Grupo de investigación en envejecimiento y ejercicio físico

Área de Metabolismo y Daño Orgánico

Medicina regenerativa en el envejecimiento

Identificación del entrenamiento físico como fármaco para tratar la fragilidad asociada a la edad

Probar que G6PD protege del daño oxidativo y mejora la vida útil en ratones

Estrés reductor: un nuevo concepto en la enfermedad de Alzheimer

Coordinador
Dr. José Viña Ribes
jose.vina@uv.es

INVESTIGADORES
R4 Senior

José Viña Ribes    

R3 Consolidado

Ana Lloret Alcañiz
Consolación García Lucerga
Eva Serna García

R2 Novel / Emergente

José Viña Almunia
Paloma Monllor Taltavull

R1 Predoctoral

Ángela García Correas

STAFF
Colaborador/a
Enfermero/a
Técnico/a
Apoyo

Cristina Amézcua García

Publicaciones
Impact of supplementation with vitamins B6, B12, and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: a systematic review. Olaso-Gonzalez G, Inzitari M, Bellelli G, Morandi A, Barcons N, Vina J. IUBMB Life. 2022 Jan;74(1):74-84. doi: 10.1002/iub.2507. PMID: 34058062

A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts. Gomez-Cabrero D, Walter S, Abugessaisa I, Minambres-Herraiz R, Palomares L, Butcher L, Erusalimsky J, Garcia-Garcia F, Carnicero J, Hardman T, Mischak H, Zurbig P, Hackl M, Grillari J, Fiorillo E, Cucca F, Cesari M, Carrie I, Colpo M, Bandinelli S, Feart C, Peres K, Dartigues J, Helmer C, Vina J, Olaso G, Garcia-Palmero I, Martinez J, Jansen-Durr P, Grune T, Weber D, Lippi G, Bonaguri C, Sinclair A, Tegner J, Rodriguez-Manas L. GeroScience. 2021 Jun;43(3):1317-1329. doi: 10.1007/s11357-021-00334-0. PMID: 33599920

Adolescent binge-ethanol accelerates cognitive impairment and beta-amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice. Carlos Ledesma J, Rodriguez-Arias M, Gavito A, Sanchez-Perez A, Viña Ribes J, Medina Vera D, Rodriguez De Fonseca F, Minarro J. Addiction Biology. 2021 Jan;26(1):e12883. doi: 10.1111/adb.12883. PMID: 32043730

Adult Neural Stem Cell Migration Is Impaired in a Mouse Model of Alzheimer’s Disease. Esteve D, Molina-Navarro MM, Giraldo E, Martínez-Varea N, Blanco-Gandia MC, Rodríguez-Arias M, García-Verdugo JM, Viña J, Lloret A. Molecular neurobiology. 2021 Dec 11. doi: 10.1007/s12035-021-02620-6. PMID: 34894324

Aerobic exercise during advance stage of uncontrolled arterial hypertension. Pagan LU, Gomes MJ, Damatto RL, Lima Aline RR, Cezar MDM, Damatto FC, Reyes DRA, Campos DHS, Caldonazo TMM, Polegato BF, Fernandes DC, Laurindo FR, Fernandes AAH, Lloret A, Cicogna AC, Okoshi MP, Okoshi K. Frontiers in Physiology. 2021 Jun 3;12:675778. doi: 10.3389/fphys.2021.675778. PMID: 34149455

Bcl-xL as a Modulator of Senescence and Aging. Mas-Bargues C, Borras C, Vina J. International Journal of Molecular Sciences. 2021 Feb 3;22(4):1527. doi: 10.3390/ijms22041527. PMID: 33546395

Diagnostic performance of muscle echo intensity and fractal dimension for the detection of frailty phenotype. Miron Mombiela R, Vucetic J, Monllor P, Cardenas-Herran JS, Taltavull de la Paz P, Borras C. Ultrasonic Imaging. 2021 Nov;43(6):337-352. doi: 10.1177/01617346211029656. PMID: 34238072

Electroencephalography as a non-invasive biomarker of alzheimer’s disease: a forgotten candidate to substitute CSF molecules?. Monllor P, Cervera-Ferri A, Lloret MA, Esteve D, Lopez B, Leon JL, Lloret A. International Journal of Molecular Sciences. 2021 Oct 8;22(19):10889. doi: 10.3390/ijms221910889. PMID: 34639229

Estrogen replacement therapy induces antioxidant and longevity-related genes in women after medically induced menopause. Borras C, Ferrando M, Ingles M, Gambini J, Lopez-Grueso R, Edo R, Mas-Bargues C, Pellicer A, Vina J. Oxidative Medicine and Cellular Longevity. 2021 Sep 9;2021:8101615. doi: 10.1155/2021/8101615. PMID: 34539974

Exercise training as a modulator of epigenetic events in prostate tumors. Dufresne S, Gueritat J, Wong CP, Isanejad A, Ho E, Serna E, Gomez-Cabrera MC, Rebillard A. Prostate Cancer and Prostatic Diseases. 2021 May 18. doi: 10.1038/s41391-021-00380-x. PMID: 34007020

Facial alveolar bone thickness and modifying factors of anterior maxillary teeth: a systematic review and meta-analysis of cone-beam computed tomography studies. Rojo-Sanchis J, Soto-Penaloza D, Penarrocha-Oltra D, Penarrocha-Diago M, Vina-Almunia J. BMC Oral Health. 2021 Mar 22;21(1):143. doi: 10.1186/s12903-021-01495-2. PMID: 33752651

Frailty assessment in a stable COPD cohort: is there a COPD-frail phenotype?. Naval E, Cruz Gonzalez M, Giraldos S, Calatayud J, Jornet M, Lluch I, Meseguer M, Ruiz Cubillan JJ, Vina J, Tarazona-Santabalbina FJ. COPD-Journal of Chronic Obstructive Pulmonary Disease. 2021 Sep 9;1-8. doi: 10.1080/15412555.2021.1975670. PMID: 34503389

Glucosamine supplementation improves physical performance in trained mice. De la Rosa A, Olaso-Gonzalez G, Garcia-Dominguez E, Mastaloudis A, Hester S, Wood S, Gomez-Cabrera M, Vina J. Medicine and Science in Sports and Exercise. 2021 Oct 27. doi: 10.1249/MSS.0000000000002821. PMID: 34711707

Glucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage. Arc-Chagnaud C, Salvador-Pascual A, Garcia-Dominguez E, Olaso-Gonzalez G, Correas A, Serna E, Brioche T, Chopard A, Fernandez-Marcos P, Serrano M, Serrano A, Munoz-Canoves P, Sebastia V, Vina J, Carmen Gomez-Cabrera M. Journal of Cachexia Sarcopenia and Muscle. 2021 Dec;12(6):1879-1896. doi: 10.1002/jcsm.12792. PMID: 34704386

Healthcare for older adults, where are we moving towards?. Tarazona-Santabalbina F, Gonzalez S, Navarro J, Vina J. International Journal of Environmental Research and Public Health. 2021 Jun 8;18(12):6219. doi: 10.3390/ijerph18126219. PMID: 34201289

Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers. Garcia-Gimenez J, Mena-Molla S, Tarazona-Santabalbina F, Vina J, Gomez-Cabrera M, Pallardo F. International Journal of Environmental Research and Public Health. 2021 Feb 15;18(4):1883. doi: 10.3390/ijerph18041883. PMID: 33672064

Integrating pheromonal and spatial information in the amygdalo-hippocampal network. Villafranca-Faus M, Esteban Vila-Martin M, Esteve D, Merino E, Teruel-Sanchis A, Cervera-Ferri A, Martinez-Ricos J, Lloret A, Lanuza E, Teruel-Marti V. Nature Communications. 2021 Sep 6;12(1):5286. doi: 10.1038/s41467-021-25442-5. PMID: 34489431

Is oxidative stress the link between cerebral small vessel disease, sleep disruption, and oligodendrocyte dysfunction in the onset of Alzheimer’s disease?. Lloret A, Esteve D, Lloret MA, Monllor P, Lopez B, Leon JL, Cervera-Ferri A. Frontiers in Physiology. 2021 Aug 25;12:708061. doi: 10.3389/fphys.2021.708061. PMID: 34512381

Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus. Borras C, Abdelaziz KM, Diaz A, Gambini J, Jove M, Lopez-Grueso R, Mas-Bargues C, Monleon D, Pamplona R, Vina J. Mechanisms of Ageing and Development. 2021 Dec;200:111596. doi: 10.1016/j.mad.2021.111596. PMID: 34774606

Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease. Mas-Bargues C, Escrivá C, Dromant M, Borrás C, Viña J. Archives of Biochemistry and Biophysics. 2021 Sep 30;709:108941. doi: 10.1016/j.abb.2021.108941. PMID: 34097903

Long-lived humans have a unique plasma sphingolipidome. Pradas I, Jove M, Huynh K, Ingles M, Borras C, Mota-Martorell N, Galo-Licona JD, Puig J, Vina J, Meikle PJ, Pamplona R. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2021 Dec 5;glab360. doi: 10.1093/gerona/glab360. PMID: 34871393

Moderate Red Wine Consumption Increases the Expression of Longevity-Associated Genes in Controlled Human Populations and Extends Lifespan in Drosophila melanogaster. Gambini J, Gimeno-Mallench L, Olaso-Gonzalez G, Mastaloudis A, Traber M, Monleon D, Borras C, Vina J. Antioxidants. 2021 Feb 16;10(2):301. doi: 10.3390/antiox10020301. PMID: 33669360

Multicomponent training prevents memory deficit related to amyloid-beta protein-induced neurotoxicity. Soares CB, Dare LR, Lima KR, Lopes LF, Santos A, Garcia Dos A, Schimidt HL, Carpes FP, Lloret A, Vina J, Mello-Carpes P. Journal of Alzheimer’s Disease. 2021;83(1):143-154. doi: 10.3233/JAD-210424. PMID: 34275902

Overexpression of glucose 6 phosphate dehydrogenase preserves mouse pancreatic beta cells function until late in life. De la Rosa A, Gomez-Cabrera M, Vinue A, Gonzalez-Navarro H, Sanchez-Andres J, Vina J. Free radical biology & medicine. 2021 Feb 20;164:149-153. doi: 10.1016/j.freeradbiomed.2020.12.439. PMID: 33418115

Redox-related biomarkers in physical exercise. Gomez-Cabrera C, Carretero A, Millan-Domingo F, Garcia-Dominguez E, Correas AG, Olaso-Gonzalez G, Vina J. Redox Biology. 2021 Jun;42:101956. doi: 10.1016/j.redox.2021.101956. PMID: 33811000

Serum Levels of Clusterin, PKR, and RAGE Correlate with Amyloid Burden in Alzheimer’s Disease. Monllor P, Giraldo E, Badia M, de la Asuncion J, Alonso M, Lloret A, Vina J. Journal of Alzheimer’s disease. 2021;80(3):1067-1077. doi: 10.3233/JAD-201443. PMID: 33646167

Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates. Duro-Castano A, Borras C, Herranz-Perez V, Blanco-Gandia M, Conejos-Sanchez I, Arminan A, Mas-Bargues C, Ingles M, Minarro J, Rodriguez-Arias M, Garcia-Verdugo J, Vina J, Vicent M. Science Advances. 2021 Mar 26;7(13):eabf9180. doi: 10.1126/sciadv.abf9180. PMID: 33771874

The oscillatory profile induced by the anxiogenic drug FG-7142 in the amygdala-hippocampal network is reversed by infralimbic deep brain stimulation: relevance for mood disorders. Vila-Merkle H, Gonzalez-Martinez A, Campos-Jimenez R, Martinez-Ricos J, Teruel-Marti V, Blasco-Serra A, Lloret A, Celada P, Cervera-Ferri A. Biomedicines. 2021 Jul 6;9(7):783. doi: 10.3390/biomedicines9070783. PMID: 34356846

A Novel Micronutrient Blend Mimics Calorie Restriction Transcriptomics in Multiple Tissues of Mice and Increases Lifespan and Mobility in C. elegans. Serna García E, Mastaloudis A, Martorell P, Wood S, Hester S, Bartlett M, Prolla T, Viña Ribes J. Nutrients. 2020 Feb 14;12(2):486. doi: 10.3390/nu12020486. PMID: 32075050

Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators. Serna E, Cespedes C, Vina J. International Journal of Molecular Sciences. 2020 Dec 31;22(1):374. doi: 10.3390/ijms22010374. PMID: 33396477

BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians. Borras Blasco C, Mas Bargues C, Roman-Dominguez A, Sanz Ros J, Gimeno Mallench L, Inglés De La Torre M, Gambini Buchon J, Viña Ribes J. International Journal of Molecular Sciences. 2020 Jan 9;21(2):418. doi: 10.3390/ijms21020418. PMID: 31936510

Centenarians: An excellent example of resilience for successful ageing. Borras Blasco C, Inglés De La Torre M, Mas Bargues C, Dromant M, Sanz Ros J, Roman-Dominguez A, Gimeno Mallench L, Gambini Buchon J, Viña Ribes J. Mechanisms of Ageing and Development. 2020 Mar;186:111199. doi: 10.1016/j.mad.2019.111199. PMID: 31899226

Early reductive stress and late onset overexpression of antioxidant enzymes in experimental myocardial infarction. Carretero Martínez A, Gomez Cabrera M, Rios Navarro C, Salvador Pascual A, Bodí Peris V, Viña Ribes J. Free Radical Research. 2020 Mar;54(2-3):173-184. doi: 10.1080/10715762.2020.1735632. PMID: 32103692

Evaluation of an Antioxidant and Anti-inflammatory Cocktail Against Human Hypoactivity-Induced Skeletal Muscle Deconditioning. Arc-Chagnaud C, Py G, Fovet T, Roumanille R, Demangel R, Pagano A, Delobel P, Blanc S, Jasmin B, Blottner D, Salanova M, Gomez Cabrera M, Viña Ribes J, Brioche T, Chopard A. Frontiers in Physiology. 2020 Feb 12;11:71. doi: 10.3389/fphys.2020.00071. PMID: 32116779

Extracellular vesicles and redox modulation in aging. Borras Blasco C, Mas Bargues C, Sanz Ros J, Román Domínguez M, Gimeno Mallench L, Inglés De La Torre M, Gambini Buchon J, Viña Ribes J. Free Radical Biology and Medicine. 2020 Mar;149:44-50. doi: 10.1016/j.freeradbiomed.2019.11.032. PMID: 31783096

Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1alpha Activation. Mas Bargues C, Sanz Ros J, Román Domínguez M, Gimeno Mallench L, Inglés De La Torre M, Viña Ribes J, Borras Blasco C. Biomolecules. 2020 Jun 25;10(6):957. doi: 10.3390/biom10060957. PMID: 32630449

Garcinoic acid prevents beta-amyloid (Abeta) deposition in the mouse brain. Marinelli R, Torquato P, Bartolini D, Mas Bargues C, Bellezza G, Gioiello A, Borras Blasco C, De Luca A, Fallarino F, Sebastiani B, Mani S, Sidoni A, Viña Ribes J, Leri M, Bucciantini M, Nardiello P, Casamenti F, Galli F. Journal of biological chemistry. 2020 Aug 14;295(33):11866-11876. doi: 10.1074/jbc.RA120.013303. PMID: 32616652

Hippocampal oscillatory dynamics and sleep atonia are altered in an animal model of fibromyalgia: implications in the search for biomarkers. Blasco-Serra A, Alfosea-Cuadrado G, Cervera-Ferri A, Gonzalez-Soler E, Lloret Alcañiz A, Martinez-Ricos J, Teruel-Marti V, Valverde-Navarro A. Journal of Comparative Neurology. 2020 Jun;528(8):1367-1391. doi: 10.1002/cne.24829. PMID: 31785155

Increased basal antioxidant levels in RCAN1 – deficient mice lowers oxidative injury after acute paraquat insult. Lloret Alcañiz A, Monllor Taltavull P, Fuchsberger T, Giraldo Reboloso E, Perluigi M, Viña Ribes J. Free Radical Research. 2020 Jun;54(6):442-454. doi: 10.1080/10715762.2020.1798002. PMID:32686528

Influence of occlusal loading on peri-implant inflammatory cytokines in crevicular fluid: a prospective longitudinal study. Viña Almunia J, Pellicer-Chover H, Garcia-Mira B, Romero-Millan J, Penarrocha-Oltra D, Penarrocha-Diago M. International Journal Of Implant Dentistry. 2020 Oct 28;6(1):71. doi: 10.1186/s40729-020-00262-2. PMID: 33111201

Influence of the use of autogenous bone particles to close the access window after maxillary sinus floor augmentation: an experimental study in rabbits. Favero G, Vina-Almunia J, Carda C, de Llano J, Garcia-Mira B, Soto-Penaloza D, Penarrocha-Diago M, Botticelli D. International Journal of Implant Dentistry. 2020 Mar 4;6(1):9. doi: 10.1186/s40729-020-0206-2. PMID: 32128632

Is Sleep Disruption a Cause or Consequence of Alzheimer’s Disease? Reviewing Its Possible Role as a Biomarker. Lloret M, Cervera-Ferri A, Nepomuceno M, Monllor P, Esteve D, Lloret Alcañiz A. International Journal of Molecular Sciences. 2020 Feb 10;21(3):1168. doi: 10.3390/ijms21031168. PMID: 32050587

Methionine transsulfuration pathway is upregulated in long-lived humans. Mota-Martorell N, Mariona J, Consuelo B, Rebeca B, Elia O, Joaquim S, Rosanna C, Irene P, Galo-Licona J, Josep P, Jose V, Reinald P. Free Radical Biology & Medicine. 2020 Nov 30;162:38-52. doi: 10.1016/j.freeradbiomed.2020.11.026. PMID: 33271279

Modulating Oxidant Levels to Promote Healthy Aging. Viña Ribes J, Olaso González G, Arc-Chagnaud C, De La Rosa González A, Gomez Cabrera M. Antioxidants & Redox Signaling. 2020 Sep 10;33(8):570-579. doi: 10.1089/ars.2020.8036. PMID: 32008355

Multicomponent Exercise Training Combined with Nutritional Counselling Improves Physical Function, Biochemical and Anthropometric Profiles in Obese Children: A Pilot Study. Cordellat Marzal A, Padilla Lopez B, Grattarola P, Garcia Lucerga C, Crehuá Gaudiza E, Nuñez Gomez F, Martinez Costa C, Blasco Lafarga M. Nutrients. 2020 Sep 6;12(9):2723. doi: 10.3390/nu12092723. PMID: 32899955

Ovarian transcriptomic analysis reveals differential expression genes associated with cell death process after selection for ovulation rate in rabbits. Serna-Garcia M, Peiro R, Serna E, Santacreu MA. Animals. 2020 Oct 20;10(10):1924. doi: 10.3390/ani10101924. PMID: 33092110

Oxidative Stress and Mitochondrial Damage in Neurodegenerative Diseases: From Molecular Mechanisms to Targeted Therapies. Cenini G, Lloret Alcañiz A, Cascella R. Oxidative Medicine and Cellular Longevity. 2020 May 4;2020:1270256. doi: 10.1155/2020/1270256. PMID: 32454930

Physical exercise in the prevention and treatment of Alzheimer’s disease. De La Rosa González A, Olaso Gonzalez G, Arc-Chagnaud C, Millán F, Salvador Pascual A, Garcia Lucerga C, Blasco Lafarga M, Garcia Dominguez E, Carretero Martínez A, Correas A, Viña Ribes J, Gomez Cabrera M. Journal of Sport and Health Science. 2020 Sep;9(5):394-404. doi: 10.1016/j.jshs.2020.01.004. PMID: 32780691

Redox modulation of muscle mass and function. Gomez Cabrera M, Arc-Chagnaud C, Salvador Pascual A, Brioche T, Chopard A, Olaso González G, Viña Ribes J. Redox Biology. 2020 Aug;35:101531. doi: 10.1016/j.redox.2020.101531. PMID: 32371010

Relationship between Diet, Microbiota, and Healthy Aging. Sanchez-Morate E, Gimeno Mallench L, Stromsnes K, Sanz Ros J, Roman-Dominguez A, Parejo-Pedrajas S, Inglés De La Torre M, Olaso González G, Gambini Buchon J, Mas Bargues C. Biomedicines. 2020 Aug 14;8(8):287. doi: 10.3390/biomedicines8080287. PMID: 32823858

Screening for and Managing the Person with Frailty in Primary Care: ICFSR Consensus Guidelines. Ruiz J, Dent E, Morley J, Merchant R, Beilby J, Beard J, Tripathy C, Sorin M, Andrieu S, Aprahamian I, Arai H, Aubertin-Leheudre M, Bauer J, Cesari M, Chen L, Cruz-Jentoft A, De Souto Barreto P, Dong B, Ferrucci L, Fielding R, Flicker L, Lundy J, Reginster J, Rodriguez-Manas L, Rolland Y, Sanford A, Sinclair A, Viña Ribes J, Waters D, Won C, Woo J, Vellas B. Journal of Nutrition Health & Aging. 2020;24(9):920-927. doi: 10.1007/s12603-020-1492-3. PMID: 33155616

Special issue: Exercise redox biology from health to performance. Gomez Cabrera M, Viña Ribes J, Olaso González G. Redox Biology. 2020 Aug;35:101584. doi: 10.1016/j.redox.2020.101584. PMID:32448750

Special issue: Redox Signalling in Health and Disease. Borras Blasco C, Viña Ribes J. Free Radical Biology And Medicine. 2020 Mar;149:1. doi: 10.1016/j.freeradbiomed.2020.02.009. PMID: 32061736

The Status of EGFR Modulates the Effect of miRNA-200c on ZEB1 Expression and Cell Migration in Glioblastoma Cells. Munoz-Hidalgo L, San-Miguel T, Megias J, Serna E, Calabuig-Farinas S, Monleon D, Gil-Benso R, Cerda-Nicolas M, Lopez-Gines C. International Journal of Molecular Sciences. 2020 Dec 31;22(1):368. doi: 10.3390/ijms22010368. PMID: 33396457

Transcriptomic identification of miR-205 target genes potentially involved in metastasis and survival of cutaneous malignant melanoma. Sanchez Sendra B, Serna García E, Navarro Cerveró L, González Muñoz J, Portero Trigo J, Ramos Jarero A, Murgui Faubel A, Monteagudo Castro C. Scientific Reports. 2020 Mar 16;10(1):4771. doi: 10.1038/s41598-020-61637-4. PMID: 32179834

Proyectos
Referencia: AC20/00026
Título: Combining vitamin E-functionalized CHOcolate with physical exercise to reduce the risK of protein energy malnutrition in pre-dementia AGEd people. ERA-HDHL Call for Joint Transnational Research Proposals on Development of targeted nutrition for prevention of undernutrition for older adults (PREVNUT)
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: José Viña Ribes
Duración: 2021 – 2023
Presupuesto: 169.098 €

Referencia: PROMETEO/2019/097
Título: Diferencias de fragilidad entre generos: Evaluación de biomarcadores y estrategias de intervención
Entidad Financiadora: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Investigador principal: José Viña Ribes
Duración: 2020 – 2023
Presupuesto: 189.391 €

Referencia: PID2019-110906RB-100
Título: Nuevas intervenciones terapéuticas multidominio para retrasar la fragilidad y la discapacidad. Identificación de mecanismos moleculares con relevancia traslacional (Mitofrail)
Entidad Financiadora: Ministerio de Economía y Competitividad
Investigador principal: José Viña Ribes, Mª Carmen Gómez Cabrera
Duración: 2020 – 2023
Presupuesto: 270.000 €

Referencia: 825546-DIABFRAIL-LATAM-
Título: Scaling-up of and evidence-based intervention programme in older people with Diabetes and Frailty in LatinAmerica
Entidad Financiadora: European Commission
Investigador principal: José Viña Ribes
Duración: 2019 – 2024
Presupuesto: 273.720 €

Referencia: POCTEP 0348_CIE_6_E
Título: Estudio de la fragilidad cognitiva y su transición a la demencia mediante un conjunto de biomarcadores en sangre periférica. Intervención con genisteína
Entidad Financiadora: Fundación General del Consejo Superior de Investigaciones Científicas (FGCSIC)
Investigador principal: José Viña Ribes
Duración: 2018 – 2019
Presupuesto: 39.940 €

Referencia: CB16/10/00435
Título: CIBER de Fragilidad y Envejecimiento (CIBERFES)
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: José Viña Ribes
Duración: 2017 –
Presupuesto:

Referencia: ADVANTAGE
Título: Managing Frailty. A comprehensive approach to promote a disability-free advanced age in Europe: the ADVANTAGE initiative
Entidad Financiadora: European Commission (3rd Health Program)
Investigador principal: Josep Redón i Mas, José Viña Ribes
Duración: 2016 – 2019
Presupuesto: 130005

Referencia: PIE15/00013
Título: A multidisciplinary Project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction
Entidad Financiadora: Instituto de Salud Carlos III – Cofinanciado FEDER
Investigador principal: Vicente Bodí Peris
Duración: 2016 – 2019
Presupuesto: 589.050 €

Referencia: SAF2016-75508-R
Título: Envejecimiento cerebral: protección contra el daño asociado al mismo y su aplicación a la enfermedad de Alzheimer
Entidad Financiadora: Ministerio de Economía y Competitividad
Investigador principal: José Viña Ribes
Duración: 2016 – 2019
Presupuesto: 169.400 €

+ Información
Screening for and Managing the Person with Frailty in Primary Care: ICFSR Consensus Guidelines. Ruiz J, Dent E, Morley J, Merchant R, Beilby J, Beard J, Tripathy C, Sorin M, Andrieu S, Aprahamian I, Arai H, Aubertin-Leheudre M, Bauer J, Cesari M, Chen L, Cruz-Jentoft A, De Souto Barreto P, Dong B, Ferrucci L, Fielding R, Flicker L, Lundy J, Reginster J, Rodriguez-Manas L, Rolland Y, Sanford A, Sinclair A, Viña Ribes J, Waters D, Won C, Woo J, Vellas B. Journal of Nutrition Health & Aging. 2020;24(9):920-927. doi: 10.1007/s12603-020-1492-3. PMID: 33155616

Título: Influencia del procesamiento de la leche humana donada sobre la microbiota intestinal, la expresión genómica y el equilibrio oxidativo en recién nacidos pretérmino menores de 32 semanas de edad gestacional
Doctorando: Parra Llorca, Anna
Director: Vento, Máximo; Collado Amores, María Carmen; Serna García, Eva
Fecha: 23/02/2021
Universidad: Universitat de València

Título: Análisis de la anchura de la cortical vestibular en dientes anteriores maxilares y en la planificación virtual de implantes mediante tomografías computarizadas de hazcónico
Doctorando: Rojo Sanchis, Julio
Director: Peñarrocha Oltra, David; Viña Almunia, Jose
Fecha: 30/04/2021
Universidad: Universitat de València

Título: Efecto de la ingesta de glutamato monosódico en la fisiopatología de la enfermedad de alzheimer
Doctorando: Yuste Pérez, Raquel
Director: Fuchsberger, Tanja; Viña Ribes, José; Lloret Alcañiz, Ana
Fecha: 22/07/2020
Universidad: Universitat de València

Título: Efecto de la activación del receptor PPARy/RxR como posible tratamiento de la enfermedad de Alzheimer. Papel de la genisteína
Doctorando: Muñoz Cebriá, José Enrique
Director: Viña, José; Borrás, Consuelo; Gambini, Juan
Fecha: 01/07/2020
Universidad: Universitat de València

Título: Impacto del ejercicio físico a largo plazo en la neuroprotección de sujetos de mediana edad: estudio de los mecanismos moleculares involucrados
Doctorando: De La Rosa González, Adrián
Director: Gómez Cabrera, M. Carmen; Sanfeliú Pujol, Coral; Viña Ribes, José
Fecha: 05/06/2020
Universidad: Universitat de València

Título: Regulation of antioxidant defenses in the prevention of skeletal muscle deconditioning
Doctorando: Arc-Chagnaud, Coralie
Director: Viña Ribes, José; Gómez-Cabrera, Carmen; Chopard, Angèle; Brioche, Thomas
Fecha: 22/11/2019
Universidad: Universitat de València

Título: Effect of two distinct implant macro-designs on the osseointegration of bicatortically installed implants in two topographic sites. A histomorphometric study in rabbit tibiae
Doctorando: Soto Peñaloza, David Reynaldo
Director: Peñarrocha Oltra, David; Viña Almunia, Jose; Martín De Llano, José Javier
Fecha: 15/11/2019
Universidad: Universitat de València

Título: El sedentarismo en los adultos mayores del entorno rural: estrategias de entrenamiento concentrado versus distribuido
Doctorando: Monteagudo Chiner, Pablo
Director: Blasco Lafarga, Cristina; Gómez Cabrera, M. Carmen; Pesce, Caterina
Fecha: 26/07/2019
Universidad: Universitat de València

Título: Moderate overexpression of glucose-6-phosphate dehydrogenase improves healthspan in mice. Implications in skeletal muscle regeneration
Doctorando: Salvador Pascual, Andrea
Director: Viña Ribes, José; Gomez Cabrera, M. Carmen
Fecha: 15/07/2019
Universidad: Universitat de València

Título: Entrenamiento respiratorio: cambios en la presión inspiratoria máxima y relación con la funcionalidad del adulto mayor sano
Doctorando: Roldán Aliaga, Ainoa
Director: Blasco Lafarga, Cristina; Blasco Lafarga, Nieves M; Gómez Cabrera, M. Carmen
Fecha: 20/05/2019
Universidad: Universitat de València

Título: Development of an ultrasound-based muscle texture analysis as a potential imaging biomarker for frailty phenotype
Doctorando: Mirón Mombiela, Rebeca
Director: Borrás Blasco, Consuelo; Forner Giner, Juana
Fecha: 28/01/2019
Universidad: Universitat de València