, Maas AIR, Menon D, Ercole A, Citerio G, Lecky F, Wilson L, Cnossen MC, Polinder S, Steyerberg EW, van der Jagt M, Lingsma HF; Delphi panel. Critical Care. 2019 Mar 22;23(1):95. doi: 10.1186/s13054-019-2377-x. PMID: 30902117

Glia to neuron ratio in the posterior aspect of the human spinal cord at thoracic segments relevant to spinal cord stimulation. Ruiz Sauri A, Orduña Valls J, Blasco-Serra A, Tornero Tornero C, Cedeno D, Bejarano-Quisoboni D, Valverde-Navarro A, Benyamin R, Vallejo R. Journal of Anatomy. 2019 Nov;235(5):997-1006. doi: 10.1111/joa.13061. PMID: 31347695

High-flow nasal cannula oxygenation reduces postoperative hypoxemia in morbidly obese patients: a randomized controlled trial. Ferrando C1,2, Puig J3, Serralta F4, Carrizo J4, Pozo N4, Arocas B4, Gutierrez A4, Villar J5,6,7, Belda FJ4, Soro M4.. Minerva Anestesiologica. 2019 Oct;85(10):1062-1070. doi: 10.23736/S0375-9393.19.13364-0. PMID: 30994312

Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial: study protocol for a multicentre international trial of cardiac output-guided fluid therapy with low-dose inotrope infusion compared with usual care in patients undergoing major elective gastrointestinal surgery. Edwards MR, Forbes G, MacDonald N, Berdunov V, Mihaylova B, Dias P, Thomson A, Grocott MP, Mythen MG, Gillies MA, Sander M, Phan TD, Evered L, Wijeysundera DN, McCluskey SA, Aldecoa C, Ripollés-Melchor J, Hofer CK, Abukhudair H, Szczeklik W, Grigoras I, Hajjar LA, Kahan BC, Pearse RM; OPTIMISE II investigators. BMJ Open. 2019 Jan 15;9(1):e023455. doi: 10.1136/bmjopen-2018-023455. PMID: 30647034

Optimizing ceftolozane-tazobactam dosage in critically ill patients during continuous venovenous hemodiafiltration. Aguilar G, Ferriols R, Martínez-Castro S, Ezquer C, Pastor E, Carbonell JA, Alós M, Navarro D. Critical Care. 2019 Apr 26;23(1):145. doi: 10.1186/s13054-019-2434-5. PMID: 31027499

Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study. Kirmeier E, Eriksson LI, Lewald H, Jonsson Fagerlund M, Hoeft A, Hollmann M, Meistelman C, Hunter JM, Ulm K, Blobner M; POPULAR Contributors. Lancet Respiratory Medicine. 2019 Feb;7(2):129-140. doi: 10.1016/S2213-2600(18)30294-7. PMID: 30224322

Preoperative predictive model for acute kidney injury after elective cardiac surgery: a prospective multicenter cohort study. Callejas R, Panadero A, Vives M, Duque P, Echarri G, Monedero P; Renal Dysfunction in Cardiac Surgery Spanish Group (GEDRCC2).Minerva Anestesiologica. 2019 Jan;85(1):34-44. doi: 10.23736/S0375-9393.18.12257-7. PMID: 29756690

Prospective observational cohort study on grading the severity of postoperative complications in global surgery research. International Surgical Outcomes Study (ISOS) group. British Journal of Surgery. 2019 Jan;106(2):e73-e80. doi: 10.1002/bjs.11025. PMID: 30620066

Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV). Carramiñana A, Ferrando C, Unzueta MC, Navarro R, Suárez-Sipmann F, Tusman G, Garutti I, Soro M, Pozo N, Librero J, Gallego L, Ramasco F, Rabanal JM, Rodriguez A, Sastre J, Martinez J, Coves S, García P, Aguirre-Puig P, Yepes J, Lluch A, López-Herrera D, Leal S, Vives M, Bellas S, Socorro T, Trespalacios R, Salazar CJ, Mugarra A, Cinnella G, Spadaro S, Futier E, Ferrer L, Cabrera M, Ribeiro H, Celestino C, Kucur E, Cervantes O, Morocho D, Delphy D, Ramos C, Villar J, Belda J; iPROVE-OLV Network. Journal of Cardiothoracic and Vascular Anesthesia. 2019 Sep;33(9):2492-2502. doi: 10.1053/j.jvca.2019.01.056. PMID: 30928294

The quest for the perfect Weaning Index. Ferrando C, Mellado R, Belda FJ. Minerva Anestesiologica. 2019 Apr;85(4):336-337. doi: 10.23736/S0375-9393.19.13593-6. PMID: 30871309

Variation in neurosurgical management of traumatic brain injury: a survey in 68 centers participating in the CENTER-TBI study (vol 161, pg 453, 2019). van Essen TA, den Boogert HF, Cnossen MC, de Ruiter GCW, Haitsma I, Polinder S, Steyerberg EW, Menon D, Maas AIR, Lingsma HF, Peul WC; CENTER-TBI Investigators and Participants. Acta Neurochirurgica. 2019 Mar;161(3):451-455. doi: 10.1007/s00701-019-03815-6. PMID: 30715604